Progress in the treatment of osteoarthritis with mesenchymal stem cells

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摘要:

骨关节炎(Osteoarthritis,OA)是最常见的骨科疾病.传统的治疗方法包括非手术法和手术法,但在恢复骨关节炎软骨的正常结构与机能方面并不理想.因此,急需建立新的高效的治疗骨关节炎的方法.以干细胞疗法为研究方向的再生医学为关节软骨的修复提供了新的治疗方向.对可用于治疗骨关节炎的间充质干细胞(Mesenchymal Stem Cells,MSCs)的来源、作用机理和治疗方法的研究进展进行了阐述.

Osteoarthritis(OA)is the most common orthopaedic disease.Traditional therapeutic methods including non-surgical and surgical methods are not ideal in restoring the normal structure and function of articular cartilage in osteoarthritis.Therefore,it is necessary to establish new and effective methods for the therapy of osteoarthritis.Regenerative medicine represented by stem cell therapy provides a novel treatment direction for the repair of articular cartilage.In this paper,the origin,mechanism and application of mesenchymal stem cells(MSCs)in osteoarthritis treatment are reviewed.

作者:

王文晟孔冰洁唐超智张东芳贾璐昕赵茁然

Wang Wensheng;Kong Bingjie;Tang Chaozhi;Zhang Dongfang;Jia Luxin;Zhao Zhuoran(College of Life Science,Henan Normal University,Xinxiang 453007,China)

机构地区:

betway官方app 生命科学学院

出处:

《betway官方app 学报：自然科学版》 CAS 北大核心 2019年第6期82-88,2,共7页

基金:

国家自然科学基金(81974321)

关键词:

骨关节炎间充质干细胞关节软骨再生免疫调节

osteoarthritis mesenchymal stem cells articular cartilage regeneration immunomodulation