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郝二军,男, 博士,副教授,药物化学及生物与医药专业硕士生导师, 产学研中心主任,民盟betway官方app 委员会副主委,联系电话:0373-3326335,E-mail:hej@htu.edu.cn
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教育与研究经历: 2014.3-2019.12 betway官方app 化学博士后流动站博士后(合作导师:郭海明 教授) 其中:2014.08-2015.08 受省委组织部派遣河南省博士服务团到许昌豪丰化学科技有限公司挂职副总经理; 2017.10-2019.10 借调betway官方app 科技处大健康中心平台秘书; 2020.12-至今 betway官方app 化学化工学院产学研中心主任。 主讲课程: 1、手性核苷类药物的设计与不对称合成研究; 2、含氮杂环化合物抗肿瘤、抗病毒活性、构效关系及作用机制研究; 3、光催化电催化酶催化不对称合成研究。 近期发表的代表性论文: 16.Er-Jun Hao,Gong-Xin Li,Yu-Ru Liang,Ming-Sheng Xie, Dong-chao Wang, Xiao-Han Jiang,Jia-Yi Cheng,Zhi-Xian Shi, Yang Wang,* Hai-Ming Guo*;Design, Synthesis,and Activity Evaluation of Novel Acyclic Nucleosidesas Potential Anticancer AgentsIn VitroandIn Vivo,J. Med. Chem.2021,64, 2077-2109.(药化领域顶尖期刊,Highlight by CBG和X-MOL,Top, IF8.039)
15.Yuqing Chen; Huaipu Yan; Qian Liao*; Dandan Zhang; Shuangjie Lin;Erjun Hao*; Rukhsana Murtaza;Chenchen Li; Chao Wu; Chunying Duan;Lei shi*;Synthesis of Homoallylic Amines by Radical Allylation of Imines with Butadiene under Photoredox Catalysis,Angew. Chem. Int. Ed.2022,e202204516.(化学领域顶尖期刊,SCI一区,Top,IF16.823)
14.Er-Jun Hao, Dan-Dan Fu, Dong-Chao Wang*, Tao Zhang, Gui-Rong Qu,Gong-Xin Li,Yu Lan*, Hai-Ming Guo*,Chemoselective Asymmetric Dearomative [3+2] Cycloaddition Reactions of Purines withAminocyclopropanes,Org. Chem. Front.2019,6,863-867. (SCI一区,Top, IF5.456) 13.Er-Jun Hao, Gong-Xin Li, Zhen-Zhen Lv, Fu-Sheng Li, Yu-Qing Chen, Shuang-Jie Lin, Cai-Zhe Shi, andLei Shi*,“In-Situ Immobilization” of Multicomponent Chiral Catalyst (MCC) via Non-covalent Interactions for Heterogeneous Asymmetric Hydrogenation Reactions,Org. Chem. Front.2020,7, 345-349.(SCI一区,Top, IF5.456) 12.Erjun Hao*,BinghuiLu,Yonghong Liu, Tianxiao Yang, Huaipu Yan, Xiaobo Ding,YunheJin,LeiShi*,Difunctionalization of 1,3-Butadiene via Sequential Radical Thiol-ene Reaction and Allylation by Dual Photoredox and Titanium Catalysis,Org.Lett.2023,25(27),5094-5099.(SCI一区,Top,IF5.2)
11.Huaipu Yan, Dandan Zhang, Yonghong Liu, Xin Wang, Zhixian Wu, Yunhe Jin, Xiaobo Ding, Jingran Shan,Erjun Hao*, Lei Shi*;Photoredox chromium and cobalt dual catalysis for carbonyl allylation with butadiene via allyl radical intermediates,Org. Chem. Front.2024,DOI:10.1039/d3qo01403g.(SCI一区,IF=5.4,Top) 10.Huaipu Yan,Jing-Ran Shan,Fengzhi Zhang, Yuqing Chen, Xinyi Zhang, Qian Liao,Erjun Hao*, Lei Shi*;Radical Crotylation of Aldehydes with 1,3-Butadiene by Photoredox Cobalt and Titanium Dual Catalysis,Org.Lett.2023, 25,7694-7699.(SCI一区,Top,IF5.2) 9.Shuang-Jie Lin, Yu-Qing Chen, Huai-Pu Yan, Yong-Hong Liu, Yu-Chen Sun,Er-Jun Hao*, Cai-Zhe Shi, Dan-Dan Zhang, Nan Zhu, and Lei Shi*;Activation of Chromium Catalysts by Photoexcited Hantzsch Ester forDecarboxylative Allylation of Aldehydes with Butadiene,Org.Lett.2021, 23(20), 8077–8081.(SCI一区,Top,IF6.072) 8.YonghongLiu,HuaipuYan, YuqingChen,ErjunHao,*LeiShi,*Photoinduced copper-catalyzed selective three-component 1,2-amino oxygenation of 1,3-dienes,Chem.Comm.2023,59,10388-10391.(SCI二区,IF4.9) 7.Jie Ma,Rong Feng, Hao-Lin Zhou,Er-Jun Hao*,Zhen Shi, and Zhi-Bing Dong*,One Pot Synthesis of N,N-diphenyl-2-benzothiazolamines from 1-(2-Iodophenyl)-3-phenylthioureas and Iodobenzenes,J. Org. Chem.2022,87(21),14342–14351.(SCI二区,IF4.198) 6.Xi Wang, Jin-Quan Chen, Xing-Xing Yang,Er-Jun Hao*, Zhi-Bing Dong*,Synthesis of Diaryl Sulfides by Using Tetramethylthiuram Monosulfide (TMTM) as Organosulfur Source: a Practical C(sp2)-S Bond Construction,Eur. J. Org. Chem.2022,e202200015.(IF3.261) 5.Yue-Xiao Wu; Kang Peng, Zhi-Chao Hu, Yong-Hao Fan, Zhen Shi;Er-Jun Hao*; Zhi-Bing Dong*;Iodine-mediated cross dehydrogenation coupling of heterocyclic thiols with amines: an easy and practical formation of S-Nbond,Eur. J. Org. Chem.,2021,43:5889-5894.(IF3.261) 4. Pei-Hua Zhao*, Kuan-Kuan Xiong, Wen-Jun Liang,Er-Jun Hao*,Synthesis, crystal structures and electrocatalytic properties of bridgehead-C- functionalized diiron dithiolate complexes,J. Coord. Chem.2015,68,968-979.
