姜玉钦 - betway官方app

姜玉钦，河南镇平人。博士，教授，药物化学、生物与医药硕士生导师，教务处副处长。E-mail:yuqinjiang2018@163.com。

河南省科技创新杰出青年

河南省教育厅学术技术带头人

河南省手性醇类药物工程技术研究中心主任

化学制药及生物医用材料河南省工程实验室主任

河南省药学会药物化学专业委员会副主任委员

九三学社新乡市第八届监督委员会委员

新乡市第九批优秀专家

河南省知识产权专家库专家

教育经历：
1998.09-2002.07betway官方app 化学与环境科学学院，精细化工专业，工学学士，指导教师娄向东教授；
2002.09-2005.07betway官方app 化学与环境科学学院，应用化学专业，工学硕士，导师李伟教授；
2005.09-2008.12南开大学高分子化学研究所，高分子化学与物理专业，理学博士，导师陈永胜教授。

工作经历：

2009.01-2010.12郑州大学化学系，分析化学博士后，合作导师屈凌波教授；

2011.01-2015.03betway官方app 化学与环境科学学院，讲师，硕士生导师；

2015.04-2021.03betway官方app 化学化工学院，副教授；

2021.04-至今betway官方app 化学化工学院，教授。

讲授课程：

《药物分析》《化学制药工艺学》《药物分析及制药检测常用技术》《药物分析实验》《药物分析综合实验》

研究领域与兴趣：

1、抗肿瘤创新药物

2、药物合成工艺

3、有机反应方法学

4、高分子生物医用材料

近年来主持的主要科研项目:
1、河南省科技创新杰出青年人才支持计划：高品质曲克芦丁原料药合成关键技术及产业化研究，2017.01-2018.12，30万元。

2、河南省产学研项目：维脑路通原料药生产新工艺及产业化研究，2015.01-2016.12，25万元。

3、横向项目：曲克芦丁化学合成新工艺，2014.05-2016.12，50万元。

4、横向项目：阿托伐他汀钙原料药新工艺研究，2017.11-2021.12，100万元。

5、横向项目：抗肿瘤新药的研究与开发，2019.01-2024.01，100万元。

6、横向项目：抗过敏药物工艺开发及DMF文件制作，2019.10-2025.02，150万元。

7、河南省高等教育教学改革研究与实践重点项目：生物与医药硕士创新及联合培养基地建设研究与实践，2019-2021，3万元。

8、河南省专业学位研究生精品教学案例项目：制药工艺与技术，2021-2022，3万元。

9、betway官方app 优秀科技创新团队：药物研究与开发创新团队，2022-2024，30万元。

10、河南省高等学校重点科研项目计划基础研究专项：2023-2025，30万元。

近年来发表论文：

29、Chunhua Ma, Xiaofeng Li, Xiya Chen, Xing He, Shuting Zhang,*Yuqin Jiang,*and Bing Yu*, Photocatalytic umpolung strategy for the synthesis of α-amino phosphine oxides and deuterated derivatives.Organic Letters,2023,25, 8016-8021.

28、Danfeng Wang, Jin Wang, Chunhua Ma*,Yuqin Jiang,* andBing Yu*, C-3 functionalization of 2-aryl-2h-indazoles under photo/electrocatalysis.Chinese Journal of Organic Chemistry,2022, 42, 4024-4036.

27、Chunhua Ma, Yu Tian, Junyan Wang, Xing He,Yuqin Jiang,*andBing Yu,* Visible-Light-driven transition-metal-free site-selective access to isonicotinamides.Organic Letters,2022, 24, 8265-8270.

26、Chunhua Ma, Hui Meng, Jing Li, Xianguang Yang,Yuqin Jiang,*andBing Yu,* Photocatalytic transition-metal-free direct 3-acetalation of quinoxaline-2(1H)-ones.Chinese Journal of Chemistry,2022, 40, 2655-2662.

