3,9-苝二甲酸的合成研究
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摘要：
以二氢苊为起始原料,先经氧化反应得到1,8-萘二甲酸酐,通过酰化反应得到1,8-萘亚酰胺,再通过在碱性环境中高温条件下C-C偶联得到3,4,9,10-苝亚酰胺,进而在强酸作用下转化为3,4,9,10-苝四酸二酐,最后在高压釜中碱性水解脱羧得到3,9-苝二甲酸.该方法操作简单,产率较高,适合工业化生产.
Perylene-3,9-dicarboxylic acid is one kind of key intermediate in the field of new material synthesis. Using acenaphthene as starting material, the first intermediate 1,8-naphthalic anhydride was synthesized with oxidation reaction, followed by harvesting the second intermediate 1, 8-naphthylamine by the acylation reaction. 3,4,9,10-perylene acrylamide was then synthesized through C-C coupling under the higher temperature in alkaline solution, which was further transferred to 3,4,9,10-perylene tetranhydride with the action of strong acid. Finally Perylene-3,9-dicarboxylic acid could be obtained by the alkaline hydrolytic decarboxylation in the autoclave. The synthetic method could be used to industrial production with the feature of simple operation and higher yields.
作者：
刘明娣 周应杰
Liu Mingdi;Zhou Yingjie(College of Applied Engineering,Henan University of Science and Technology,Sanmenxia 472000,China;School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China)
机构地区：
河南科技大学应用工程学院 betway官方app 化学化工学院
出处：
《betway官方app 学报：自然科学版》 CAS 北大核心 2019年第4期79-83,共5页
基金：
河南省科技厅科技攻关项目(152102210022)
关键词：
二氢苊 1,8-萘二甲酸酐 3,4,9,10-苝亚酰胺 3,9-苝二甲酸
acenaphthene 1,8-Naphthalic anhydride 3,4,9,10-perylene diimide perylene-3,9-dicarboxylic acid
分类号：
R914.5 [医药卫生—药物化学]
