何艳,女,1988年1月出生,博士,2009年毕业于betway官方app 化学化工学院并获得理学学士学位;2009-2012年在betway官方app 化学化工学院攻读有机化学硕士学位,在导师范学森教授的指导下从事有机合成方法学的研究,2012年7月获得理学硕士学位;2012-2015年在betway官方app 环境学院攻读环境科学绿色合成方向的博士学位,在导师范学森教授的指导下主要从事基于官能团化联烯多样反应性能的绿色合成方法学研究,2015年12月获得工学博士学位。2015年12月进入betway官方app 环境学院工作。主持国家自然科学基金项目一项,河南省科技攻关计划项目一项,参与国家自然科学基金项目三项。在Green Chem., Chem. Comm., Org. Lett., J. Org. Chem., Chem. Asian J.,等SCI期刊发表论文20余篇。
绿色化学;有机合成化学;核苷衍生物的合成及性能
1. 城市污水生化处理出水中有机物对循环冷却水系统中矿物结垢、微生物结垢和金属腐蚀过程的作用及机理,国家自然科学基金,23万,主持。
2. 城市污水生化处理出水中有机物对冷却水系统结垢和腐蚀的影响,河南省博士后一等资助,10万,主持。
3. 选择性同步去除二级出水中硝酸盐/磷酸盐复合功能树脂制备及机理,河南省教育厅重点研究项目,3万,主持。
4. 3D多孔Cu/Pd双金属电极制备及城市污水电催化深度脱硝研究,betway官方app 青年科学基金项目,6万,主持。
代表性论文:
1. Fang Wang, Yan He*, Miaomiao Tian, Xinying Zhang, Xuesen Fan*. Synthesis of α-formylated N-heterocycles and their 1,1-diacetates through the cascade reactions of inactivated cyclic amines featured with an oxidative ring contraction. Org. Lett., 2018, 20, 864-867.
2. Yan He*, Fang Wang, Xinying Zhang, Xuesen Fan*. C(sp3)−H dehydrogenation and C(sp2)−H alkoxycarbonylation of inactivated cyclic amines towards functionalized N-heterocycles. Chem. Commun., 2017, 53, 4002-4005.
3. Yan He, Ningning Zhao, Liqi Qiu, Xinying Zhang*, Xuesen Fan*. Regio- and chemoselective mono- and bisnitration of 8-aminoquinoline amides with Fe(NO3)3·9H2O as promoter and nitro source. Org. Lett., 2016, 18, 6054-6057.
4.Xuesen Fan*, Yan He, Xinying Zhang, Jianji Wang. Sustainable and selective synthesis of 3,4-dihydro quinolizin-2-one and quinolizin-2-one derivatives via the reactions of penta-3,4-dien-2-ones. Green Chemistry, 2014, 16, 1393-1398.
5.Yan He, Xinying Zhang*, Liangyan Cui, Jianji Wang, Xuesen Fan*. Catalyst-free synthesis of diversely substituted 6H-benzo[c]chromenes and 6H-benzo[c]chromen-
6-ones in aqueous media under MWI. Green Chemistry, 2012, 14, 3429-3435.
6. Xuesen Fan*, Yan He, Liangyan Cui, Xinying Zhang, Jianji Wang. Tandem reaction of 1,2-allenic ketone with α-halo ketone or α-halo ester in water: an efficient and sustainable synthesis of 1,3,4'-tricarbonyl compounds. Green Chemistry, 2011, 13, 3218-3223.
7.Yan He, Xinying Zhang*, and Xuesen Fan*.Synthesis of diversely substituted 2-(furan-3-yl)acetates from allenols through cascade carbonylations. Chemical Communications, 2015, 51,16263-16266.
8.Yan He, Xinying Zhang,* and Xuesen Fan*.One-pot cascade reactions of 1-arylpenta- 3,4-dien-2-ones leading to 2-arylphenols and dibenzopyroanones. Chemical Communications, 2014, 50, 14968-14970.
9.Yan He, Xinying Zhang and Xuesen Fan*.Synthesis of naphthalene amino esters and arylnaphthalene lactone lignans through tandem reactions of 2-alkynylbenzonitriles. Chemical Communications, 2014, 50, 5641-5643.
10.Miaomiao Tian, Yan He, Xinying Zhang,* and Xuesen Fan*,Synthesis of Pyrazolo [5,1‑a]isoindoles and Pyrazolo[5,1‑a]isoindole-3-carboxamides through One-Pot Cascade Reactions of 1-(2-Bromophenyl)buta-2,3-dien-1-ones with Isocyanide and Hydrazine or Acetohydrazide. Journal of Organic Chemistry, 2015, 80, 7447-7455.
11.Yan He, Shenghai Guo, Xinying Zhang, and Xuesen Fan*.Zinc-mediated one-pot tandem reaction of nitriles with propargyl bromides: an easy access to 3-alkynylpyri dines and their applications. Journal of Organic Chemistry, 2014, 79, 10611.
12.Yan He, Xinying Zhang, Nana Shen, Xuesen Fan*. Tunable synthesis of 3-acyl-2- naphthols and 3-substituted isocoumarins via Jones reagent promoted cascade reacti ons of 2-(4-hydroxy-but-1-ynyl) benzaldehydes. Journal of Organic Chemistry, 2013, 78, 10178-10191.