25、Jin Wang, Qingyuan Song, Xing He, Chunhua Ma,*Yuqin Jiang,* and Jing Fan,* Visible light-promoted, photocatalyst-free decarboxylative alkylation of 2H-indazoles viaelectron donor-acceptor complex activation.New Journal of Chemistry,2022,46, 16436-16439.

24、Chunhua Ma, Hui Meng, Xing He,Yuqin Jiang* and Bing Yu*,Visible-light-promoted transition-metal-free construction of 3-perfluoroalkylated thioflavones,Frontiers in Chemistry,2022,10:953978.

23、Chunhua Ma, Lu Zhao, Xing He,Yuqin Jiang*, and Bing Yu*, Visible-light-induced direct 3-ethoxycarbonylmethylation of 2-qaryl-2H-indazoles in water,Organic Chemistry Frontiers,2022, 9, 1445-1450.

22、Chunhua Ma, Yu Ji, Jie Zhao, Xing He, Shuting Zhang,*Yuqin Jiang,*and Bing Yu*. Transition-metal-free three-component acetalation-pyridylation of alkenes via photoredox catalysis.Chinese Journal of Catalysis,2022, 43, 571-583.

21、Chunhua Ma*, Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu,*Yuqin Jiang,*and Qingjie Ding*. Discovery of1-amino-1h-imidazole-5-carboxamidederivatives as highly selective, covalent Bruton’s Tyrosine Kinase (BTK) inhibitors.Journal of Medicinal Chemistry,2021,64(21), 16242-16270.

20、Dandan Zhang^#, Guiqing Xu^#, Jie Zhao^#, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang, Chunhua Ma*,Yuqin Jiang*, Qingjie Ding*. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase.European Journal of Medicinal Chemistry,2021, 225,113724(1-23).

19、Chunhua Ma, Ming Chen, Zhiwen Feng, Yan Zhang, Jin Wang,Yuqin Jiang,*and Bing Yu*. Functionalization of imidazo[1,2-a]pyridines via radical reactions.New Journal of Chemistry,2021, 45, 9302-9314.

18、Chunhua Ma,Zhiwen Feng, Jing Li,Dandan Zhang, Wei Li,Yuqin Jiang*and Bing Yu*. Photocatalytic transition-metal-free direct 3-alkylationof 2-aryl-2h-indazoles in dimethyl carbonate,Organic Chemistry Frontiers,2021, 8, 3286-3291.

17、Yusang Xia, Ling Yan, Guojiang Mao, Wenli Jiang, Wenxin Wang, Yongfei Li,Yuqin Jiang*,and Chunyan Li*. A novel HPQ-based fluorescent probe for the visualization of carbon monoxide in zebrafish,Sensors and Actuators B: Chemical,2021, 340, 129920 (1-7).

16、Yuqin Jiang, Pengfei Li, Jie Zhao, Bingxian Liu*, and Xingwei Li*. Iodonium ylides as carbene precursors in Rh(III)-catalyzed C-H activation,Organic Letters,2020,22(19), 7475-7479.

15、Yuqin Jiang, Lu Jiang, Yuanyuan Pang, Dan Kai, Xiaoshan Fan*, and Zibiao Li*. Surface migration of fluorinated-siloxane copolymer with unusual liquid crystal behavior for highly efficient oil/water separation,ACS Applied Polymer Materials,2020, 2, 3612-3620.

14、Yuqin Jiang,Jing Li, Zhiwen Feng, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*.Ethyleneglycol: a green solvent forvisible light-promoted aerobic transition metal-free cascade sulfonation/cyclization reaction,Advanced Synthesis & Catalysis,2020,362(13), 2609-2614.

13、Yuqin Jiang, Pengfei Li, Juanjuan Wang, Jie Zhao, Yang Li, Yawen Zhang, Junbiao Chang*, Bingxian Liu* and Xingwei Li*. Rh(III)-catalyzed coupling of acrylic acids and ynenones via oleﬁnic C-H activation and Michael addition,Organic Letters,2020, 22(2), 438-442.

