朱功名

发布时间:2023-11-07浏览次数:233

朱功名,男,博士,讲师,药理学支部书记

联系方式:zhugm1201@163.com






教育经历:

20079-20116月  betway官方app   生命科学学院

20119-20176月  兰州大学    生命科学学院  硕博连读  博士


工作经历:

20177-20187月  中山大学 特聘副研究员  药物化学研究

20189-20235月  betway官方app   化学化工学院

20235-至今     betway官方app   抗病毒性传染病创新药物全国重点实验室


研究领域与兴趣:

1.核苷药物设计合成及筛选

2.多肽药物的定向合成及关键技术的开发

3.活性多肽后修饰及其化学生物学研究

4.核酸及多肽化学生物学研究


近年来主持的主要科研项目:

1.国家自然科学青年基金,2019-2021年,主持,资助金额:27.5万元。

2.广东省自然科学基金,2018-2021年,主持,资助金额:10万元。

3.博士后基金面上项目一等资助,2018-2020年,主持,资助金额:8万元。

4.betway官方app 博士启动经费,2019-2021年,主持,资助金额:8万。

5.参与完成国家自然科学青年基金2项,其中一项被评为优秀;

6.参与重点项目一项,面上项目两项。


代表性论文:

(1).Gongming Zhu#, Guangjun Bao#, Yiping Li, Wangsheng Sun,* Jing Li, Liang Hong,* and Rui Wang*. Efficient Catalytic Kinetic Resolution of Spiro-epoxyoxindoles with Concomitant Asymmetric Friedel-Crafts Alkylation of Indoles.Angew. Chem. Int. Ed.2017,56, 5332 –5335.

(2).Wangsheng Sun#,Gongming Zhu#, Chongyang Wu, Guofeng Li, Liang Hong,* and Rui Wang*. Organocatalytic Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Azlactones and Methyleneindolinones.Angew. Chem. Int. Ed.2013,52, 8633–8637.

(3).Gongming Zhu#, Yiping Li#, Guangjun Bao, Wangsheng Sun,* Liwu Huang, Liang Hong,* and Rui Wang*.Catalytic Kinetic Resolution of Spiro-Epoxyoxindoleswith 1 Naphthols: Switchable Asymmetric Tandem Dearomatization/Oxa-Michael Reaction and Friedel−Crafts Alkylation of 1 Naphthols at the C4 Position.ACS Catal.2018,8, 1810−1816.

(4).Gongming Zhu, Guangjun Bao, Yiping Li, Junxian Yang, Wangsheng Sun, Jing Li, Liang Hong,* and Rui Wang*. Chiral Phosphoric Acid Catalyzed Asymmetric Oxidative Dearomatization of Naphthols with Quinones.Org. Lett.,2016,18, 5288-5291.

(5).Gongming Zhu, Junxian Yang, Guangjun Bao, Ming Zhang, Jing Li, Yiping Li, Wangsheng Sun,* Liang Hong,* and Rui Wang*. Catalyst-controlled switch of regioselectivity in the asymmetric allylic alkylation of oxazolones with MBHCsChem. Commun.2016,52, 7882-7885.

(6).Gongming Zhu, Wangsheng Sun, Chongyang Wu, Guofeng Li, Liang Hong,* and Rui Wang*. Base-Catalyzed Diastereoselective [3 + 3] Annulation of 3-Isothiocyanatooxindoles and Azomethine Imines.Org. Lett.2013,15, 4988.

(7).Jiaojiao Shen,Gongming Zhu, Yanbo You, Bianbian Huo, Fangyin Dai, Honglei Wang, Anlian Zhu and Lingjun Li. Designing a Light-Induced Glycosylation Reaction for Poststage Synthesis of ADP-2″-Deoxyribosyl Derivatives.Org. Lett.2023,21, 3961-3966.

(8).Mengqi Wang, Luyao Li, Shuping Yang, Fangyuan Guo, Gongming Zhu*, Bo Zhu*, Junbiao Chang*. Synthesis of novel oxazol-5-one derivatives containing chiral trifluoromethyl and isoxazole moieties as potent antitumor agents and the mechanism investigation.Bioorganic Chemistry.2023,135, 106505.

(9). Yuan-Yang Guo, Rujie Zhang, Bianbian Huo, Luying Wang, Donghe Yuan, Jingsi Bai, Honglei Wang,Gongming Zhu, Xiguang Zhang, Anlian Zhu, Tingjian Chen and Lingjun Li*. Site-specific unnatural base excision via visible light.Chem. Commun.2022,58, 11717-11720.

(10). Anlian Zhu; Xin Li; Lili Bai;Gongming Zhu;Yuanyang Guo; Jianwei Lin; Yiwen Cui; GaofeiTian; Lihe Zhang; Jianji Wang; Xiang David Li; Lingjun Li ; Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides,Nat. Commun., 2020, 11: 5600.


Baidu
map