6-异硫氰基-9-苄基嘌呤的绿色合成
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摘要:
以6-氯嘌呤为原料,9-位经苄基保护后,与硫氰酸银合成6-异硫氰基-9-苄基嘌呤化合物,并对其合成条件进行了优化.以甲苯/水(体积比为2∶1)作为溶剂,在110℃下反应24h,相转移催化剂SDBS(十二烷基苯磺酸钠)为1mol的条件下,6-异硫氰基-9-苄基嘌呤的产率达到最高(92%收率).目标化合物的结构经~1 H NMR(核磁共振氢谱)、13 C NMR(核磁共振碳谱)和HRMS(高分辨质谱)表征,证明合成了目标产物.
The 6-isothiocyanato-9-benzyl-purine was obtained from 6-chloro-9-benzyl purine and silver thiocyanate.The synthetic conditions of 6-isothiocyanato-9-benzyl purine were optimized.6-isothiocyanato-9-benzyl purine had a high yield（92%）when the reaction was carried out in the presence of toluene and H_2 O component solvent which the volume ratio was 2∶1 at 110 ℃for 24 hcatalyzed by 1 mol phase transfer catalyst of sodium dodecyl benzene sulfonate（SDBS）.The structure of the resulting compounds was characterized by ~1 H NMR,^（13） C NMR and HRMS.The results showed that the structure of the target products were consistent with that of the designed compounds.
作者:
刘清玲 王凯凯 吴珊
Liu Qingling;Wang Kaikai;Wu Shan(Department of Chemistry and Chemical Engineering,Xinxiang University,Xinxiang 453000,China)
机构地区:
新乡学院化学化工学院
出处:
《betway官方app 学报：自然科学版》 CAS 北大核心 2018年第5期68-71,102,共5页
基金:
新乡市第一批科技创新发展专项计划(CXGG16032)
关键词:
嘌呤 异硫氰酸酯 相转移催化剂
purine isothiocyanate phase transfer catalyst
分类号:
O621.3 [理学—有机化学]