12、Yuqin Jiang, Yanyan Li, Tingting Yang, Xin Shi*, Huajun Suo, Weiwei Zhang* Guiqing Xu and Wei Li*. Design, synthesis, and antilung adenocarcinoma activity research of novel paeonol Schiff base derivatives containing a 1,2,3-triazole moiety,Journal of the Chinese Chemical Society,2020, 67(1), 165-171.

11、TingtingYang, Xin Shi, Libing Guo, Shaohua Gu, Weiwei Zhang, Guiqing Xu, Wei Li* andYuqin Jiang*. Design, synthesis, and antitumor activity of novel paeonol derivatives containing the 1,4-benzoxazinone and 1,2,3-triazole moieties,Journal of Chemical Research,2019, 43(7-8), 241-247.

10、Yuqin Jiang, Kai Wu, Qian Zhang,* Keqing Li, Yanyan Li, Pengyang Xin, Weiwei Zhang and Haiming Guo*.A dual-responsive hyperbranched supramolecular polymer constructed by cooperative host-guest recognition and hydrogen-bond interactions,Chemical Communications,2018,54, 13821-13824.

9、Yuqin Jiang, Kai Wu, Liming Fan, Jinglin Zhao, Yuqing Yang, Weiwei Zhang* and Guiqing Xu*. Cu(OAc)₂H₂O/NH₂OH·HCl/CH₃COONa: A facile and efficient catalyst system for copper-catalyzed azide-alkyne click reactions in water,Journal of the Chinese Chemical Society,2018,65, 505-510.

8、Yuqin Jiang, Shuhong Jia, Xiyong Li, Yamin Sun, Wei Li, Weiwei Zhang, Guiqing Xu. An efficient NaHSO₃-promoted protocol for chemoselective synthesis of 2-substituted benzimidazoles in water,Chemical Papers,2018, 72, 1265-1276.

7、Yuqin Jiang, Huajun Suo, Yaru Zhao, Xiyong Li, Yamin Sun, Xingfeng Li, Wenpei Dong, Wei Li, Weiwei Zhang* and Guiqing Xu. DBU-promoted Cu(OAc)₂·H₂O-catalysed coupling reactions of aryl iodides and sodium azide,Journal of Chemical Research,2018, 42, 247-250.

6、Yuqin Jiang, Kai Wu, Xuxia Tan, Dandan Zhang, Wenpei Dong, Wei Li, Guiqing Xu and Weiwei Zhang*. [bmim]PF₆/KOH: a recyclable catalytic system for an azide-arylacetaldehyde [3+2] cycloaddition,Journal of Chemical Research,2017, 41, 631-635.

5、Yuqin Jiang, Shuhong Jia, Xiyong Li, Yamin Sun, Wei Li, Weiwei Zhang* and Guiqing Xu*. Design, synthesis, and antifungal evaluation of novel benzoxazole derivatives containing a 1,2,3-triazole moiety,Journal of the Chinese Chemical Society,2017, 64, 1197-1202.

4、Yuqin Jiang,* Xingfeng Li, Yaru Zhao, Shuhong Jia, Mingrui Li, Zhiqi Zhao, Ruili Zhang, Wei Li and Weiwei Zhang*. An efficient CuI/DBU-catalyzed one-pot protocol for synthesis of 1,4-disubstituted 1,2,3-triazoles,RSC Advances,2016, 6, 110102-110107.

3、Yuqin Jiang,* Xing He, Weiwei Zhang, Xingfeng Li, Niu Guo, Yaru Zhao, Guiqing Xu* and Wei Li. Metallic copper wire: a simple, clear and reusable catalyst for the CuAAC reaction in supercritical carbon dioxide,RSC Advances,2015, 5, 73340-73345.

2、Weiwei Zhang, Baoqi Ren,Yuqin Jiang* and Zhiguo Hu*. Carboxymethylpullulan promoted Cu₂O-catalyzed Huisgen-click reaction,RSC Advances,2015, 5,12043-12047.

