鱼类低温应激和损伤的信号通路与调控机制
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摘要:
许多优良水产养殖鱼类不耐低温,冬季冷害常导致大量养殖鱼类死亡和巨大经济损失,严重制约着我国水产养殖业的发展.低温胁迫可导致鱼类在大分子、细胞、组织、器官和系统水平出现严重损伤现象,进而影响鱼体的神经、免疫、心血管等系统功能.鱼体对低温胁迫的响应依赖于细胞内的各种生物学过程和信号传导通路.鱼体细胞内的Ca2+、MAPK、FoxO、自噬等信号通路可感知和传递低温信号,并启动低温应激反应,以增强鱼体的低温耐受能力.同时,低温胁迫也能激活鱼体细胞内的p53、凋亡、坏死等信号通路,促进细胞和鱼体死亡.细胞内存活和死亡信号通路之间的相互作用和动态平衡,决定组织、细胞的损伤程度和鱼体生存.通过重点介绍相关研究的新进展,为深入解析鱼类低温适应分子机制和抗寒育种提供参考.
Many of excellent aquaculture fish species do not tolerate low temperature.Winter chilling injury often leads to the death of a large number of cultured fish and huge economic losses,which is seriously restricting the development of aquaculture in China.Low temperature stress can cause serious damages to fish at the levels of macromolecules,cells,tissues,organs and systems,thereby affecting the functions of nervous,immune,cardiovascular and other systems in fish.The response of fish to low temperature stress depends on various biological processes and signal transduction pathways in cells.Ca2+,MAPK,FoxO,autophagy and other signal pathways in fish cells can sense and transmit the cold signal,and initiate cold stress response to enhance the cold tolerance of fish.Meanwhile,low temperature stress can also activate p53,apoptosis,necrosis and other signal pathways in fish cells,which can promote the death of cell and fish.The interaction and dynamic balance between living and dead signal pathways in cells determine the injury degree of tissues and cells and the fish survival.This overview mainly introduces the novel progress of related researches,and provides a reference for further understanding the molecular mechanisms of cold acclimation and breeding cold-resistant fish.
作者:
崔宗斌 任静 龙勇
Cui Zongbin;Ren Jing;Long Yong(Institute of Microbiology,Guangdong Academy of Sciences,Guangzhou 510070,China;Institute of Hydrobiology,Chinese Academy of Sciences,Wuhan 430072,China)
机构地区广东省科学院微生物研究所 中国科学院水生生物研究所
出处:
《betway官方app 学报:自然科学版》 CAS 北大核心 2023年第3期11-21,共11页
Journal of Henan Normal University(Natural Science Edition)
基金国家自然科学基金(31871463,31772836,31572610).
关键词:
鱼类 低温胁迫 低温耐受 低温适应 信号通路
fish cold stress cold tolerance cold acclimation signal pathways
分类号:
S917.4 [农业科学—水产科学]
