陈长坡个人简介

博士，教授，博士生导师，betway官方app 特聘教授 河南省高等学校化工与制药专业教学指导委员会副主任委员 河南省化工学会第一届教育工作委员会副主任委员 中国老年骨科学会基础学组专家委员会委员

教育经历：

1999/9-2002/7，北京大学，药物化学，博士，导师：张礼和院士

1988/9-1991/4，北京理工大学，应用化学，工学硕士，导师：陈恬生教授

1984/9-1988/7，河南大学，化学，学士

工作经历：

2014/6-至今，betway官方app ，化学化工学院，特聘教授，教授

2005/12-2014/5 (美国)托马斯杰弗逊大学，医学院，助理研究员，研究员

2003/2-2005/12 (美国)爱荷华大学，药学院，博士后

1995/11-1999/8化学工业部、国家石化局高级工程师，

1991/4-1995/11北京市发酵工业研究所，工程师

主讲课程：

《药物设计学》《生物缀合物化学》

研究领域与兴趣：

1.小分子肿瘤免疫治疗药物的设计合成与活性

2.人工离子通道的设计合成与功能表征

主持或参加科研项目：

1.NSF 21977025国家自然科学基金面上项目 含三氮唑模块的环二核苷酸类似物的设计合成与免疫活性研究，2020.1-2023.12, 66万元,主持

2.NSF U1604285国家自然科学基金委-河南省联合基金(重点项目) 2′,3′-环鸟苷腺苷酸类似物的设计、合成与构效关系研究，2017.1-2020.12, 215万元，第一参与人

3.NSF 21605041国家自然科学基金青年基金靶向干扰素刺激因子的免疫分子机制、虚拟筛选及生物活性研究，2017.1-2019.12 30万元，第一参与人。

代表性论文：

1. Pengyang Xin,*Lingyu Zhao, Linlin Mao, Linqi Xu, Shuaimin Hou, Huiyuan Kong,Haodong Fang, Haofeng Zhu, Tao Jiang,Chang-Po Chen*,Effect of ChargeStatuson theIon Transport andAntimicrobialActivityofSynthetic Channels.Chem. Commun.,2020,56, 13796-13799.

2. Shengrui Xu, Qingqing Liu, Cuicui Wang, Li Xiao, Suling Feng*, Ning Li,Chang-Po Chen*,Three-demensional prmpon -like Au/ZnO porous microspheres as solid phase microextraction coating for determination of volatile fatty acids from foot odor.Talanta, 2020, 209, 120519.

3. Yanwei Chi, Zhiying Wang, Jie Wang, Wenpei Dong, Pengyang Xin, Jingjing Bi, Tao Jiang*,Chang-Po Chen*, Dimeric camptothecin-loaded mPEG-PCL nanoparticles with high drug loading and reduction-responsive drug release.Coloid Polym. Sci., 2020, 298, 51–58.

4. 陈长坡*，李宁，徐生瑞，胡宗杰，健康人体足部挥发性物质形成及分析研究进展。betway官方app 学报（自然科学版），2019，47（5），57-64.

5. Jingjing Guo*，Jie Wang, Jingrong Fan, Yan Zhang, Wenpei Dong, andChangPo Chen*,Distinct Dynamical and Conformational Features of Human STING in Response to 2'3'-cGAMP and c-di-GMP.ChemBioChem,2019, 20(14), 1838-1847.

6. Tao Jiang, Xin Wang, Ge Wang, Yafu Wang, Kui Wang, Xiaopeng Xuan,Changpo Chen,*Kai Jiang, Hua Zhang,* Light-activated “cycle reversible ICT” fluorescent probe: Monitoring of pHi trace-change induced by UV in programmed cell death.Chem. Comm.,2019, 55, 5279-5282.

7. Pengyang Xin*, Huiyuan Kong, Yonghui Sun, Lingyu Zhao, Haodong Fang, ,Haofeng Zhu, Tao Jiang, Jingjing Guo, Qian Zhang, Wenpei Dong,Chang-Po Chen*Artificial K⁺Channels Formed by Pillararene-Cyclodextrin Hybrid Molecules: , Tuning Cation Selectivity and Generating Membrane Potential.Angew. Chem. Int. Edit. 2019, 58(9): 2779-2784.

