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仉华 河北省石家庄市人；博士，教授,博士生导师,2017年获得国家优秀青年科学基金资助，河南省优秀专家，河南省模范教师，河南省学术技术带头人，河南省高校科技创新团队带头人，河南省教育厅学术技术带头人，河南省高校科技创新人才，新乡市创新人才。中国感光学会光学传感与诊疗专业委员会委员、河南省化学会理事、河南省青年科技工作者协会理事兼高校界别工作委员会秘书长。 E-mail:zhanghua1106@163.com |
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讲课程： 分析化学、仪器分析、染料功能调控、荧光分析法 研究领域： 染料功能调控与生物成像； 识别特殊蛋白质/酶、核酸的新型双光子荧光染料的设计及其生物应用； 用于疾病诊断的双光子荧光技术的研究和开发； 近年来主持的主要科研项目： 1、生化分析与生物成像，国家优秀青年科学基金项目，2018.1-2020.12，项目编号：21722501 2、反应型Sequential-ICT荧光探针及双功能酶活性的生化分析与成像，2020.1-2021.12，204200510006 3、生物酶靶向功能有机小分子双光子荧光染料的构建及其在疾病诊断成像中的应用研究，国家自然科学基金项目，2015.1-2017.12，项目编号：21402043 4、有机小分子双光子荧光染料的功能调控及其在疾病诊断中的应用，河南省基础与前沿技术研究计划资助项目，2014.2-2015.8，项目编号：142300410421 5、耐候型悬乳聚合染料/颜料微球彩色墨粉的构建及其在图像输出中的应用，河南省重点科技攻关计划项目,2015.1-2017.12，项目编号：152102210082 6、用于大幅面打印的耐晒型酞菁类青色染料合成工艺的研究及其应用，河南省高等学校重点科研项目,2015.1-2016.12，项目编号：15A150017 7、端基官能化荧光染料的构建及其在肿瘤细胞亚结构成像中的应用研究，新乡市科技创新人才计划，2015.8-2017.8，项目编号：RC15002 8、光致开关末端功能化的有机小分子荧光染料的构建及其在肿瘤细胞多种亚结构同时超分辨成像中的应用研究,betway官方app 优秀青年科学基金项目，2015.1-2017.12，项目编号：14YQ002 9、靶向生物标记物的双光子荧光染料的构建，精细化工国家重点实验室开放课题基金资助项目，2015.12-2018.3，项目编号：KF1510 10、端基官能化荧光染料的构建及其在生物成像分析中的应用研究，新乡市锦源化工有限公司横向项目，2016.9-2021.8，项目经费：50万 11、DNA荧光探针的构建及其对DNA损伤精准测量与成像的性能研究，河南省高校科技创新人才支持计划，2018.1-2019.12，项目编号：18HASTIT001 代表性成果： <文章> 29.Jun W. Liu, Yong G. Yang, Kui Wang, Ge Wang, Cong C. Shen, Yue H. Chen, Yu F. Liu, Tony D. James, Kai Jiang, andHua Zhang*, Activation and monitoring of mtDNA damage in cancer cells via the “Proton-Triggered” decomposition of an ultrathin nanosheet,ACS Applied Materials & Interfaces, 2021, 13, 3669-3678.(IF=8.758)
28.Yuehua Chen, Yuzhu Wang, Yonggang Yang, Yuhuan Li, Yafu Wang, Ge Wang, Tony D. James*, Xiaopeng Xuan,Hua Zhang* and Yufang Liu, A molecular-logic gate for COX-2 and NAT based on conformational and structural changes: visualizing the progression of liver disease,Chemical Science,2020, 11, 6209–6216.(IF=9.346)
27.Beidou Feng, Kui Wang, Yonggang Yang, Ge Wang,Hua Zhang*, Yufang Liu and Kai Jiang. Ultrasensitive recognition of AP sites in DNA at the single-cell level: one molecular rotor sequentially self-regulated to form multiple different stable conformations,Chemical Science, 2019, 10, 10373–10380.(IF=9.346)
26.Feng Beidou, Wang Kui, Junwei Liu, Guojiang Mao, Jingqiang Cui, Xiaopeng Xuan, Kai Jiang, andHua Zhang*. Ultrasensitive apurinic/apyrimidinic site-specific ratio fluorescent rotor for real-time highly selective evaluation of mtDNA oxidative damage in living cells,Analytical Chemistry.2019,91,13962−13969.(IF=6.785)
25.Tao Jiang, Xin Wang, Ge Wang, Yafu Wang, Kui Wang, Xiaopeng Xuan, Changpo Chen*, Kai Jiang,Hua Zhang*. Light-activated "cycle-reversible intramolecular charge transfer" fluorescent probe: monitoring of pHi trace change induced by UV light in programmed cell death,Chem. Commun.2019, 55,5279-5282.(IF=5.996)
24.Yafu Wang,Ge Wang, Kui Wang, Zaoxia Wang, Yuming Guo,Hua Zhang*. A lysosomes-targeted ratio fluorescent probe for real-time monitoring of micropolarity in cancer cells,Sensors and Actuators B: Chemical.2018,261,210-217.(IF=7.1)
23.JianPing Li, Shuang Xia,Hua Zhang*, GuiRong Qu, HaiMing Guo*, Three-input “AND-Type” fluorescent logic gate as ratio probe for specific imaging of hypochlorite in rough endoplasmic reticulum,Sensors and Actuators B: Chemical.2018,255,622-629.(IF=7.1)