13.Yan He, Xinying Zhang*, Liangyan Cui, Xuesen Fan*. Iodine-initiated domino reaction of hepta-1,2- dien-6-yn-4-ols and brønsted acid promoted cyclization of hepta-1,2,6-trien-4-ols leading to functionalized benzenes. Chemistry-An Asian Journal, 2013, 8, 717-722.
14.Yan He, Miaomiao Tian, Xinying Zhang, and Xuesen Fan*,Synthesis of 4-Oxo-
but-2-enals through tBuONO and TEMPO-Promoted Cascade Reactions of Homo
allylic Alcohols,Asian Journal of Organic Chemistry, 2016, DOI: 10.1002/ajoc.201600312
15.Yan He, Xinying Zhang, and Xuesen Fan*,Synthesis of Aminonaphthopyranones and Aminonaphthochromenones by Blaise-Reaction-Initiated Cascade Procedures,Asian Journal of Organic Chemistry, 2014, 3, 1284 – 1291。
16.Xuesen Fan*, Yan He, Liangyan Cui, Shenghai Guo, Jianji Wang, Xinying Zhang*. Tandem reactions leading to benzo[c]chromen-6-ones and 3-substituted isocoumarins. European Journal of Organic Chemistry, 2012 (4), 673-677.
17.Yan He, Nana Shen, Xuesen Fan*, Xinying Zhang. Synthesis of β-fluoroenones and their reductive rearrangement in aqueous media. Tetrahedron, 2013, 69, 8818-8823.
18.Xuesen Fan*, Yan He, Xinying Zhang, Shenghai Guo. Synthesis of heteroaryl ketones via tandem reaction of 1,1-dibromoethenes. Tetrahedron, 2011, 67, 6369-6374.
19.Yan He, Shenghai Guo, Xinying Zhang,* Chenhao Guo, and Xuesen Fan*. Synthesis of Dibenzo[b,d]furans through One-pot Cascade Reactions of 1-Arylpenta-3,4-dien-2- ones with Activated Ketones. Tetrahedron Letters, 2015, 56, 1513-1516.
20.Yan He, Shenghai Guo, Xuesen Fan*, Chenhao Guo, Xinying Zhang*.One-pot synthesis of 12H-benzo[b]xanthen-12-ones and naphtha[2,3-b]furans from non-naphthalene substrates. Tetrahedron Letters. 2014, 55, 4747–4752.
21.Xuesen Fan*, Yan He, Yangyang Wang, Zaikun Xue, Xinying Zhang, Jianji Wang. A novel and practical synthesis of 2-benzoyl benzothiazoles and 2-benzylbenzothia zoles. Tetrahedron Letters, 2011, 52, 899-902.
22.Xuesen Fan*, Yan He, Shenghai Guo, Xinying Zhang. RuCl3•3H2O catalyzed tandem reaction of alkynylbromides with 2-aminothiophenols in water: a convenient synthesis of 2-benzoylbenzothiazoles. Australian Journal of Chemistry, 2011, 64, 1568-1573.
23.Yan He, Xinying Zhang, Nana Shen, Xuesen Fan*. Synthesis of α-fluoroketones and α-fluoroenones in aqueous media. Journal of Fluorine Chemistry, 2013, 156, 9-14.
专利成果:
(1) 范学森,张新迎,李晓严,王洋洋,徐海云,郭胜海,何艳,具有抗HIV活性的5-取代嘧啶核苷-噻唑啉酮杂化体及其制备方法,2013.8.14,中国,ZL201210026427.X。
(2) 范学森,张新迎,何艳,郭胜海,田苗苗,一种吡唑并[5,1-a]异吲哚类化合物的合成方法,2015.9.23,中国,CN201510345540.8。
(3) 范学森,何艳,张新迎,郭胜海,田苗苗,一种吡唑并[5,1-a]异吲哚-3-甲酰胺类化合物的合成方法,2015.11.11,中国,CN201510345086.6。
(4) 范学森,张新迎,何艳,郭胜海,王园园,一种3-炔基吡啶类化合物的合成方法,2015.1.28,中国,CN201410515647.8。
(5) 张新迎,范学森,郭胜海,蒋盼盼,沈娜娜,何艳,李彬,具有抗寄生虫活性的核苷-苯基丙烯酮杂化体及其制备方法和应用,2015.4.8,中国,CN201410197474.X。
(6) 范学森,张新迎,冯东,王国利,王霞,郭胜海,王洋洋,何艳,贾雪菲,5-位缺电子烯基取代嘧啶碳环核苷及制备方法,2013.8.14,中国,CN201210026439.2。
(7) 张新迎,范学森,郭胜海,何艳,贾雪菲,崔良艳,方亮亮,5-位氢化苯并吡喃基取代嘧啶碳环核苷及制备方法,2013.8.14,中国,CN201210026464.0。
(8) 范学森,张新迎,冯东,王国利,曲莹莹,王洋洋,郭胜海,何艳,贾雪菲,5-甲酰基嘧啶碳环核苷及制备方法,2012.7.25,中国,CN201110463012.4。
(9) 范学森,张建瑞,张新迎,何艳,郭胜海,一种合成5-((E)-2-溴乙烯基)-2′-脱氧尿嘧啶核苷(溴呋啶)的方法,2012.5.2,中国,CN201110359183.2。