曲克芦丁新工艺合成研究
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摘要：
以甲醇钠作为催化剂,芦丁、环氧乙烷为原料在甲醇中制备曲克芦丁.研究了在不同温度、反应时间及压强条件下对产品纯度和收率的影响.经实验证明,在高压釜内压强0.2 MPa、温度75℃条件下经5h反应,无需精制即可得到外标纯度高达80%的曲克芦丁.
Troxerutin was successfully synthesized in the methanol catalyzed by sodium methoxide using rutin and ethylene oxide as raw materials. The reactions were studied under different temperature, pressure and reaction time, which could be crucial on the pu-rity and yield of the products. After optimization, the reaction, which was carried out under the pressure of 0. 2 MPa for 5 hours at 75°C , could give as high as 80% purity products without further purification.
作者：
姜玉钦 吴凯 毛龙飞 徐桂清 李伟
Jiang Yuqin Wu Kai Mao Longfei Xu Guiqing Li Wei(School of Chemistry and Chemical Engineering,Henan Engineering Research Center of Chiral Hydroxyl Pharmaceutical,Henan Normal University, Xinxiang 453007, Chin)
机构地区：
betway官方app 化学化工学院
出处：
《betway官方app 学报：自然科学版》 CAS 北大核心 2017年第4期67-71,共5页
基金：
河南省杰出青年创新新人才项目(164100510015 174100510025)
关键词：
甲醇钠 芦丁 曲克芦丁 甲醇
sodium methoxide rutin troxerutin methanol
分类号：
R914.5 [医药卫生—药物化学]