1、Weiwei Zhang, Xing He, Baoqi Ren,Yuqin Jiang* and Zhiguo Hu*. Cu(OAc)₂·H₂O-an efficient catalyst for Huisgen-click reaction in supercritical carbon dioxide,Tetrahedron Letters,2015, 56, 2472-2475.

授权专利：

11、姜玉钦等，一种高含量曲克芦丁的制备方法，ZL201810308308.0，2023年。

12、姜玉钦等，一种表达COVID-19抗原的表达载体及基因工程乳酸菌口服疫苗的构建方法，ZL202010677960.7，2023年。

11、姜玉钦等，一种2-(2-苯基-2H-吲唑-3-基)乙酸酯类化合物的水相光催化制备方法，ZL202111024843.1，2023年。

10、姜玉钦等，WO2022012550 A1, 2022年。

9、姜玉钦等，WO2021110142 A1, 2021年。

8、姜玉钦等，WO2020228637 A1, 2020年。

7、姜玉钦等，一种阿托伐他汀钙中间体ATS-9的纯化方法，ZL 201811169986.X，2020年。

6、姜玉钦等，一种高纯度福多司坦的制备方法，ZL 201810560947.6，2020年。

5、姜玉钦等，一种高含量曲克芦丁的制备方法，ZL 201710119984.9，2020年。

4、姜玉钦等，一种奈拉西坦的制备方法，ZL 201410766319.5，2017年。

3、姜玉钦等，一种采用自吸式搅拌高压釜制备曲克芦丁的方法，ZL 201410766698.8，2017年。

2、姜玉钦等，具有抑菌活性的烯唑醇-1,2,3-三氮唑类化合物及其制备方法，ZL 201410184618.8，2016年。

1、姜玉钦等，一种沙坦联苯的制备方法，ZL 201310383875.X，2015年。

科技奖励：

3、曲克芦丁关键技术创新及产业化应用，河南省科技进步奖二等奖，第十完成人，2023年。

2、曲克芦丁合成关键技术创新及产业化，河南省教育厅科技成果奖一等奖，第一完成人，2020年。

1、阿托伐他汀钙关键技术研究与产业化，河南省科学技术进步奖叁等奖，第四完成人，2014年。

个人荣誉：

学术桥评审专家库成员、河南省化学会常务理事、新乡市九三学社“社内监督工作先进个人”“参政议政工作先进个人”；新乡市第九批优秀专家；河南省抗击新冠肺炎疫情先进个人；河南省科技创新杰出青年；河南省高层次人才C类；河南省优秀硕士学位论文指导教师；河南省高校科技管理工作先进工作者；河南省高等学校优秀共产党员；新乡市九三学社抗击新冠肺炎疫情先进个人暨社会服务先进个人；中国“互联网+”大学生创新创业大赛全国铜奖指导教师；betway官方app 首届“卢锦梭师德楷模奖教金”获得者、“急难险重先进个人”“青年五四奖章”“优秀教师”“三育人先进个人”“研究生优秀指导教师”等。

Individual Profile:Yuqin Jiang, PhD, associate professor,School of Chemistry and Chemical Engineering, Henan Normal University.E-mail:yuqinjiang2018@163.com.

Education:
1998.09-2002.06 School of Chemistry and Environmental Sciences,Henan Normal University,Bachelor of Engineering;
2002.09-2005.06 School of Chemistry and Environmental Sciences,Henan Normal University,Masterof Engineering;
2005.09-2008.12Institute of Polymer Chemistry,Nankai University,Doctor of Science.

Professional Experience:

2011.01, School of Chemistry and Environmental Sciences,Henan Normal University;

2015.04,School of Chemistry and Chemical Engineering, Henan Normal University,associate professor;

2009.01-2011.01, Department Chemistry, Zhengzhou University, analytical chemistry postgraduate.

