The cellular and molecular mechanism for planarians head regeneration
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摘要:
涡虫因其拥有非凡的再生能力,成为实验室再生研究的一种常见模式动物.涡虫身体被切割后残存的任意部分都能再生出缺失组织,即使是小到虫体1/279的片段也能够在很短时间内再生出一个完整的个体,其中头部再生的研究更是备受关注.涡虫头部再生不仅是普通的组织再生,还包括一个功能完整的中枢神经系统再生.本文主要综述了涡虫头部再生的最新研究进展,阐明了涡虫在身体中线区域通过构建新的组织中心-前极,引导干细胞迁移,完成头部再生的细胞和分子机制.同时详细介绍了涡虫体内全能干细胞和功能干细胞的区别及它们分别在再生过程中的作用.
The planarian has a powerful regenerative capability,and is an organism that is able to regenerate a new individual from a tiny fragment of its own body,no matter that the minimum fragment size is as small as 1/279th of a planarian.The planarian species can regenerate a head de novo including a functional brain and central nervous system.Here,the latest advances of planarian head regenerative are reviewed.New findings indicate after decapitation,planarians build an organizing center-anterior pole from stem cells at the old midline that directs head patterning and outgrowth.A stem cell population(neoblasts)generates new cells and is comprised of pluripotent stem cells(cNeoblasts)and fate-specified cells.Their mechanism was also introduced in planarian regeneration.
作者:
康静 陈广文
Kang Jing;Chen Guangwen(College of Life Science,Henan Normal University,Xinxiang 453007,China;College of Life Science,Xinxiang Medical University,Xinxiang 453003,China)
机构地区:
betway官方app 生命科学学院 新乡医学院生命科学技术学院
出处:
《betway官方app 学报：自然科学版》 CAS 北大核心 2020年第1期75-81,共7页
基金:
国家自然科学基金(31471965,31570376,31570357,u1604173) 河南省科技攻关项目(161202210404).
关键词:
涡虫 头部再生 前极 干细胞 分子机制
planarian head regeneration anterior pole stem cell cellular and molecular mechanism
分类号:
Q959 [生物学—动物学]