8. Pardeep Kumar, Suhil K. Ttripathi,Chang-Po Chen,Eric Wickstrom, Mathew L. Thakur*. Evaluating Ga-68 peptide conjugates for targeting VPAC receptors: stability and pharmacokinetics.Mol. Imaging Biol.2019,21, 130-39.

9. Lingjun Li*, Xiaofang Xing, Chi Zhang, Anlian Zhu, Xincui Fan,Chang-Po Chen, Guisheng Zhang*. Novel synthesis of 5-iodo-1,2,3-triazoles using an aqueous iodination system under air.Tetrahedron Lett.2018, 59, 3563-3566.

10. Pengyang Xin,* Yonghui Sun, Huiyuan Kong, Yaodong Wang, Si Tan, Jingjing Guo, Tao Jiang, Wenpei Dong, *Chang-Po Chen*A unimolecular channel fromed by dual helical peptide modified pillar[5]arene: correlating transmembrane transport properties with antimicrobial activity and haemolytic toxicityChem. Comm.2017, 53, 11492-11495

11. Lingling Li, Luyao Liu,Chang-Po Chen*, Fengling Cu*, Green synthesis of nitrogen-doped carbon dots from ginkgo fruits and the application in cell imaging.Inorg. Chem. Comm.2017, 86, 227-231.

12. Chang-Po Chen, Rui-Yan Jing, and Eric Wickstrom*.Covalent attachment of daptomycin to Ti6Al4V alloy surfaces by a thioether linkage to inhibit colonization byStaphylococcus aureus.Acs Omega2017, 2(4), 1645-1652.

13. Pengyang Xin,* Si Tan, Yonghui Sun, Qiaojv Ren,Wenpei Dong, Jingjing Guo, Tao Jiang andChang-Po Chen*One-pot formation of hydrazide macrocycles with modified cavities: an example of pH-sensitive unimolecular cation channels.Chem. Comm.2017, 52, 5322-5325.

14. Pengyang Xin,* Si Tan, Yaodong Wang, Yonghui Sun, Yan Wang, Yuqing Xu andChang-Po Chen*Functionalized hydrazide macrocycle ion channels showing pH-sensitive ion selectivities.Chem. Comm.2017, 53, 625-628.

15. Lingjun Li* Shengqiang Ding, Yanping Yang, Anlian Zhu, Xincui Fan, Mengchao Cui*,Changpo Chen, Guisheng Zhang* Multicomponent Aqueous Synthesis of Iodo-1,2,3-triazoles:Single-Step Models for Dual Modification of Free Peptide and Radioactive Iodo Labeling.Chem. Eur. J.2017, 23, 1166 – 1172

16. Pardeep Kumar, Sushil Kumar Tripathi,Chang-Po Chen, Neil Mehta, Bishnuhari Paudyal, Eric Wickstrom, Mathew L. Thakur*. Evaluation of a PACAP peptide analogue labeled with⁶⁸Ga using two different chelating agents.Cancer Biother. Radiopharm. 2016 31(1):29-36.

17. Mahesh V. Sonar,Matthew E. Wampole,Yuan-Yuan Jin,Chang-Po Chen,Mathew L. Thakur,Eric Wickstrom*.Fluorescence detection of KRAS2 mRNA hybridization in lung cancer cells with PNA-peptides containing an internal thiazole orange.Bioconj. Chem., 2014,25, 1697-1708.

18. Paudyal, B.*, Zhang, K.,Chen, C.P., Metha, N., Wampole, M.E., Mitchell, E. P., Gray, B. D., Mattis, J. A., Park, K.Y., Thakur, M. l., and Wickstrom, E. Determining efficacy of breast cancer therapy by PET imaging ofHER2mRNA.Nucl. Med. Biol.2013, 40, 994-999.

