花状碳酸钙的仿生合成及其载药性能

摘要：

生理温度下,以无水氯化钙和碳酸钠为原料,硫酸软骨素为靶向试剂,癌细胞分泌物为形貌调控剂,制得花状碳酸钙.运用场发射扫描电子显微镜(FESEM)、X射线粉末衍射仪(XRD)、傅里叶红外光谱仪(FT-IR)对碳酸钙的形貌和结构成分进行了表征测定.激光共聚焦实验和负载实验证明该碳酸钙可以高效负载抗肿瘤药物盐酸阿霉素(DOX),不同pH值下的释放实验表明,该负载体系的DOX更易在弱酸性条件下释放,并且释放较为缓慢,有较好的缓释性能.细胞活性(MTT)实验表明,该负载体系对肿瘤细胞有特异性抑制效果.

Herein,flower-like calcium carbonate were prepared at physiological temperature using chondroitin sulfate as target agent and cancer cell secretion as regulators of morphology.The morphology,microstructure,and composition of the as-prepared calcium carbonate were characterized by FESEM,XRD and FT-IR.Confocal laser scanning microscopy and loading experiment results showed that the flower-like calcium carbonate can efficiently load the clinical anticancer drug doxorubicin.The drug-release evaluation result showed that the drug-loading system exhibited the better release performance under the weak acidic conditions with sustained manner to specifically and significantly treat cancers.

作者：

朱琳 谢晓晓 杨林

Zhu Lin;Xie Xiaoxiao;Yang Lin(School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China)

机构地区：

betway官方app 化学化工学院

出处：

《betway官方app 学报：自然科学版》 CAS 北大核心 2020年第1期50-55,共6页

基金：

国家自然科学基金(21171051) 河南省创新型科技团队(CXTD2009005).

关键词：

分泌物 花状 碳酸钙 载药 缓释

secretion flower-like calcium carbonate drug-loading sustained release

分类号：

O611.6 [理学—无机化学]

花状碳酸钙的仿生合成及其载药性能.pdf