白大昌

白大昌博士，副教授，硕士生导师

本科郑州大学化学系，博士毕业于中国科学院上海有机化学研究所，获2020年“Thieme Chemistry Journal Award”国际学术期刊奖，2020年河南省优秀青年基金，邮箱地址：baidachang@126.com.

教育经历：

2005.09 - 2009.07:郑州大学，化学专业，理学学士

2009.09 - 2014.07:中国科学院上海有机化学研究所，有机化学专业，理学博士（硕博连读），导师：侯雪龙 研究员

工作经历：

2014.07 - 2015.08:中科院上海有机所金属有机国家重点实验室，助理研究员

2015.10–2016.10:美国内布拉斯加医学研究中心，博士后

2016.11-2020.04：betway官方app，讲师

2020.04-至今：betway官方app ，副教授

研究兴趣和领域：

1，发展以绿色合成化学为导向的新反应方法和技术，研究过渡金属催化（铜，镍，铑，钯）的新型反应模式，包括不对称催化反应体系。

2，致力于新反应方法学的发展及其选择性调节与控制，将发展的方法应用到药物分子的合成中。

近年来主持的主要科研项目:

1，国家自然科学基金-青年项目，铜催化肟酯与缺电子烯烃的环加成反应，2019-2021，26万

2.河南省优秀青年科学基金，过渡金属催化不对称C-C/C-O键活化反应研，2020-2023，25万元

3，河南省高等学校重点科研项目计划，具有C2对称的手性联苯类环戊二烯基铑络合物的合成及其应用研究，2018-2019，5万

代表性论文：

1.Bai, Da-Chang.*;Wu,Fen.; Chang, Ling-Na.;Wang, Man-Man.; Wu, Hao.;Chang, Jun-Biao.*Highly Regio- and Enantioselective Hydrosilylation ofgem-Difluoroalkenesby Nickel Catalysis.Angew. Chem. Int. Ed.2022,61, e202114918.(IF =15.336, Highlight bySynfacts2022, 18, 0398)

2.Bai, Da-Chang.*;Yu, Yan-Jiang.; Guo, Hai-Ming.; Chang, Jun-Biao.; Li, Xing-Wei.* Nickel(0)-Catalyzed Enantioselective [3+2] Annulation of Cyclopropenones anda,b-Unsaturated Ketones/Imines.Angew. Chem. Int. Ed.2020,59, 2740-2744.(IF =12.257, Highlight bySynfacts2020.16.641)

3.Bai, Da-Chang.; Wang, Xue-Li.; Zheng, Guang-Fan.; Li, Xing-Wei.* Redox-Divergent Synthesis of Fluoroalkylated Pyridines and 2-Pyridones through Cu-Catalyzed N-O Cleavage of Oxime Acetates.Angew. Chem. Int. Ed.2018,57, 6633-6637.(IF =12.257)

4.Bai,Da-Chang.*;Xu, Teng.;Ma, Chao-Rui.;Zheng, Xin.;Liu, Bing-Xian.;Xie, Fang.;Li, Xing-Wei.* Rh(III)-Catalyzed Mild Coupling of Nitrones and Azomethine Imines with Alkylidenecyclopropanes via C−H Activation: Facile Access to Bridged Cycles.ACS Catal.2018,8, 4194-4200.(IF = 11.384)

5.Bai, Da-Chang.^(#); Xia, Jin-Tao.^(#); Song, Fang-Fang .; Li, Xue-Yan .; Liu, Bing-Xian.; Liu, Li-Hong.; Zheng, Guang-Fan.; Yang, Xi-Fa.; Sun, Jia-Qiong, * Li, Xing-Wei.* Rhodium(III)-catalyzed diverse [4 + 1] annulation of arenes with 1,3-enynes via sp³/sp²C–H activation and 1,4-rhodium migration.Chem. Sci.2019,10. 3987-3993.(#: co-first authors,IF = 9.556)

6.Bai, Da-Chang.; Yu, Fei-Le.; Wang, Wan-Ying.; Chen, Di.; Li, Hao.; Liu, Qing-Rong.; Ding, Chang-Hua.; Chen, Bo.*; Hou, Xue-Long.* Palladium/N-heterocyclic carbene catalysed region and diastereoselective reaction of ketones with allyl reagents via inner-sphere mechanism.Nature Communications2016,7,11806-11817.(IF = 12.353)

7. Yu, Fei-Le.^(#);Bai, Da-Chang.^(#); Liu, Xiu-Yan.^(#); Jiang, Yang-Jie.; Ding, Chang-Hua.*; Hou, Xue-Long.* Pd-Catalyzed Allylic Alkylation of gem-Alkyl, Aryl-Disubstituted Allyl Reagents with Ketones: Diastereoselective Construction of Vicinal Tertiary and Quaternary Carbon Centers.ACS Catal.2018, 8, 3317–3321.(#: co-first authors, IF = 11.384)

8.Bai,Da-Chang.;*Liu, Song.; Chen, Jun-Yan.; Yu, Yan-Jiang.; Wang, Man-Man.;Chang, Jun-Biao.; Lan., Yu.;* Li, Xing-Wei.*Mechanistic studies on nickel-catalyzedenantioselective [3 + 2] annulation forγ-butenolide synthesis via C–C activationof diarylcyclopropenones.Org. Chem. Front.,2021,8,3023-3031.

