急、慢性有氧运动对白介素的影响

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摘要:

目的:观察急、慢性有氧运动后大鼠血液白介素IL-2和IL-6的变化情况,探讨运动后白介素的应答、适应性反应.方法:120只3月龄SD大鼠随机分为急性运动组和四周运动组,跑台速度为25m/min的恒定负荷.各组运动前、运动后即刻和运动后3h取血,采用放射免疫法检测大鼠血液中IL-2和IL-6的变化情况.结果:1、一次急性运动后,与安静对照组相比,IL-6的浓度在运动后即刻、运动后3h均出现升高的趋势,但没有统计学意义(P>0.05).IL-2浓度的变化与IL-6相似,运动后即刻有所下降,3h后虽有回升,但无统计学意义(P>0.05).2、4周有氧耐力运动对白介素的影响:1周有氧耐力训练后,WK1-B,WK1-A,WK1-3h与C组相比,大鼠血液中IL-6的浓度显著升高,差异非常显著(P<0.01).WK1-3h组与WK1-B组相比,IL-2的浓度有明显升高(P<0.05),而与WK1-A组相比,有非常显著性差异(P<0.01).有氧耐力运动两周后,WK2-B,WK2-A和WK2-3h组大鼠的IL-6水平与C组有显著的升高(P<0.05).两周的有氧耐力使IL-2浓度在WK2-B组较C组有明显的升高现象,差异非常显著(P<0.01).WK2-A组与C组相比,IL-2浓度变化不明显(P>0.05).WK2-3h组与WK2-B组相比,IL-2浓度有显著升高(P<0.05)第三周和第四周大鼠IL-2和IL-6的浓度变化不明显,与安静对照组相比,没有显著性差异(P>0.05).结论:一次性有氧运动对大鼠白介素的影响不明显,白介素在急性运动后的变化情况与运动强度大小可能有关.周期性有氧耐力训练促进大鼠机体产生良好的适应性,白介素呈升高-下降的变化趋势,1-2周是免疫应激阶段,3-4周大鼠机体实现了良好的免疫调节,处于适应阶段.

The aim of this study was to observe the changes of interleukin 6 （IL-6） and IL-2 in rat plasma after an acute exercise and four weeks aerobic training and probed into the stress response and adaption of interleukin after an acute exercise and periodic training. Methods.. One hundred and twenty rats （three months old） were enrolled into training program and were divided randomly into acute exercise groups and 4 weeks chronic aerobic training groups. Blood samples were obtained before, after 3 hours post-training. The plasma concentrations of IL-2 and IL-6 were measured by radioimmunoassay （RIA）. Results： 1. After an acute aerobic exercise, the concentration of IL-6 elevated at any post-exercise group compared to control group, but no significance in differences was observed （P^0. 05）. The similar to IL-2. The concentration change of IL-2 increased imme- diately after exercise while went down after 3 hour recovery, but no statistical significance observed （P〈0. 05）. 2. The chan- ges of IL-2 and IL-6 after four weeks were observed as follows： After 1 week training, comparing with group C, their levels of IL-6 of WK1-B, WK1-A and WKI-3 h was significantly elevated and had very significant differences （P〈0.01）. The IL-2 lev- el in WK1-3 h group significantly increased （P〈0.05） comparing with the WK1-B, and significant difference observed compa- ring with WK1-A group （P〈0.01）. After 2 weeks training, their levels of IL-6 of WK2-B, WK2-A and WK2-3 h group obvi- ously elevated comparing with C group （P〈0. 05） ,and the IL-2 level of WK2-B increased significantly comparing with C group （P〈0.01）, but no difference observed in WK2-A group comparing with C group （P〉0.05）. IL-2 concentration reach a high- er level in WK2-3 h group compared with WK2-B group （P〈0.05）. In the third and fourth week, the levels of IL-2 and IL-6 didn＇t change significantly in all groups comparing with C groups （P〉0.05）. Conclusion： An acute aerobic exercise had no obvious effect on interleukin level of rat. Exercise intensity may be a very important relevant factor. Cyclical aerobic endurance training promoted rat＇s body produce good adaptability, the change of interleukin had a ＂rise to down＂ tendency. The rats body was in immune stress stage in the first two weeks and in the third to fourth week stay in adjustment stage.

作者:

刘海超张蕾

机构地区:

郑州大学体育系

出处:

《betway官方app 学报：自然科学版》 CAS 北大核心 2015年第5期131-136,共6页

基金:

国家社科基金青年项目(13CTY024) 2013年河南省科技厅重点科技攻关项目862激光中频治疗法在高水平篮球运动员运动损伤治疗中的应用(132102310437)

关键词:

有氧运动免疫系统白介素6(IL-6) 白介素2(IL-2)

aerobic exercise immune system interleukin-6 （IL-6） interleukin-2 （IL-2）

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