Function and application of lactate and monocarboxylate transporter protein MCT4 in tissue fibrosis and tumor

摘要:

乳酸及其转运体单羧酸转运蛋白(MCTs)在多种疾病的发生发展过程中承担着非常重要的作用.肿瘤细胞通过Warburg effect产生乳酸不仅可以为其增殖、迁移、侵袭提供能量来源,还可以促进血管生成,帮助肿瘤细胞免疫逃逸.而MCTs承担着乳酸转运的职能,在维持肿瘤细胞代谢共生和代谢适应以及恶性表型方面发挥着必不可少的作用.通过综述乳酸和MCTs的一个亚型MCT4在癌症及癌症相关的疾病中研究进展,以便探讨乳酸和MCT4在疾病发生发展中的作用,同时寻求靶向乳酸及MCT4在疾病治疗的策略.

Lactate and its transporter monocarboxylate transporters(MCTs)play a significant role in the occurrence and development of a variety of diseases.The production of lactate by tumor cells through the Warburg effect can not only provide an energy source for their proliferation,migration and invasion,but also promote angiogenesis and immune escape of tumor cells.MCTs,with the function of lactate transport,play an essential role in maintaining metabolic symbiosis and metabolic adaptation as well as malignant phenotype of tumor cells.Therefore,this article reviews the research progress of lactate and MCT4,a subtype of MCTs,in cancer and cancer-related diseases,in order to explore the role of lactate and MCT4 in the occurrence and development of diseases,and seek disease treatment strategies targeting lactate and MCT4.

作者:

余国营 姬志华 温洪智 孙志恒

Yu Guoying;Ji Zhihua;Wen Hongzhi;Sun Zhiheng(College of Life Sciences,State Key Laboratory of Cell Differentiation and Regulation,Henan International Joint Laboratory of Pulmonary Fibrosis,Henan Normal University,Xinxiang 453007,China)

机构地区betway官方app 生命科学学院

出处:

《betway官方app 学报:自然科学版》 CAS 北大核心 2023年第3期1-10,共10页

Journal of Henan Normal University(Natural Science Edition)

基金国家重点研发计划“政府间国际科技创新合作”重点专项(2019YFE00119500) 国家自然科学基金(32200714).

关键词:

乳酸 MCT4 肿瘤 纤维化

lactate MCT4 tumor fibrosis

分类号:

R392.12 [医药卫生—免疫学]

乳酸及单羧酸转运蛋白MCT4在组织纤维化和肿瘤中的作用及应用.pdf