朱功名

时间:2019-10-17浏览:4923设置

朱功名,博士,副教授(内聘),Email:zhugm1201@163.com,办公地点:化北楼N614

2017年毕业于兰州大学,获生物化学与分子生物学博士学位,目前主要从事手性药物和多肽药物的定向合成及关键技术的研究。在Angew. Chem. Int. Ed.ACS Catal.Org. Lett.等期刊发表论文15余篇;主持国家自然科学基金1项,省部级基金2两项。

教育与研究经历:

20079-20116月,betway官方app ,生命科学学院。

20119-20176月,兰州大学,生命科学学院,硕博连读,博士。

20177-20187月,中山大学,特聘副研究员,药物化学研究。

20189-至今,betway官方app ,化学化工学院。

主讲课程:

《药理学》,《生物化学》

研究领域及兴趣:

主要研究领域:手性药物和多肽药物的定向合成及关键技术的开发。

  • 潜在活性分子的不对称合成新策略研究。

  • 活性多肽后修饰及其化学生物学研究。

  • 核酸多肽化学生物学研究。

今年来主持及参与的科研项目:

国家自然科学青年基金,2019-2021年,主持,资助金额:27.5万元。

广东省自然科学基金,2018-2021年,主持,资助金额:10万元。

博士后基金面上项目一等资助,2018-2020年,主持,资助金额:8万元。

betway官方app 博士启动经费,2019-2021年,主持,资助金额:8万。

参与完成国家自然科学青年基金2项,其中一项被评为优秀;参与重点项目一项,面上项目一项。

代表论文:

[1]Gongming Zhu#, Guangjun Bao#, Yiping Li, Wangsheng Sun,* Jing Li, Liang Hong,* and Rui Wang*. Efficient Catalytic Kinetic Resolution of Spiro-epoxyoxindoles with Concomitant Asymmetric Friedel-Crafts Alkylation of Indoles.Angew. Chem. Int. Ed.2017,56, 5332 –5335.

[2] Wangsheng Sun#,Gongming Zhu#, Chongyang Wu, Guofeng Li, Liang Hong,* and Rui Wang*. Organocatalytic Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Azlactones and Methyleneindolinones.Angew. Chem. Int. Ed.2013,52, 8633–8637.

[3]Gongming Zhu#, Yiping Li#, Guangjun Bao, Wangsheng Sun,* Liwu Huang, Liang Hong,* and Rui Wang*.Catalytic Kinetic Resolution of Spiro-Epoxyoxindoleswith 1 Naphthols: Switchable Asymmetric Tandem Dearomatization/Oxa-Michael Reaction and Friedel−Crafts Alkylation of 1 Naphthols at the C4 Position.ACS Catal.2018,8, 1810−1816.

[4]Gongming Zhu, Guangjun Bao, Yiping Li, Junxian Yang, Wangsheng Sun, Jing Li, Liang Hong,* and Rui Wang*. Chiral Phosphoric Acid Catalyzed Asymmetric Oxidative Dearomatization of Naphthols with Quinones.Org. Lett.,2016,18, 5288-5291.

[5]Gongming Zhu, Junxian Yang, Guangjun Bao, Ming Zhang, Jing Li, Yiping Li, Wangsheng Sun,* Liang Hong,* and Rui Wang*. Catalyst-controlled switch of regioselectivity in the asymmetric allylic alkylation of oxazolones with MBHCsChem. Commun.2016,52, 7882-7885.

[6]Gongming Zhu, Wangsheng Sun, Chongyang Wu, Guofeng Li, Liang Hong,* and Rui Wang*. Base-Catalyzed Diastereoselective [3 + 3] Annulation of 3-Isothiocyanatooxindoles and Azomethine Imines.Org. Lett.2013,15, 4988.

[7] Wangsheng Sun,Gongming Zhu, Chongyang Wu, Liang Hong,* and Rui Wang*. “Organo - Metal” Synergistic Catalysis: The 1+1>2 Effect for the Construction of Spirocyclopentene Oxindoles.Chem. Eur. J.2012,18, 13959 – 13963.

[8] Wangsheng Sun, Gongming Zhu, Chongyang Wu, Liang Hong,* and Rui Wang*. An Organocatalytic Cascade Strategy for the Enantioselective Construction of Spirocyclopentane Bioxindoles Containing Three Contiguous Stereocenters and Two Spiro Quaternary Centers.Chem. Eur. J.2012,18, 6737 – 6741.

[9] Wangsheng Sun,Gongming Zhu, Liang Hong,* and Rui Wang*. The Marriage of Organocatalysis with Metal Catalysis: Access to Multisubstituted Chiral 2,5-Dihydropyrroles by Cascade Iminium/Enamine–Metal Cooperative Catalysis,Chem. Eur. J.2011,17, 13958 – 13962.

[10]Ming Zhang,1Wangsheng Sun,1Gongming Zhu, Guangjun Bao, Bangzhi Zhang, Liang Hong,* Min Li,* and Rui Wang*.Enantioselective dearomative arylation of isoquinolines.ACS Catal.2016,6, 5290-5294.

[11]Zhenhua Zhang, Wangsheng Sun,*Gongming Zhu, Junxian Yang, Ming Zhang, Liang Hong,* and Rui Wang*. Chiral phosphoric acid catalyzed enantioselective 1,3-dipolar cycloaddition reaction of azlactones.Chem. Commun.2016,52, 1377-1380.

[12]Wangsheng Sun#,Liang Hong#,Gongming Zhu, Zilong Wang, Xiaojin Wei, Jingman Ni,* and Rui Wang*. organocatalytic michael-michael cascade for the enantioselective construction of spirocyclopentane bioxindoles: control of four contiguous stereocenters.Org. Lett.2014, 16, 544-547.

[13]Guofeng Li,Guangjun Bao,Gongming Zhu,Yiping Li,Liwu Huang,Wangsheng Sun,*Liang Hong* andRui Wang*.Regio- and stereospecific Friedel–Crafts alkylation of indoles with spiro-epoxyoxindoles.Org. Biomol. Chem., 2018,16, 3655-3661.

[14] Bangzhi Zhang, Yiping Li, Guangjun Bao,Gongming Zhu, Jing Li, Lijuan Wang, Bao Zhang, Wangsheng Sun,* Liang Hong,* and Rui Wang*. Regio- and stereoselective ring-opening reaction of spiro-epoxyoxindoles with ammonia under catalyst-free conditions.Green Chem.2017,19, 2107-2110.

[15]Zhixuan Zeng,Xudong Xun,Liwu Huang,Jiecheng Xu,Gongming Zhu,Guofeng Li,Wangsheng Sun,*Liang Hong* andRui Wang*. Catalyst-free tandem halogenation/semipinacol rearrangement of allyl alcohols with sodium halide in water.Green Chem.2018,20, 2477-2480.



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