徐桂清

徐桂清
博士,副教授,药物化学专业和制药工程专业硕士生导师。河南省科技创新杰出青年,河南省高层次人才C类人才。
E-mail:guiqingxu@163.com

教育与研究经历:

1992.09~1996.06betway官方app ,化学专业本科

1996.09~1999.06betway官方app ,有机化学专业硕士

1999.09~~至今 betway官方app ,助教、讲师、副教授

2003.09~2007.06浙江大学,医学博士

主讲课程:

药物化学,药物合成,高等药物化学

研究领域与兴趣:

抗肿瘤药物的设计与合成

药物合成工艺研究

近年来主持的主要科研项目:

1.强力霉素绿色合成关键技术及产业化研究,河南省科技创新杰出青年支持计划(164100510015)

2.盐酸多西环素合成关键技术及产业化研究,河南省科技攻关计划(15210231031

3.硫酸氢氯吡格雷合成新技术研究,河南省产学研项目(122107000011)

4. 2,6-二氯苯并噁唑合成新工艺研究,河南省产学研项目(142107000025)

5.双膦酸盐骨吸收抑制剂新工艺研究及产业化,河南省科技攻关计划(82102330029)

6.卡托普利稀土元素配合物的合成、结构表征、性质及生物活性研究,河南省教育厅基础研究项目(2010B150016)

7. 2,6-二氯苯并噁唑合成新工艺研究(横向项目)

8.硫酸氢氯吡格雷合成关键技术研究(横向项目)

9.吉西他滨盐酸盐生产新工艺研究(横向项目)

10.辛伐他汀铵盐结构确证(横向项目)。

近年来发表论文:

1.Guiqing Xu, Yuan Gao, Bin Sun, Lizeng Peng, Longfei Mao,a Yuqin Jiang, and Qingjie Ding. A convenient synthesis and biological research of novel 5,6,7,8-tetrahydro-1,6-naphthyridin- 2(1H)-one derivatives hydrochloride as cytotoxic agents. Journal of Heterocyclic Chemistry, 2018, 55(9), 2151-2156

2. Yuqin Jiang, Kai Wu, Liming Fan, Jinglin Zhao, Yuqing Yang, Weiwei Zhang* andGuiqing Xu*. Cu(OAc)2.H2O/NH2OH.HCl/CH3COONa: A Facile and Efficient Catalyst System for Copper-catalyzed Azide–Alkyne Click Reactions in Water. Journal of the Chinese Chemical Society, 2018, 65, 505-510.

3.Guiqing Xu, Shen Mao, Longfei Mao*, Yuqin Jiang, Yong Zhou, Jiaxuan Shen, and Wenpei Dong. Study on a New Method for Synthesis of Mirabegron. Journal of Heterocyclic Chemistry, 201754(5)2703-2707

4.Guiqing Xu*, Jinglin Zhao, Yuqin Jiang, Peng Zhang and Wei Li. Design, synthesis and antifungal activity of novel indole derivatives linked with the 1,2,3-triazole moiety via the CuAAC click reaction. Journal of Chemical Research, 2016, 40: 269-272

5.Guiqing Xu*, Shen Mao, Longfei Mao, Yuqin Jiang*, Peng Zhang and Wei Li. Design, synthesis, and antifungal evaluation of novel 1,4-disubstituted 1,2,3-triazoles containing indole framework. Zeitschrift fur Naturforschung Section B, 2016; 71(9)b: 953-958

6. Yuqin Jiang*, Xing He, Weiwei Zhang, Xingfeng Li, Niu Guo, Yaru Zhao,Guiqing Xu*and Wei Li. Metallic copper wire: a simple, clear and reusable catalyst for the CuAAC reaction in supercritical carbon dioxide. RSC Adv., 2015, 5, 73340-73345.

7.Guiqing Xu*, Duanyang Kong, Wei Li, Wenjing Xu and Yuqin Jiang*. Synthesis of maleimide derivatives via CuAAC click chemistry and biological evaluation of their antitumor activity against cancer cell lines Journal of Chemical and Pharmaceutical Research, 2014, 6(5):947-951

8. Yuqin Jiang*, Duanyang Kong, Jinglin Zhao, Qinghua Qi, Wei Li andGuiqing Xu*. Cu(OAc)2.H2O/NH2NH2.H2O: an efficient catalyst system that in situ generates Cu2O nanoparticles and HOAc for Huisgen click reactions. RSC Advances, 2014, 4, 1010-1014

