长期摄入水解单宁对鼠类生殖的影响

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摘要：

水解单宁(hydrolyzed tannin)是橡子内主要的单宁酸类型,对以橡子为主要食物来源的鼠类的生存繁衍有重要影响.为探究长期取食水解单宁对鼠类的生殖激素与生殖器官产生的影响.选择72只(雌雄个体各36只)4周龄的健康昆明小鼠,随机分为4组,分别为对照组(水解单宁比例为0)、低单宁组(水解单宁比例为2%)、中单宁组(水解单宁比例为7%)和高单宁组(水解单宁比例为12%),用不同水解单宁含量的饲料饲喂42d后解剖取样.结果显示,高含量水解单宁显著降低了雄鼠存活率;中、高含量水解单宁对生殖激素的稳定产生负面效应;高含量水解单宁造成生殖器官损伤,导致小鼠卵巢与睾丸生理结构改变,降低了正常卵泡数量和精子的发生.试验验证了长期摄入高含量水解单宁打破了鼠类的生殖激素平衡且造成了生殖器官的损伤.

Hydrolyzed tannin,the predominant type of tannic acid in acorns,has a significant impact on the survival and reproduction of rodents that primarily feed on acorns.The aim of this experiment was to explore the impact of long-term hydrolyzed tannin consumption on the reproductive hormones and reproductive organs of rodents.72 four-week-old healthy Kunming mice(36 males and 36 females)and randomly divided them into four groups:control group(with 0%hydrolyzable tannin content),low-tannin group(with 2%hydrolyzable tannin content),medium-tannin group(with 7%hydrolyzable tannin content),and high-tannin group(with 12%hydrolyzable tannin content).After being fed with different levels of hydrolyzable tannin-containing diets for 42 days,the mice were dissected for sampling.The results showed that:High levels of hydrolyzed tannin significantly reduced the survival rate of male mice.Moderate to high levels of hydrolyzed tannin had a negative impact on the stable production of reproductive hormones.High levels of hydrolyzed tannin caused damage to the reproductive organs,leading to changes in the physiological structure of the ovaries and testes in mice,and a reduction in the number of normal follicles and spermatogenesis.The experiment confirmed that long-term intake of high levels of hydrolyzed tannins disrupted the hormonal balance of rodents and caused damage to their reproductive organs.

作者：

于飞李佳鑫

Yu Fei;Li Jiaxin(College of Life Sciences,Henan Normal University,Xinxiang 453007,China)

机构地区：

betway官方app 生命科学学院

出处：

《betway官方app 学报（自然科学版）》 CAS 北大核心 2024年第3期131-138,共8页

Journal of Henan Normal University(Natural Science Edition)

基金：

国家自然科学基金(U1904105) 河南省高校科技创新人才项目(22HASTIT033).

关键词：

精子质量昆明小鼠水解单宁生殖毒性生殖激素