朱功名,男,博士,讲师,药理学支部书记
联系方式:zhugm1201@163.com
教育经历:
2007年9月-2011年6月 betway官方app 生命科学学院
2011年9月-2017年6月 兰州大学 生命科学学院 硕博连读 博士
工作经历:
2017年7月-2018年7月 中山大学 特聘副研究员 药物化学研究
2018年9月-2023年5月 betway官方app 化学化工学院
2023年5月-至今 betway官方app 抗病毒性传染病创新药物全国重点实验室
研究领域与兴趣:
1.核苷药物设计合成及筛选
2.多肽药物的定向合成及关键技术的开发
3.活性多肽后修饰及其化学生物学研究
4.核酸及多肽化学生物学研究
近年来主持的主要科研项目:
1.国家自然科学青年基金,2019-2021年,主持,资助金额:27.5万元。
2.广东省自然科学基金,2018-2021年,主持,资助金额:10万元。
3.博士后基金面上项目一等资助,2018-2020年,主持,资助金额:8万元。
4.betway官方app 博士启动经费,2019-2021年,主持,资助金额:8万。
5.参与完成国家自然科学青年基金2项,其中一项被评为优秀;
6.参与重点项目一项,面上项目两项。
代表性论文:
(1).Gongming Zhu#, Guangjun Bao#, Yiping Li, Wangsheng Sun,* Jing Li, Liang Hong,* and Rui Wang*. Efficient Catalytic Kinetic Resolution of Spiro-epoxyoxindoles with Concomitant Asymmetric Friedel-Crafts Alkylation of Indoles.Angew. Chem. Int. Ed.2017,56, 5332 –5335.
(2).Wangsheng Sun#,Gongming Zhu#, Chongyang Wu, Guofeng Li, Liang Hong,* and Rui Wang*. Organocatalytic Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Azlactones and Methyleneindolinones.Angew. Chem. Int. Ed.2013,52, 8633–8637.
(3).Gongming Zhu#, Yiping Li#, Guangjun Bao, Wangsheng Sun,* Liwu Huang, Liang Hong,* and Rui Wang*.Catalytic Kinetic Resolution of Spiro-Epoxyoxindoleswith 1 Naphthols: Switchable Asymmetric Tandem Dearomatization/Oxa-Michael Reaction and Friedel−Crafts Alkylation of 1 Naphthols at the C4 Position.ACS Catal.2018,8, 1810−1816.
(4).Gongming Zhu, Guangjun Bao, Yiping Li, Junxian Yang, Wangsheng Sun, Jing Li, Liang Hong,* and Rui Wang*. Chiral Phosphoric Acid Catalyzed Asymmetric Oxidative Dearomatization of Naphthols with Quinones.Org. Lett.,2016,18, 5288-5291.
(5).Gongming Zhu, Junxian Yang, Guangjun Bao, Ming Zhang, Jing Li, Yiping Li, Wangsheng Sun,* Liang Hong,* and Rui Wang*. Catalyst-controlled switch of regioselectivity in the asymmetric allylic alkylation of oxazolones with MBHCs,Chem. Commun.2016,52, 7882-7885.
(6).Gongming Zhu, Wangsheng Sun, Chongyang Wu, Guofeng Li, Liang Hong,* and Rui Wang*. Base-Catalyzed Diastereoselective [3 + 3] Annulation of 3-Isothiocyanatooxindoles and Azomethine Imines.Org. Lett.2013,15, 4988.
(7).Jiaojiao Shen,Gongming Zhu, Yanbo You, Bianbian Huo, Fangyin Dai, Honglei Wang, Anlian Zhu and Lingjun Li. Designing a Light-Induced Glycosylation Reaction for Poststage Synthesis of ADP-2″-Deoxyribosyl Derivatives.Org. Lett.2023,21, 3961-3966.
(8).Mengqi Wang, Luyao Li, Shuping Yang, Fangyuan Guo, Gongming Zhu*, Bo Zhu*, Junbiao Chang*. Synthesis of novel oxazol-5-one derivatives containing chiral trifluoromethyl and isoxazole moieties as potent antitumor agents and the mechanism investigation.Bioorganic Chemistry.2023,135, 106505.
(9). Yuan-Yang Guo, Rujie Zhang, Bianbian Huo, Luying Wang, Donghe Yuan, Jingsi Bai, Honglei Wang,Gongming Zhu, Xiguang Zhang, Anlian Zhu, Tingjian Chen and Lingjun Li*. Site-specific unnatural base excision via visible light.Chem. Commun.2022,58, 11717-11720.
(10). Anlian Zhu; Xin Li; Lili Bai;Gongming Zhu;Yuanyang Guo; Jianwei Lin; Yiwen Cui; GaofeiTian; Lihe Zhang; Jianji Wang; Xiang David Li; Lingjun Li ; Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides,Nat. Commun., 2020, 11: 5600.