Protein expression relationship and clinical significance of lipid metabolism-related genes of PPARγ2,SCD1 and VEGF in hepatocellular-carcinoma

摘要:

近年来研究发现肿瘤组织有脂代谢异常,但脂代谢异常在肿瘤发生发展中的作用还不清楚.为了探讨脂代谢异常在肿瘤中的作用,本研究对45例肝细胞肝癌患者,用免疫组化方法研究其癌组织中硬脂酰辅酶A去饱和酶1(SCD1)、过氧化物酶体增殖物激活受体γ2(PPARγ2)、血管内皮生长因子(VEGF)的表达情况,并结合ishak评分和患者的病理检查结果,分析和探讨PPARγ2,SCD1及VEGF在肝细胞癌组织中的表达与肿瘤发生发展的关系、它们相互之间的表达相关性及临床意义.本研究发现在肝细胞癌组织中,PPARγ2,SCD1及VEGF在肿瘤组织中高表达,其高表达率分别为40.00%、46.70%、75.50%.相关性分析发现SCD1和VEGF之间存在相关性(r=0.482,p≤0.001),但是PPARγ2和SCD1(r=0.221,p=0.164),以及PPARγ2与VEGF(r=0.219,p=0.169)之间不存在相关性.该研究提示脂代谢相关基因与血管生成相关,但不通过PPARγ2调控SCD1途径;脂代谢相关基因SCD1是抑制血管生成和肿瘤发展的潜在靶点.

Some studies have found that abnormal lipid metabolism is often observed in tumor tissue, but it is unclear about the role of abnormal lipid metabolism in tumorigenesis and development. To explore the role of abnormal lipid metabolism in tumorigenesis and development, we determined the expression of stearoyl-CoA desaturase 1(SCD1), peroxisome proliferator activated receptorγ2(PPARγ2), and vascular endothelial growth factor(VEGF) by immunohistochemistry in 45 cases of hepatocellular carcinoma tissues. Combined with the ishak score and pathological examination, we investigated the relationship between the expression of PPARγ2, SCD1 and VEGF in hepatocellular carcinoma, and their relationship to tumorigenesis and clinical significance. In this study, we found that PPARγ2, SCD1 and VEGF were highly expressed in hepatocellular carcinoma tissues, and their rate of high expression was 40.00%, 46.70% and 75.50% respectively. Correlation analysis revealed a correlation between SCD1 and VEGF(r=0.482,p≤0.001), but there was no correlation between PPARγ2 and SCD1(r=0.221,p=0.164) and PPARγ2 and VEGF(r=0.219,p=0.169). This study suggests that lipid metabolism-related gene SCD1 is associated with angiogenesis, but SCD1 was not regulated by PPARγ2 in hepatocellular carcinoma. SCD1 may be a potential target for inhibiting angiogenesis and tumor development.

作者:

苏改改 刘红丽 孙永健 彭战 李一鸣 席守民 沈国民

Su Gaigai;Liu Hongli;Sun Yongjian;Peng Zhan;Li Yiming;Xi Shoumin;Shen Guomin(College of Medicine,Henan University of Science and Technology,Luoyang 471023,China)

机构地区:

河南科技大学医学院

出处:

《betway官方app 学报：自然科学版》 CAS 北大核心 2020年第2期100-104,共5页

基金:

国家自然科学基金青年基金(31301076)。

关键词:

肝细胞肝癌 过氧化物酶体增殖物激活受体γ2(PPARγ2) 血管内皮生长因子(VEGF) 硬脂酰辅酶A去饱和酶1(SCD1)

hepatocellular carcinoma peroxisome proliferator activated receptor γ2(PPARγ2) vascular endothelial growth factor(VEGF) stearoyl-CoAdesaturase 1(SCD1)

分类号:

R735.1 [医药卫生—肿瘤]

脂代谢相关基因PPARγ2和SCD1与血管内皮生长因子VEGF在肝细胞癌组织的蛋白表达相关性及临床意义.pdf