双酚A暴露致神经细胞凋亡和炎症性死亡的研究进展

摘要：

双酚A(BPA)是生产聚碳酸酯和环氧树脂塑料的添加剂,具有内分泌干扰物效应。由于大量研究发现BPA具有神经毒性,其暴露对大脑神经功能及行为变化的影响受到越来越多的关注.研究发现,氧化应激常伴随着BPA诱导的神经细胞凋亡和炎症性死亡(焦亡)反应的发生,导致神经细胞形态和功能改变,是BPA暴露与神经系统疾病相关性的重要连接纽带.研究聚焦BPA暴露诱导神经细胞凋亡和炎症性死亡这一生理现象,对BPA暴露通过线粒体、内质网以及死亡受体通路信号上的细胞凋亡的分子作用机制的详细介绍,探讨了细胞凋亡、细胞焦亡之间的关系以及他们与神经系统疾病的潜在关系,指出BPA暴露诱导的神经细胞凋亡与炎性反应的分子机制尚需要大量的动物、靶向敲除实验以及人群实验加以验证.同时,应关注低剂量BPA暴露参与毒性通路或与其他毒性通路相互作用而加重复合污染物暴露的健康效应,为深入研究BPA暴露的神经毒性机制及其毒性干预提供参考.

Bisphenol A(BPA)is an additive in the plastic production of polycarbonate and epoxy resin with the effects of endocrine disrupting.The effects of BPA exposure on brain neural function and behavior have attracted more and more attention because a large number of studies have shown that BPA has neurotoxicity.Studies have shown that oxidative stress is often accompanied by the BPA-induced nerve cell apoptosis and inflammatory death(pyroptosis),which often leads to the morphological and functional changes of nerve cells.Hence,it is an important link between BPA exposure and nervous system diseases.Therefore,this study focused on the physiological phenomenon of nerve cell apoptosis and inflammatory death induced by BPA exposure,comprehensively reviewing the molecular mechanism of apoptosis through mitochondria,endoplasmic reticulum and death receptor pathway signaling pathway.Their potential relationship with nervous system diseases were also discussed.The molecular mechanism of neuronal apoptosis and inflammatory response induced by BPA exposure still needs to be verified by a large number of targeted knockout animal experiments and population experiments.Besides,attention should be paid to the health effects of low-dose BPA exposure by the involvement in toxic signaling pathways or interaction with other toxic pathways.This review provides a viewpoint for further study on the neurotoxic mechanism and toxic intervention of BPA exposure.

作者：

范瑞芳 王丛丛

Fan Ruifang;Wang Congcong(Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring and Guangdong Provincial Engineering,Technology Research Center for Drug and Food Biological Resources Processing and Comprehensive Utilization,School of Life Sciences,South China Normal University,Guangzhou 530631,China)

机构地区：

华南师范大学广州市亚热带生物多样性与生物监测重点实验室

出处：

《betway官方app 学报：自然科学版》 CAS 北大核心 2022年第1期12-22,共11页

Journal of Henan Normal University(Natural Science Edition)

基金：

国家自然科学基金(21777048)。

关键词：

双酚A 神经毒性 氧化应激 细胞凋亡 炎症性死亡

Bisphenol A neurotoxicity oxidative stress apoptosis inflammatory death

分类号：

R714 [医药卫生—妇产科学]

双酚A暴露致神经细胞凋亡和炎症性死亡的研究进展.pdf