细胞外囊泡来源的miRNA的生物学功能及临床应用
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摘要：
细胞外囊泡(extracosles vesicles,EVs)可分为外泌体、微囊泡和凋亡小体3类.在功能上,EVs可在细胞和组织之间传递核酸(DNA、mRNA和非编码RNA)、蛋白质等.研究发现,作为转录后关键调控基因表达的microRNAs(miRNAs)也存在EVs中.最近的证据显示,EVs来源的miRNAs(EVs miRNAs)在维持正常的体内平衡中起着重要作用.阐述了EVs miRNAs的生理功能,讨论了其在疾病诊断和治疗中的可能应用.
Recently,accumulative attention has been paid to extracellular vesicles(EVs),membrane-enclosed particles,which can be divided into three categories:exosomes,microvesicles and apoptotic bodies.Functionally,EVs can convey nucleic acids(DNA,mRNA and noncoding RNAs),proteins and etc.between cells and tissues.microRNAs(miRNAs),as critically and post-transcriptionally regulating gene expression,have also been found in EVs.Recent evidence has indicated that EVs-derived miRNAs(EVs miRNAs)are critically involved in maintaining normal homeostasis.Herein,we review the physiological functions of EVs miRNAs,and discuss their possible application in the diagnosis and treatment of diverse diseases.
作者：
余国营 韩棕远 王棋文
Yu Guoying;Han Zongyuan;Wang Qiwen(State Key Laboratory Cell Differentiation and Regulation,Henan International Joint Laboratory of Pulmonary Fibrosis,Institute of Biomedical Science,Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis,College of Life Sciences,Overseas Expertise Introduction Center for Discipline Innovation of Pulmonary Fibrosis,Henan Normal University,Xinxiang 453007,China)
机构地区：
betway官方app 河南省与科技部共建细胞分化与调控国家重点实验室
出处：
《betway官方app 学报：自然科学版》 CAS 北大核心 2021年第4期98-105,113,F0002,共10页
基金：
国家重点研发计划“政府间国际科技创新合作”重点专项(2019YFE0119500) 国家肺纤维化生物学过程及防控学科创新引智基地(111计划) 河南省肺纤维化国际联合实验室 河南省肺纤维化过程与防控杰出外籍科学家工作室.
关键词：
细胞外囊泡 MIRNAS 生物学功能 诊断 治疗
extracellular vesicles miRNAs biological function diagnosis therapy
分类号：
R563 [医药卫生—呼吸系统]