22.Caixia Wang, Ge Wang, Xiang Li, Kui Wang, Jing Fan, Kai Jiang, Yuming Guo,Hua Zhang*. Highly sensitive fluorescence molecular switch for the ratio monitoring of trace change of mitochondrial membrane potential.Analytical Chemistry.2017,89,11514–11519.(IF=6.785)
21.Hua Zhang*, Yafu Wang, Xiaopeng Xuan, Ge Wang, Haiming Guo, Jiangli Fan*. A dynamic invertible intramolecular charge-transfer fluorescence probe: real-time monitoring of mitochondrial ATPase activity.Chem. Commun. 2017,53, 5535-5538.(IF=5.996)
20.Hua Zhang*, Caixia Wang, Kui Wang, Xiaopeng Xuan, Qingzhang Lv, Kai Jiang*. Ultrasensitive fluorescent ratio imaging probe for the detection of glutathione ultratrace change in mitochondria of cancer cells.Biosensors and Bioelectronics. 2016,85,96–102.(IF=10.257)
19.Jianping Li, Yanyan Zhang,Hua Zhang*, Xiaopeng Xuan, Mingsheng Xie, Shuang Xia, Guirong Qu, Haiming Guo*. Nucleoside-based ultrasensitive fluorescent probe for the dual-mode imaging of microviscosity in living cells.Analytical Chemistry. 2016, 88,5554-5560.(IF=6.785)
18.Hua Zhang*,Kui Wang, Xiaopeng Xuan, Qingzhang Lv, Yamin Nie, Haiming Guo*. Cancer cell-targeted two-photon fluorescence probe for the real-time ratiometric imaging of DNA damage.Chem. Commun. 2016,52, 6308-6311.(IF=5.996)
17.Hua Zhang*, Caixia Wang, Ge Wang, Kui Wang, Kai Jiang*. Thrombin-mediated ratiometric two-photon fluorescent probe for selective imaging of endogenous ultratrace glutathione in platelet.Biosensors and Bioelectronics. 2016, 78, 344-350.(IF=10.257)
16.Hua Zhang*, Caixia Wang , Tao Jiang , Haiming Guo* , Ge Wang , Xinhua Cai , Lin Yang , Yi Zhang , Haichuan Yu , Hui Wang , and Kai Jiang . Microtubule-targetable fluorescent probe: site-specific detection and super-resolution imaging of ultratrace tubulin in microtubules of living cancer cells.Analytical Chemistry.2015, 87, 5216-5222. (IF=6.785)
15.Hua Zhang*,Jiangli Fan,Kui Wang,Jing Li,Caixia Wang,Yamin Nie,Tao Jiang,Huiying Mu,Xiaojun Peng,and Kai Jiang.Highly sensitive naphthalene-based two-photon fluorescent probefor in situ real-time bioimaging of ultratrace cyclooxygenase‑2 inliving biosystems.Analytical Chemistry.2014, 86, 9131-9138. (IF=6.785)
14.Hua Zhang, Jiangli Fan, Jingyun Wang, Shuangzhe Zhang, Bairui Dou, and Xiaojun Peng*. An Off–On COX-2-specific fluorescent dye: targeting the Golgi apparatus of cancer cells.J. Am. Chem. Soc.,2013, 135, 11663-11669. (IF=14.612)
13.Hua Zhang, Jiangli Fan, Jingyun Wang, Bairui Dou, Fan Zhou, Jianfang Cao, Junle Qu, Zhi Cao, Weijie Zhao, and and Xiaojun Peng*. Fluorescence discrimination of cancer from inflammation by molecular response to COX- 2 enzymes.J. Am. Chem. Soc.,2013, 135, 17469-17475.(IF=14.612)
12.Hua Zhang, Jiangli Fan, Huijuan Dong, Shuangzhe Zhang, Wenyou Xu, Jingyun Wang, Pan Gao, and Xiaojun Peng*. Fluorene-derived two-photon fluorescent dyes for specific and simultaneous bioimaging of endoplasmic reticulum and lysosomes: group-effect and localization.J. Mater. Chem. B.,2013, 1, 5450-5455.(IF=5.344)
