无催化的一锅法合成α-酮酰胺的反应研究

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摘要:

介绍了一种以芳基酮酸为原料、无催化剂、以高活性2,2-二氯-1,3-二异丙基咪唑烷-4,5-二酮作为交联剂一锅法合成α-酮酰胺的简便方法.该方法反应条件温和,产率高.在室温下,绝大多数的芳基酮酸和胺反应都能够很好的转化为对应的α-酮酰胺.通过柱层析对粗产物进行纯化以及采用1 H NMR(核磁共振氢谱)和13 C NMR(核磁共振碳谱)对产物结构进行表征.α-酮酰胺类化合物在有机合成上具有很好的潜在应用价值.

A catalyst-free and one-pot synthetic procedure forα-ketoamide fromα-oxocarboxylic acid using high-activity 2,2-dichloro-1,3-diisopropylimidazolidine-4,5-dione as crosslinking agent was reported in this paper.The method has the advantages of mild reaction condition and high yield.Most of theα-oxocarboxylic acids and amines can be successfully converted to their correspondingα-ketoamides at room temperature.The crude product was purified by column chromatography and the product was characterized by 1H NMR(nuclear magnetic resonance hydrogen spectrum)and 13 C NMR(nuclear magnetic resonance carbon spectrum).α-ketoamide compounds have good potential application value in organic synthesis.

作者:

李建辉唐敏陈新孙中亮王博

Li Jianhui;Tang Min;Chen Xin;Sun Zhongliang;Wang Bo(College of Materials and Chemical Engineering,Hainan University,Haikou 570228,China)

机构地区:

海南大学材料与化工学院

出处:

《betway官方app 学报：自然科学版》 CAS 北大核心 2018年第3期68-73,共6页

基金:

国家自然科学基金(21502036 31360105 31660128) 海南省自然科学基金团队研究项目(2016CXTD006) 海南省自然科学基金面上项目(217041)

关键词:

芳基酮酸胺 2,2-二氯-1,3-二异丙基咪唑烷-4,5-二酮 α-酮酰胺

α-oxocarboxylic acid amine 2,2-dichloro-1,3-diisopropylimidazolidine-4,5-dione α-ketoamide