P-gp,MRP,LRP和GST-π等多药耐药蛋白在肝癌中的协同表达研究

摘要:

目的:探讨多药耐药相关标志物P-gp,MRP,LRP和GST-π在肝癌细胞中的共表达情况.方法:以69例肝癌患者为本次研究对象,应用免疫组化SP法检测多药耐药相关标志物P-gp,MRP,LRP和GST-π在肝癌组织的共表达情况.结果:不同分型、不同分期肝癌组织P-gp,MRP,LRP和GST-π阳性表达率及共表达差异无显著性(P>0.05);分化程度不同的肝癌组织多药耐药相关标志物P-gp,MRP,LRP和GST-π阳性表达率及共表达有明显差异(P<0.05).结论:多药耐药相关标志物P-gp,MRP,LRP和GST-π在不同分型、不同分期和不同分化程度的肝癌组织中均有明显共表达,在不同分化程度的肝癌组织中阳性表达率及共表达更为明显.

Objective：To investigate the co-expressions of multidrug resistance related markers P-gp,MRP,LRP,and GST-πin hepatocellular carcinoma.Methods：We adopted SP method to detect the expression levels of P-gp,MRP,LRP,and GST-πin 69 cases of hepatocarcinoma tissue.Results：Positive expression rates and co-expressions of P-gp,MRP,LRP and GST-πwere no significant difference in the different type and the different TNM of hepatocellular carcinoma（P〉 0.05）.However,in the different degrees of differentiation of hepatocellular carcinoma,there were significant difference both positive expression rates and co-expressions of P-gp,MRP,LRP and GST-π（P〈0.05）.Conclusion：Multidrug resistance related markers of P-gp,MRP,LRP,and GST-πhad significant expression in different types,different stages,and different degrees of hepatocellular carcinoma.What’s more,these expressions had coordination.Positive expression rates and co-expression of P-gp,MRP,LRP,and GST-πwas more apparent in different degrees of differentiation of hepatocellular carcinoma.

作者:

王雷 王煜霞 陈丽平 薛会朝 原志庆

机构地区:

新乡医学院第一附属医院普外科 新乡医学院基础医学院

出处:

《betway官方app 学报：自然科学版》 CAS 北大核心 2015年第4期134-137,共4页

基金:

河南省基础与前沿技术研究计划项目(13A320854)

关键词:

P-GP MRP LRP GST-Π 肝癌

P-gp MRP LRP GST-π hepatocellular carcinoma

分类号:

Q485 [生物学—生理学]

P-gp,MRP,LRP和GST-π等多药耐药蛋白在肝癌中的协同表达研究.pdf