19. Sanders, J. M., Wampole, M. E.,Chen, C.P., Thakur, M. L., and Wickstrom, E*. Effects of hypoxantine substitution in peptide nucleic acids targetingKRAS2oncogenic mRNA molecules: theory and experiment.J. Phys. Chem. B.2013117(39):11584–11595.

20. Sethi ,D.;Chen, C.P.; Jing, R.Y.; Thakur, M.L., and Wickstrom, E*. Fluorescent peptide-PNA chimeras for imaging monoamine oxidase A mRNA in neuronal cells.Bioconj. Chem, 2012, 23(2):158-163.

21. Thakur, M. L.*；Zhang, K.; Paudyal, B.; Devakumar, D.; Covarrubias, M.;Chen, C.-P.; Gray, B. D.; Wickstrom, E.; Pak, K.-Y. Targeting apoptosis for optical imaging of infection.Mol. Imag. and Biol.,2012, 14(2), 163-171.

22. Wickstrom, E.;Chen, C.-P.; Devadhas, D.; Wampole, M.; Jin, Y.-Y.; Sanders, J. M.; Kairys, J. C.; Ankeny, M. L.; Hu, R.; Barner, K. E.; Steiner, K. V.; Thakur, M. L.* Three dimensional projection environment for molecular design and surgical simulation.Studies in Health Technol. and Inform.2011, 163:691-695.

23. Chen, C. P.; Wickstrom, E*.Self-Protecting Bactericidal Titanium Alloy Surface Formed by Covalent Bonding of Daptomycin Bisphosphonates.Bioconj. Chem.2010, 21(11), 1978–1986.

24. Chen, C. P.; Kim, J.; Liu, D.; Rettig, G. R.; McAnuff, M. A.; Martin, M. E.; and Rice, K. G.* Synthetic PEGylated Glycoproteins and Their Utility in Gene Delivery.Bioconj. Chem. 2007, 18(2), 371-378.

25. Cesarone, G.; Edupuganti, O. P.;Chen, C. P.;Wickstrom, E*. Insulin receptor substrate 1 knockdown in human MCF7 ER+ breast cancer cells by nuclease-resistant IRS1 siRNA conjugated to a disulfide-bridged D-peptide analog of insulin-like growth factor 1.Bioconj. Chem. 2007, 18(6), 1831-1840.

26. Chen, C. P.; Zeiger A. R.; Wickstrom E. Bactericidal activity of extended 9-glycyl-amido-minocycline.Bioorg. Med . Chem. Lett.2007,17, 6558-6562.

27. Chen, C. P.; Kim, J.; Steenblock, E.; Liu, D.; and Rice, K. G*.Gene Transfer with Poly-Melittin Peptides.Bioconj. Chem, 2006, 17(4), 1057-1062.

28. Kim, J.;Chen, C. P.; Rice, K. G*.The Proteasome Metabolizes Peptide-Mediated Nonviral Gene Delivery Systems.Gene Ther.2005, 12(21), 1581-1590.

29. Chen, C. P.; Park, Y.; Rice, K. G. * An Improved Large-Scale Synthesis of PEG-Peptides for Gene Delivery.J. Pept. Res.(changed name toChemical Biology and Drug Design,) 2004,64(6),237-243.

30. Chen, C. P.; Zhang, L. R.; Peng, Y. F.; Wang, X. B.; Wang, S. Q.; Zhang, L. H.* A Concise Method for the Preparation of Peptide and Arginine-Rich Peptide-Conjugated Antisense Oligonucleotide.Bioconj. Chem. 2003,14(3),532-538.

31. Chen, C. P.;Li, X. X.; Zhang, L. R.; Min, J. M.; Chan, J. Y. W.; Fung, K. P.; Wang, S. Q.; Zhang, L. H.* Synthesis of Antisense Oligonucleotide-peptide conjugate Targeting to GLUT-1 in HepG-2 and MCF-7 Cells.Bioconj. Chem. 2002,13(3), 525-529.

32. Chen, C.P.;Min, J.M.; Zhang, L.H.* Synthesis and Properties of Peptide-Oligonucleotide Conjugates.Prog. Biochem. Biophys.2001,28(6),783-787.