Advances in glymphatic system and related brain diseases

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摘要:

胶质淋巴系统是近年新发现的中枢淋巴系统.它由动脉周隙、星形胶质细胞终足、神经组织间质和静脉周隙4部分组成.最新研究表明,胶质淋巴系统在脑组织废物清除方面发挥着至关重要的作用,胶质淋巴系统异常是阿尔兹海默症、创伤性脑损伤、脑出血和偏头痛等脑疾病发展的共同特征,修复胶质淋巴系统为相关疾病治疗带来了新曙光.综述了胶质淋巴系统的微细结构、正常脑淋巴的来源及其通过胶质淋巴系统的流动路径和各种疾病发展过程中胶质淋巴系统的障碍情况及机制,期望为深入理解脑代谢废物清除机制和探索新的脑疾病治疗方法提供参考资料和科学思路.

Glymphatic system is a newly discovered central lymphatic system,which is composed of artery space,astrocyte endfoot,interstitial fluid and vein space.The latest research shows that glymphatic system plays a crucial role in the clearance of waste from brain tissue.Abnormalities in glymphatic system are common features in the development of Alzheimer's disease,traumatic brain injury,cerebral hemorrhage and migraine.Repair of glymphatic system offers a new hope for the treatment of brain-related diseases.With an expection to provide reference and scientific ideas for understanding the clearance mechanism of brain waste and exploring new treatment methods of brain diseases,this paper reviews the microstructures of glymphatic system,the origin of normal cerebral lymph and its flow path through glymphatic system,as well as the barrier mechanism of glymphatic system in the development of various diseases.

作者:

唐超智张玉玲

Tang Chaozhi;Zhang Yuling(College of Life Sciences,Henan Normal University,Xinxiang 453007,China)

机构地区:

betway官方app 生命科学学院

出处:

《betway官方app 学报：自然科学版》 CAS 北大核心 2021年第1期87-92,共6页

基金:

国家自然科学基金(81974321) 河南省科技攻关计划(212102310836) 新乡市科技攻关计划(GG2019002 GG2019003).

关键词:

胶质淋巴系统阿尔兹海默症创伤性脑损伤脑出血偏头痛

glymphatic Alzheimer's disease traumatic brain injury cerebral hemorrhage migraine