11.Zhiyong Li, Shiguo Sun, Zhigang Yang, Si Zhang,Hua Zhang, Mingming Hu, Jianfang Cao, Jingyun Wang, Fengyu Liu, Fengling Song, Jiangli Fan and Xiaojun Peng*. The use of a near-infrared RNA fluorescent dye with a large Stokes shift for imaging living cells assisted by the macrocyclic molecule CB7.Biomaterials.,2013, 34, 6473-6481.(IF=8.387)
10.Jiangli Fan, Huijuan Dong, Mingming Hu, Jingyun Wang,Hua Zhang, Hao Zhu, Wen Sun and Xiaojun Peng*. Fluorescence imaging lysosomal changes during cell division and apoptosis observed using Nile Blue based near-infrared emission.Chem. Commun.,2014, 50, 882-884. (IF=6.567)
9.Wen Sun, Jiangli Fan, Chong Hu, Jianfang Cao,Hua Zhang, Xiaoqing Xiong, Jingyun Wang, Shuang Cui, Shiguo Sun and Xiaojun Peng*. A two-photon fluorescent dye with near-infrared emission for hydrogen sulfide imaging in biosystems.Chem. Commun.,2013, 49, 3890-3892. (IF=6.567)
8.Liu Fei , Wu Tong, Cao Jianfang,Zhang Hua, Hu Mingming, Sun Shiguo, Song Fengling, Fan Jiangli, Wang Jingyun, Peng Xiaojun*. A novel fluorescent sensor for detection of highly reactive oxygen species, and for imaging such endogenous hROS in the mitochondria of living cells.Analyst.,2013,138,775-778. (IF=4.033)
7. Hu Mingming,Fan Jiangli,Cao Jianfang,Zhang Hua,Sun Shiguo,Peng Xiaojun*. Enhanced fluorescent chemosensor for Ag+in absolute aqueous solution and living cells: An experimental and theoretical study.Analyst.,2012, 137, 2107-2011. (IF=4.033)
6.Zhang Hua, Li Jing, Du Xinzhen, Li Quanmin*. A simple and sensitive assay for ascorbate using potassium ferricyanide as spectroscopic probe reagent.Anal. Biochem.,2009, 388(1):40-46. (IF=2.305) 5.Zhang Hua, Zhang Yan, Wei Xianjun, Du Xinzhen, Li Quanmin*. A novel spectrophotometric methodfor the determination of isoniazid using Cu (II) as spectroscopic probeIon.Chinese. J.Chem.,2009, 27(3):518-522.(IF=0.971) 4.Zhang Hua, Wu Lingli, Li Quanmin*, Du Xinzhen. Determinationofisoniazid among pharmaceutical and the patients’ saliva samples by using potassium ferricyanide as spectroscopicprobereagent.Anal. Chim. Acta.,2008, 628(1):67-72. (IF=4.517) 3.ZhangHua, Wu Lingli, Li Quanmin*, Du Xinzhen. A novel method for the spectrophotometric determination of cefradine by using sodium nitroprusside as chromogenicreagent.Chin.Chem. Lett.,2008, 19(12):1470-1474. (IF=1.21) 2.仉华, 吴伶俐, 李全民, 杜新贞.硝酸钾-硫氰酸铵-水体系萃取浮选铜间接测定甲巯咪唑.分析试验室,2008,27(12):103-106. 1.李晶,仉华, 李全民, 杜新贞.硝酸钾-硫氰酸铵-水体系萃取浮选硫氰酸亚铜间接测定头孢拉定.应用化学,2008,25(9):1095-1100. <专利> 1. Xiaojun Peng,Hua Zhang, Jiangli Fan, Jingyun Wang, Fengling Song, Shiguo Sun. A kind of naphthalene-based two-photon fluorescent dyes, preparation method and application.Europe, America and Japan. International Application Number: PCT/CN2012/071940.(国际专利PCT),European patent No.2778161 2.彭孝军，仉华，樊江莉，王静云，宋锋玲，孙世国，一类以萘为母体的双光子荧光染料、其制备方法及应用，中国，专利号：ZL20121 0055528.X. 3.彭孝军，仉华，樊江莉，王静云，宋锋玲，孙世国，一类以异喹啉酮为母体的双光子荧光染料、其制备方法及应用，中国，专利号：ZL2012 10366760.5. 4.仉华，王彩霞，王魁，蒋涛，王歌，蒋凯，含砜基的双光子荧光染料，中国，专利号：ZL201410664580.4 5.仉华，聂亚敏，蒋涛，王魁，陈粤华，蒋凯，末端官能化的以萘为母体的双光子荧光染料，中国，专利号：ZL201410665513.4. 6.仉华，蒋涛，聂亚敏，陈粤华，王魁，蒋凯,氨基酸类双光子荧光染料,中国，专利号：ZL201410667110.3. 7.仉华、范灵超,杜思雨,吴呈珂,姚美焕,王魁,有机萘与无机磷酸盐的复合纳米材料,中国，专利号：ZL201610257304.5 8.仉华,王亚甫,吴呈珂,陈粤华,郭海明,程定玺，含高能磷酸键的荧光染料，中国，专利号：ZL201610255237.3 9.彭孝軍，ヅャン華，樊江莉，王靜雲，ナフタレンを基本骨骼とすゐ二光子蛍光プ口一づ、その製造方法及びその利用方法，日本，专利号：特许第5997288号 10.仉华,冯北斗，牛慧玉，刘俊维，姚美焕,一种无机有机复合……成像检测中的应用, 中国，专利号：ZL201710682857.X |
