窦房结节律调控的动力学机制综述

摘要：

窦房结是包埋在右心房的一小片可以自发电位搬荡的组织，是整个心脏搏动的发起点。其节律失常会诱发一系列的综合征，窦房结节律的发起和调控,是心脏电生理和医学在窦房结研究领域的关注点。随着近儿十年来非线性动力学被引人心律失常领域，心脏疾病与物理学的结合研究为这一医学范畴的问题带来了重要的理论发展旨在综述从非线性动力学的角度研究窦房结节律所取得的一些重要成果，比较详细地介绍实房结数值模型、节律调控的分岔机制、信号传导条件，心率变异等方面的研究进展，从目前的发展趋势来看，非线性动力学有可能成为一个有效解释窦房结节律调控的理论框架，因此，建议在多尺度建模和基于多尺度模型进行基础动力学理论分析方面做进一步的研究工作。

Sinoatrial node(SAN) is a piece of tissue embedded in the right atrium, which is the pacemaker of the whole heart. The abnormal rhythm of SAN may cause diverse arrhythmias. The central focus of SAN in physiology and medicine are the pacemaking initiation and regulation, As nonlinear dynamics was introduced into the research of arrhythmias, in the past few decades the interdisciplinary subjeet of cardiovascular physics has brought about great progresses for such medical prob-lems. The aim of the present paper is to review the relevant advances of $AN rhythm regulation obtained by nonlinear dynam-ics, in which the numerical modeling of SAN, the bifurcation mechanisms of heart rate regulation, the conditions of signal propagation, and heart rate variability are discussed. From the developmental trend, we find that nonlinear dynamics may be-come an elfecive theoretical framework for SAN, 'Therefore, we suggest further investigations in multi-seale modeling and the associated dymamical theories in the future.

作者：

黄晓东，汪瑞

Huang Xiaodong，Wang Rui

机构地区：

华南理工大学物理与光电学院

引用本文：

黄晓东，汪瑞，窦房结节律调控的动力学机制综述[J].betway官方app 学报(自然科学版),2024,52(6):97-106

( Huang Xiaodong, Wang Rui. A review on the dynamical mechanisms of rhythmic regulation of sinoatrial nod[1].Journal of Henan Normal University(Natural Seience Edition),2024,52(6):97-106.D01:10.16366/j.cnki1000-2367.2023.12.04.0003.)

基金：

国家自然科学基金；广东省自然科学基金

关键词：

生物物理；非线性动力学；窦房结；数值模拟

biological physics；nonlinear dynamics；sinoatrial node:；numerical simulation

分类号：

O415

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