9.Bai, Da-Chang.;* Chen, Jun-Yan.; Zheng, Bing-Bing.; Li, Xue-Yan.; Chang, Jun-Biao*.Catalytic [3+3] Annulation of β-Ketoethers and Cyclopropenonesvia C(sp3)-O/C-C Bond Cleavage under Transition-MetalFree Conditions.Chin. J. Chem.2021,39, 2769—2773

10.Chen,Junyan.;Bai,Da-Chang.;^*Guo,Xiuli.;Wang,Yiyao.;Li,Xingwei.*Diastereodivergent[4+2] Annulation of Biphenylenes with EnonesviaNickel(0)-catalyzed C-C bond Activation.Chin Chem Lett.2022.doi:10.1016/j.cclet.2022.02.079.

11.Cui,Yixin.;Bai,Da-Chang.;*Liu,Bingxian.;Chang,Junbiao.;*Li,Xingwei.*Rh(III)-Catalyzed Acylation of Heteroarenes withCyclobutenonesviaC–H/C–C Bond Activation.Chem. Commun.,2020,56, 15631--15634.

12.Xu, Gui-Qing.; Chen, Qi.; Wu, Fen.;Bai, Da-Chang.;*Chang, Jun-Biao.;* Li, Xing-Wei.*Rh(III)-Catalyzed Chemodivergent Coupling ofN‑Phenoxyacetamides and Alkylidenecyclopropanes via C−HActivation.Org. Lett.2021,23, 2927−2932.

13.Bai, Da-Chang.; Jia, Qing-Qian.; Xu, Teng.; Zhang, Qiu-Qiu.; Wu, Fen.; Ma, Chao-Rui.; Liu, Bing-Xian.; Chang, Jun-Biao.*; Li, Xing-Wei.* Rhodium(III)-Catalyzed C−H Activation of Nitrones and Annulative Coupling with Nitroalkenes.J. Org. Chem.2017, 82, 9877-9884.（IF= 4.849）

14.Bai, Da-Chang.; Liu, Xiu-Yan.; Li, Hao.; Ding，Chang-Hua.*; Hou, Xue-Long.* Tandem Thorpe Reaction/Palladium Catalyzed Asymmetric Allylic Alkylation: Access to Chiral β-enaminonitriles with Excellent Enantioselectivity.Chemistry-An Asian Journal2017,12, 212-215.（IF = 3.692）

15.Bai, Da-Chang.^(#);Wang, Wan-Ying.^(#); Ding, Chang-Hua.; Hou, Xue-Long*. Kinetic Resolution of Allyl Carbonates Using TMSCN as Nucleophile via Pd-Catalyzed Asymmetric Allylic Alkylation.Synlett.2015,26, 1510-1514.(#:co-first authors, IF = 2.419）

16. Li, Xue-Yan.; Yu, Yan-Jiang.; Qi, Ruo-Bing.;Bai, Da-Chang*.Facile access to fluoroalkylated 2-aminopyridines by Cu-catalyzed [3 + 3] couplings of oxime esters with β-CF3 acrylonitrile.Tetrahedron Lett.2020.61, 151858-151861.(IF = 2.259)

17.Cheng, Ruo-Shi.;Bai, Da-Chang.*Enantiodivergent Relay Coupling for Nickel-Catalyzed StereoselectiveFunctionalization of Cyclopropylzinc Reagents.Chin. J. Org. Chem.2021,41, 1746-1748.

18. Dai, Hong-Xue.; Wu, Fen.;Bai, Da-Chang*.Recent Advances in Ni-Catalyzed C-C bond Activation Reactions.Chin. J. Org. Chem.2020.40. 1423-1436.

19.Yang, Si-Qi.; Li, Xin.; Peng, Zhuo-Jin.; Yu, Wen-Yan.; Wang, Guang-Xu.; Jin, Ya-Lan.; Zheng, Bing-Bing.; Dai, Hong-Xue.;Bai, Da-Chang.*Synthesis of Pentafluoroethylated Pyridines via Cu-Catalyzed [3＋3]Cycloaddition Reaction of Oxime Acetates.Chin. J. Org. Chem.2019,39,1623-1629.

20.Huang, Shuai.; Tong, Fei-Fei.;Bai, Da-Chang.;Zhang, Gao-Peng.; Jiang, Yang-Jie.; Zhang, Bo.; Leng, Xue-Bing.; Guo, Yin-Long.; Wan, Xiao-Long.; Zhang, Xin-Gang.;* Ding, Chang-Hua.;* Hou, Xue-Long.* Regio- and enantioselective umpolung gemdifluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand.Nat. Commun.,2021,12, 6551.

21.Tian, Miao-Miao.;Bai,Da-Chang.;Zheng, Guang-Fan.; Chang, Jun-Biao.; Li, Xing-Wei.* Rh(III)-Catalyzed Asymmetric Synthesis of Axially Chiral Biindolyls by Merging C−H Activation and Nucleophilic Cyclization.J. Am. Chem. Soc.2019,141, 9527−9532.

22. Sun, Jia-Qiong.;Bai, Da-Chang.; Wang, Pei-Yuan.; Wang, Kuan.; Zheng, Guang-Fan.; Li, Xing-Wei.*Org. Lett.2019,21, 1789−1793.

23.Wang, Man-Man.;Bai, Da-Chang.; Kong, Ling-Heng.; Liu, Bing-Xian.; Li, Xing-Wei.* Ag(I)-Catalyzed Nucleophilic Addition and Friedel-Crafts Alkylation between α-Oxo Ketene Dithioacetals and Propargylic Carbonates.Org. Lett.2018,20, 7775-7778.