朱博，男，博士，副教授，硕士生导师。

入选博士后创新人才支持计划（2017年）

河南省优秀青年科学基金获得者（2021年入选）

E-mail:zbtiantang@126.com；zhubo2019@htu.edu.cn

教育经历：

2005年9月—2009年7月，河南大学，药学院，理学学士学位

2009年9月—2012年7月，河南大学，药学院，医学硕士学位，导师：江智勇教授、严琳教授

2013年9月—2016年7月，河南大学，化学化工学院，理学博士学位，导师：江智勇教授

工作经历：

2012年8月—2013年8月，漯河医学高等专科学校 辅导员

2017年4月—2019年6月，betway官方app ，化学化工学院，师资博士后，合作导师：常俊标教授

2019年6月—至今，betway官方app ，化学化工学院，副教授

研究领域与兴趣：

1. 不对称催化合成

2. 抗肿瘤、抗抑郁药物合成

近年来主持的主要科研项目：

河南省自然科学基金-优青，2021年，在研，主持

国家自然科学基金（81903465）：手性含氟东莨菪碱类似物的设计、合成及其抗抑郁活性研究，主持。

博士后创新人才支持计划（BX201700071）：药物分子中手性仲醇构建新手段，主持。

博士后面上基金（2017M622348）：构建γ-官能团化非相邻手性仲醇的不对称质子化反应，主持。

代表性论文：

（20）Li, L.;Zhu, B.*; Fan, H.; Jiang, Z.; Chang, J.* Direct organocatalytic asymmetric Michael reaction of fluorine hemiaminal-type nucleophile to 4-nitro-5-styrylisoxazoles.Organic Chemistry Frontiers2020,7, 1343–1348.

（19）Xu, X.; He, Y.; Zhou, J.; Li, X.;Zhu, B.*; Chang, J.*Organocatalytic Asymmetric Michael Addition of Pyrazol-5-ones to β‑Trifluoromethyl-α,β-unsaturated Ketones: Stereocontrolled Construction of Vicinal Quaternary and Tertiary Stereocenters.J. Org. Chem.2020,85, 574−584

（18）Lu, B.; Xin, S.;Zhu, B.*; Chang, J.* Enantioselective Conjugate Addition–Protonation of 5H-Oxazol-4-ones and 5-Methylene 1,3-oxazolidine-2,4-diones: 2,2'-Biphenol-Induced Diastereoselectivity Switch.Chin. J. Chem.2019,37, 689-694. (invited)

（17）Zhu, B.; Lu, B.; Zhang, H.; Xu, X.; Jiang, Z.*; Chang, J.* Phase-Transfer-Catalyzed, Enantioselective Vinylogous Conjugate Addition−Cyclization of Olefinic Azlactones To Access Multifunctionalized Chiral Cyclohexenones.Org. Lett.2019,21,3271-3275.

（16）Chai, G.;Zhu, B.; Chang, J.*Synthesis and Application of Substituted 1,16-Dihydroxytetraphenylenes in Catalytic symmetric Allylboration of Ketones.J. Org. Chem.2019,84, 120–127.

（15）Xia, X.; Zhu, Q.; Wang, J.; Chen, J.; Cao, W.;Zhu, B.*; Wu, X.* Direct Asymmetric Vinylogous Mannich Addition of 3,5-Disubstituted-4-nitroisoxazoles to Isatin-Derived Imines Catalyzed by a Bifunctional Phase-Transfer-Catalyst.J. Org. Chem.2018,83, 14617–14625.

（14）Zhu, B.; Li, F.; Lu, B.; Chang, J.*; Jiang, Z.* Organocatalytic Enantioselective Vinylogous Aldol Reaction of 5-Alkyl-4-Nitroisoxazoles to Paraformaldehyde.J. Org. Chem.2018,83, 11350–11358.

（13）Zhu, B.; Lee, R.; Yin, Y.; Li, F.; Coote, M.*; Jiang, Z.* Enantioselective Vinylogous Amination of 5-Alkyl-4-nitroisoxazoles with a Dipeptide-Based Guanidinium Phase-Transfer Catalyst.Org. Lett.2018,20, 429−432.

（12）Li, S.;Zhu, B.(共一); Lee, R.; Qiao, B.; Jiang, Z.* Visible light-induced selective aerobic oxidative transposition of vinyl halides using a tetrahalogenoferrate(III) complex catalyst.Organic Chemistry Frontiers2018,5, 380−385.