9. Yuqin Jiang*, Duanyang Kong , Jinglin Zhao , Weiwei Zhang , Wenjing Xu*, Wei Li ,Guiqing Xu*.simple, efficient thermally promoted protocol for Huisgen-click reaction catalyzed by 10.CuSO4.5H2O in water. Tetrahedron Letter, 2014 (55) : 2410–2414

10. Ruina Huo,Guiqing Xu, Xiaoying Jiang, Yao Ge, Zaikun Xue, Fengling Cui. Calf Thymus DNA Binding Studies of the New Neodymium–Naproxen Complex. Journal of Biochem Molecular Toxicology, 2012, 26(5): 193-198

11. Qing Ye,Guiqing Xu,Dan Lv , Zhe Cheng, Jia Li , Yongzhou Hu. Synthesis and biological evaluation of novel 4-azaindolyl-indolyl-maleimides as glycogen synthase kinase-3b (GSK-3b) inhibitors. Bioorganic & Medicinal Chemistry. 2009, 17: 4302-4312

12.Guiqing Xu, Qiaojun He, Bo Yang and Yongzhou Hu. Synthesis and Antitumor Activity of Novel 4-Chloro-3-Arylmaleimide Derivatives. Letters in drug design and discovery, 2009, 6(1)51-55

13.Guiqing Xu,Chong Zhang, Lei Zhang, XingLu Zhou, Bo Yang, QiaoJun He,YongZhou Hu. Synthesis,cytotoxicity and protein kinase C inhibition of arylpyrrolylmaleimidesArchiv der Pharmazie2008341(5), 273-280

14.Guiqing Xu,Peng Guo, Chong Zhang, QiaoJun He, Bo Yang, YongZhou Hu, Synthesis and Cytotoxicity of IndolopyrrolemaleimidesChemical & Pharmaceutical Bulletin, 2007, 55(9), 1302-1307

15.徐桂清,胡永洲,张冲,何俏军,杨波.吲哚马来酰亚胺类化合物的合成及其抗肿瘤活性.有机化学, 2009, 29(6): 916-923

授权发明专利:

1.徐桂清,高原等.一种强力霉素的高效制备方法(ZL 2017102271420.5.授权日期:2019-05-31

2.徐桂清,张银贵等.一种强力霉素的制备方法(ZL 201710227183.4.授权日期:2019-05-17

3.李伟,徐桂清.一种3,3,5,5-四甲基联苯胺的制备方法(ZL 201611014357.0.授权日期:2019-02-01

4.徐桂清,姜玉钦等.一种硫普罗宁及其锌配合物的制备方法(ZL 201610117530.X.授权日期:2018-07-13

5.徐桂清,贾淑红等.一种测定(4R, 6R)-6-胺乙基-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯含量的方法(ZL 201510497319.4.授权日期:2017-01-25

6.徐桂清, 孔端阳等.具有抗菌活性的马来酰亚胺-1,2,3-三氮唑类化合物及其制备方法(ZL 201310384113.1.授权日期:2014-08-20

7.徐桂清,王晓锦等.具有抑菌活性的烯唑醇-1,2,3-三氮唑类化合物及其制备方法(ZL 201310005915.7.授权日期:2015-05-06

8.徐桂清,姜玉钦等.具有抑菌活性的吲哚及其衍生物-三氮唑类化合物及其制备方法(ZL 201210328217.6.授权日期:2014-02-12

9.姜玉钦,徐桂清.具有抗真菌活性的丹皮酚-1,2,3-三氮唑类化合物及其制备方法(ZL 201210326824.9.授权日期:2014-08-13

10.姜玉钦,徐桂清.具有抑菌活性的苯并咪唑-1,2,3-三氮唑类化合物及其制备方法(ZL 201310005920.8.授权日期:2014-03-19

科技成果鉴定:

1.膦酸盐骨吸收抑制剂新工艺研究及产业化,河南省科技厅鉴定(豫科鉴委字〔2009〕第524号)

2.吉西他滨盐酸盐生产新工艺研究,河南省科技厅鉴定(豫科鉴委字〔2009〕第523号)

3.生物合成(R-邻氯扁桃酸甲酯关键技术研究(豫科鉴委字〔2013〕第1530

荣誉与奖励

1.河南省科技创新杰出青年

2.吉西他滨盐酸盐生产新工艺研究,河南省科技进步三等奖(第一完成人),2013

3.曲克芦丁合成关键技术创新及产业化,河南省教育厅科技成果一等奖(第四完成人),2020

4.多次获得betway官方app 优秀教师、“三育人”先进个人、优秀指导教师等




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