Research Interests:

1、Anti-tumor Drug Design and Synthesis

2、Pharmaceutical Technology

3、Methodology ofOrganicSynthesis

4、Functional Polymer Materials

Research Support:
1、Innovative Talents Program of Henan Province (No. 174100510025):Research on the key technology and industrialization of high-purity bulk drug troxerutin,Role: PI, 2017.1-2018.12,￥300K.

2、Research on the new technology and industrialization of drug Venoruton,Role: PI, 2015.1-2016.12,￥250K.

3、New synthetic process fortroxerutin, Role: PI, 2014.5-2016.12,￥500K.

4、New synthetic process for atorvastatin calcium, Role: PI, 2017.11-2021.12,￥1000K.

5、Anti-tumor drug design and synthesis, Role: PI, 2019.01-2022.01,￥1000K.

6、New synthetic process for antiallergic agent,Role: PI, 2019.10-2021.02,￥1500K.

7 、Postgraduate Education Reform Project of Henan Province,Role: PI,2019-2021,￥30K.

Representative Publications:

29、Chunhua Ma, Xiaofeng Li, Xiya Chen, Xing He, Shuting Zhang,*Yuqin Jiang,*and Bing Yu*, Photocatalytic umpolung strategy for the synthesis of α-amino phosphine oxides and deuterated derivatives.Organic Letters,2023,25, 8016-8021.

28、Danfeng Wang, Jin Wang, Chunhua Ma*,Yuqin Jiang,* and Bing Yu*, C-3 functionalization of 2-aryl-2h-indazoles under photo/electrocatalysis.Chinese Journal of Organic Chemistry,2022, 42,4024-4036.

25、Jin Wang, Qingyuan Song, Xing He, Chunhua Ma,*Yuqin Jiang,* Jing Fan,* Visible light-promoted, photocatalyst-free decarboxylative alkylation of 2H-indazoles viaelectron donor-acceptor complex activation.New Journal of Chemistry,2022,46, 16436-16439.

24、 Chunhua Ma, Hui Meng, Xing He, Yuqin Jiang * and Bing Yu*, Visible-light-promoted transition-metal-free construction of 3-perfluoroalkylated thioflavones,Frontiers in Chemistry ,2022, 10:2022.953978.

23、Chunhua Ma, Lu Zhao, Xing He,Yuqin Jiang*, Bing Yu*, Visible-light-induced direct 3-ethoxycarbonylmethylation of 2-qaryl-2H-indazoles in water,Organic Chemistry Frontiers,2022,DOI: 10.1039/D1QO01870A.

20、Dandan Zhang^#, Guiqing Xu^#, Jie Zhao^#, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang, Chunhua Ma*,Yuqin Jiang,*and Qingjie Ding*. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase.European Journal of Medicinal Chemistry,2021,225,113724(1-23).

18、Chunhua Ma,Zhiwen Feng, Jing Li,Dandan Zhang, Wei Li,Yuqin Jiang,*and Bing Yu*. Photocatalytic transition-metal-free direct3-alkylationof 2-aryl-2h-indazoles in dimethyl carbonate,Organic Chemistry Frontiers,2021,2021, 8, 3286-3291.

17、Yusang Xia, Ling Yan, Guojiang Mao, Wenli Jiang, Wenxin Wang, Yongfei Li, andYuqin Jiang*,and Chunyan Li*. A novel HPQ-based fluorescent probe for the visualization of carbon monoxide in zebrafish,Sensors and Actuators B: Chemical,2021,340, 129920 (1-7).

16、Yuqin Jiang, Pengfei Li, Jie Zhao, Bingxian Liu,* and Xingwei Li*. Iodonium ylides as carbene precursors in Rh(III)-catalyzed C-H Activation,Organic Letters,2020,22(19), 7475-7479.

2、Weiwei Zhang, Baoqi Ren,Yuqin Jiang* and Zhiguo Hu*. Carboxymethylpullulan promoted Cu₂O-catalyzed Huisgen-click reaction,RSC Advances,2015, 5,12043-12047.