（11）Zhu, B.; Qiu, S.; Li, J.; Coote, M. L.; Lee, R.; Jiang, Z.* Asymmetric [4+2] annulation of 5H-thiazol-4-ones with a chiral dipeptide-based Brønsted base catalyst.Chem. Sci.2016,7, 6060–6067.

（10）Zhu, B.; Lee, R.; Li, J.; Ye, X.; Hong, S.-N.; Qiu, S.; Coote, M. L.; Jiang, Z.*Chemoselective Switch in Asymmetric Organocatalysis of 5H-oxazol-4-ones andN-Itaconimides towards Tandem Conjugate Addition−Protonation or [4+2] Cycloaddition.Angew. Chem. Int. Ed.2016,55, 1299−1303.

（9）Zhu, B.; Zhang, W.; Lee, R.; Han, Z.; Yang, W.; Tan, D.; Huang, K.-W.; Jiang, Z.*Direct Asymmetric Vinylogous Aldol Reaction of Allyl Ketones with Isatins: Divergent Synthesis of 3-Hydroxy-2-Oxindole Derivatives.Angew. Chem. Int. Ed.2013,52, 6666–6670 (Selected as the inside back cover picture of Angewandte Chemie) (Highlighted bySynfacts2013,9, 0784–0784; Contributors: Benjamin List, Mattia Riccardo Monaco).

（8）Zhu, B.; Yan, L.; Pan, Y.; Lee, R.; Liu, H.; Han, Z.; Huang, K.-W.; Tan. C.-H.; Jiang, Z. Lewis Base Catalyzed Enantioselective Allylic Hydroxylation of Morita-Baylis-Hillman Carbonates with Water.J. Org. Chem.2011,76, 68946900.

（14）Zhao, X.;Zhu, B.; Jiang, Z.* Acyclic Amino Acid-Based Bifunctional Chiral Tertiary Amines, Quaternary Ammoniums and Iminophosphoranes as Organocatalysts.Synlett2015,26, 2216−2230. (Invited Account).

（7）Tong, G.;Zhu, B.; Lee, R.; Yang, W.; Tan, D.; Yang, C.; Han, Z.; Yan, L.; Huang, K.-W.; Jiang, Z.* Highly Enantio- and Diastereoselective Allylic Alkylation of Morita-Baylis-Hillman Carbonates with Allyl Ketones.J. Org. Chem.2013,78, 5067–5072.

（6）Qiu, S.; Lee, R.;Zhu, B.; Coote, M. L.; Zhao, X.; Jiang, Z.* Highly Enantio- and Diastereoselective [4 + 2] Cycloaddition of 5Hoxazol-4-ones with NMaleimides.J. Org. Chem.2016,81, 8061−8069.

（5）Yan, L.; Han, Z.;Zhu, B.; Yang, C.; Tan, C.-H.; Jiang, Z.* Asymmetric Alylic Alkylation of Morita-Baylis-Hillman Carbonates withα-Fluoro-β-Keto Esters.Beilstein J. Org. Chem.2013,9, 1853–1857.

（4）Li, J.; Qiu, S.; Ye, X.;Zhu, B.; Liu, H,; Jiang, Z.* Dipeptide-Based Chiral Tertiary Amine-Catalyzed Asymmetric Conjugate Addition Reactions of 5H-Thiazol/Oxazol-4-Ones.J. Org. Chem.2016,81, 11916−11923.

（3）Jiang, Z.; Bai, X.; Chen, W.; Zhang, G.;Zhu, B.; Jiang, Z.* Organocatalytic Enantioselective Vinylogous Aldol Reaction of Allyl Ketones to Activated Acyclic Ketones.Org. Lett.2016,18, 260−263.

（2）Yang, C.; Chen, W.; Yang, W.;Zhu, B.; Yan, L.; Tan, C.-H.; Jiang, Z.* Bicyclic-Guanidine-Catalyzed Asymmetric Michael Addition of 3-Substituted Oxindoles to 2-Cyclopentenone.Chem. Asian J.2013,8, 2960−2964.

（1）Yang, W.; Wei, X.; Pan, Y.; Lee, R.;Zhu, B.; Liu, H.; Yan, L.; Huang, K.-W.; Jiang, Z.;* Tan, C.-H. Highly Enantio- and Diastereoselective Synthesis of β-Methyl-γ- Monofluoromethyl-Substituted Alcohols.Chem. Eur. J.2011,17, 8066−8070. (VIP paper)