有氧运动改善心肌梗塞大鼠血流动力学异常和自主神经功能紊乱
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摘要：
目的:观察8周有氧运动对心肌梗塞大鼠血流动力学和自主神经功能的影响并探讨其可能机制.方法:27只SD大鼠随机分为假手术组(S组,n=10)、心肌梗塞组(M组,n=9)和心肌梗塞运动组(ME组,n=8),心肌梗塞模型采用冠状动脉结扎术,ME组进行8周跑台训练.末次训练后48h处死动物,分别测定大鼠心脏结构与功能、血流动力学、心率变异性以及心肌神经生长因子(NGF)和酪氨酸羟化酶(TH)基因表达水平.结果:(1)与S组比较,M组大鼠左室扩张、心功能下降,血流动力学异常,心率变异性显示自主神经功能紊乱,心肌NGF和TH mRNA与蛋白表达下调(P<0.05);(2)与M组比较,ME组心功能增强,血流动力学异常和自主神经功能紊乱得以改善,心肌NGF和TH mRNA与蛋白表达上调(P<0.05).结论:长期有氧运动可能通过改善血流动力学异常和自主神经功能紊乱抑制心肌梗塞大鼠心脏重塑并提高心功能.
Objective： To explore the effects of eight weeks aerobic exercise on autonomic nervous function and hemody- namics in myocardial infarction rats and investigate the possible mechanism. Methods： Twenty-seven SD rats were randomly di- vided into sham operation group （S group, n= 10）, myocardial infarction group （M group, n= 9） and myocardial infarction plus exercise group （ME group, n= 8）. Myocardial infarction model was established by coronary artery ligation and animals of ME group performed an eight weeks treadmill running. Forty-eight hours after last training, animals were sacrificed and cardiac structure, cardiac function, hemodynamics, heart rate Variability, gene expression of myocardial nerve growth factor （NGF） and tyrosine hydroxylase （TH） were determined, Results： （1） Compared with S group, left ventricle dilatated, heart function reduced, hemodynamics showed abnormality, heart rate variability displayed autonomic nervous dysfunction and downregula- tion of mRNA and protein of myocardial NGF and TH （P〈0.05） in M group; （2） Compared with M group, heart function enhanced, hemodynamics abnormality and autonomic nervous dysfunction improved, mRNA and protein of myocardial NGF and TH （P〈0.05） upregulated in ME group （P〈0.05）. Conclusion： Long-term aerobic exercise suppressed cardiac remodel- ling and enhanced cardiac function via improving hemodynamic abnormality and autonomic nervous dysfunction in myocardial in- farction rats.
作者：
刘莹
机构地区：
信阳师范学院体育学院
出处：
《betway官方app 学报：自然科学版》 CAS 北大核心 2016年第3期184-188,共5页
基金：
河南省重大科技攻关项目(152102310117)
关键词：
有氧运动 心肌梗塞 大鼠 自主神经 血流动力学
aerobic exercise myocardial knfarction rat autonomic nerve hemodynamics
分类号：
G804.2 [文化科学—运动人体科学]