3.Hao, Erjun*, Ding, Xiaobo, Wang, Kexin, Zhou, Honghao, Yang, Qiliang, Shi, Lei*. Recent Progress on [3+2] Ring-Expansion Reaction of Aziridines with Unsaturated Compounds[J]. Chinese Journal of Organic Chemistry,Chin.J.Org.Chem.2023,43:4057-4074. 2.Er-Jun Hao, Qing Zhang, Qi-Ying Zhang*,Gui-Rong Qu, Xi-Ning Yang, Hai-Ming Guo*, Efficient Synthesis of Spirocyclic Nucleosides via Michael-initiated Intermolecular Cyclopropanation Reaction,Chin.J.Org.Chem.2019,39,3237-3243. 1.Er-Jun Hao, Xiao-Han Jiang, Dan-Dan Fu, Dong-Chao Wang*, Ming-Sheng Xie, Hai-Ming Guo, Synthesis of 3-Cyanomethyl Oxoindoles via Palladium- catalyzed Domino Heck/Cyanation Reaction inWater,Chin.J.Org.Chem.2016,36, 2746-2751. 近年来主持的主要科研项目: 2、河南省高等学校重点科研项目(21A150002),2021.01-2022.12; 3、河南省博士后基金项目(一等资助)(2015071),2016.01-2019.12; 4、河南省产学研项目142107000082),2015.01-2018.10; 5、河南省高等教育教学改革研究与实践重点项目(2021SJGLX105),2022.01-2023.12。 6、河南省教育厅教师教育课程改革研究重点项目(2014-JSJYZD-012),2014.07-2016.07; 7、河南省教师教育课程改革一般项目(2020-JSJYYB-026),2020.06-2021.06; 8、企业横向科技合作项目(H20200003),2020.03-2024.03; 9、企业横向科技合作项目(HJX201819),2013.11-2018.10; 10、betway官方app 研究生教育改革与质量提升工程项目:研究生课程思政示范课程项目,现代药剂学选论(XY2023SZ02),2023.03-2025.03。 近年来参加的主要科研项目: 1、国家自然科学基金联合基金重点项目:糖杂环核苷的设计合成、抗肿瘤活性及构效关系研究,U22A20378,2023.01-2026.12,参与,在研; 2、国家自然科学基金:电化学调控的不对称反应合成手性碳环核苷,21602045,2017.01-2019.12,参与(第二参与人),已结题; 3、国家自然科学基金:负载手性催化剂的毛发状纳米载体的设计及其在不对称反应中的应用,21204019,2013.01-2015.12,参与(第二参与人),已结题; 获得荣誉与奖励: 1、国培计划、省培计划等培训项目可持续发展研究与实践,河南省教师教育教学成果奖二等奖(豫教〔2021〕58527); 2、吉西他滨盐酸盐生产新工艺研究,河南省人民政府,河南省科技进步三等奖(证书编号:2012-J-256-R05/06); 3、betway官方app 优秀教师; 4、betway官方app 优秀班主任; 5、betway官方app 优秀实习指导教师; 6、优秀创新创业指导老师奖; 7、betway官方app 文明教师; 8、河南省教育厅优秀科技论文二等奖; 9、化学化工学院优秀共产党员; 10、挑战杯优秀指导老师奖; 11、河南省优秀盟员。
代表性授权国家发明专利: 1、郝二军、郭海明等;[3+2]环加成不对称脱芳构化合成手性非芳香嘌呤核苷的方法,授权专利号:ZL201810894271.4; 2、郝二军、郭海明等;一种磷酸氟达拉滨的制备方法,授权专利号:ZL201610278259.1; 3、郝二军、郭海明等;一种合成2′-螺环基取代的三元碳环核苷的方法,授权专利号:ZL201910374991.2。 4、郭海明、王洋、郝二军等;非环核苷先导化合物及其制备方法和在制药中的应用,授权专利号:ZL202011489709.4。 English version: Dr.Er-Jun Hao School of Chemistry and Chemical Engineering,HenanNormal University Xinxiang, 453007, China E-mail:hej@htu.edu.cn Tel:+86-03733326335. Education and Academic career: Lecturer,HenanNormal University, China(2008) Ph.D.: Nankai University, China (2010, supervisor: Prof. Xiao-Qing Zhu andProf. Jin-Pei Cheng) M.S.: Henan Normal University, China (2005) B.S.: Henan Normal University, China (2002) Major Research Interests: 1. Design and synthesis of chiral nucleoside drugs; 2. Antitumor activity and structure-activity relationship study; 3. PhotocatalyticandElectrocatalysisandEnzyme Catalysisasymmetricsynthesis; |