具核梭杆菌促结直肠癌发生机制研究进展

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摘要:

结直肠癌(Colorectal Cancer,CRC)是最常见的恶性肿瘤之一,研究表明具核梭杆菌( Fusobacterium nucleatum,F. nucleatum )对CRC的发生具有促进作用.促进CRC发生的重要机制有慢性感染形成炎症环境、 F. nucleatum 表面特征性因子和免疫细胞之间相互作用、激活多条信号通路、免疫抑制和免疫逃避.但 F. nucleatum 促进CRC发生的机制尚不完全清楚,通过查阅大量文献对所有已知的机制进行总结,为进一步研究 F. nucleatum 促CRC发生的机制以及CRC的治疗提供资料.此外, F. nucleatum 的特征性因子FadA,Fap2,LPS在CRC的发生过程中起重要作用,靶向这些因子做疫苗或药物将有望治疗CRC.

Colorectal cancer (CRC) is one of the most common malignant tumor. Studies had shown that Fusobacterium nucleatum ( F.nucleatum ) can promote the occurrence of CRC. The most important carcinogenesis mechanisms of F.nucleatum are chronic infection forming an inflammatory environment, interaction of surface characteristic factors of F.nucleatum with immune cells, activate multiple signaling pathways, immune suppression and immune evasion. However, there are some uncertainty carcinogenesis mechanisms about F.nucleatum , but this paper summarizes all the known mechanisms by referring to a large number of literatures, and this providing information for further study. The characteristic factors of F.nucleatum such as FadA, Fap2 and LPS may play an important role in the development of CRC. This molecules may provide new targets, drugs, and strategies for therapeutic intervention.

作者:

王瑞飞 刘金晶 王玲丽 李鹏 刘兴友

Wang Ruifei;Liu Jinjing;Wang Lingli;Li Peng;Liu Xingyou(College of life science,Henan normal university,Xinxiang 453003,China;Biotechnology research center,Xinxiang college,Xinxiang 453003,China;College of life science,Cornell university,New York,NY14853, America)

机构地区:

betway官方app 生命科学学院 新乡学院生物技术研究中心 美国康奈尔大学生命科学学院

出处:

《betway官方app 学报:自然科学版》 CAS 北大核心 2019年第4期99-104,110,共7页

基金:

2016年国家重点研发计划(2016YFD0500702) 河南省现代农业产业技术体系(S2012-06-02) 河南省科技开放合作项目(182106000043)

关键词:

具核梭杆菌 结直肠癌 机制 治疗

fusobacterium nucleatum colorectal cancer mechanism treatment

分类号:

R378.8 [医药卫生—病原生物学] Q963 [生物学—昆虫学]


具核梭杆菌促结直肠癌发生机制研究进展.pdf

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