白大昌，博士，副教授，硕士生导师
邮箱地址：baidachang@126.com;baidachang@htu.edu.cn.
教育经历：
2005.09 - 2009.07 郑州大学 化学专业 理学学士
2009.09 - 2014.07 中国科学院上海有机化学研究所 有机化学专业 理学博士（硕博连读） 导师：侯雪龙 研究员
工作经历：
2014.07 - 2015.08 中科院上海有机所金属有机国家重点实验室 助理研究员
2015.10–2016.10美国内布拉斯加医学研究中心 博士后
2016.11-2020.04 betway官方app 讲师
2020.04-至今 betway官方app 副教授
研究领域与兴趣：
1.发展以绿色合成化学为导向的新反应方法和技术，研究过渡金属（镍，铜，钯等）催化惰性化学键的不对称催化转化体系以及功能有机氟化合物的合成
2.将发展的方法学以及具有潜在生物活性的有机小分子化合物应用到抗病毒药物的研发中
近年来主持的主要科研项目：
1.国家自然科学基金-青年项目，铜催化肟酯与缺电子烯烃的环加成反应，2019-2021,26万
2.河南省优秀青年科学基金，过渡金属催化不对称C-C/C-O键活化反应研，2020-2023,25万元
获奖情况：
2020年“Thieme Chemistry Journal Award”国际学术期刊奖
2020年河南省优秀青年基金
代表性论文：
(1).Bai, Da-Chang.*;Wu, Fen.; Chang, Ling-Na.;Wang, Man-Man.; Wu, Hao.; Chang, Jun-Biao.*Highly Regio- and Enantioselective Hydrosilylation ofgem-Difluoroalkenes by Nickel Catalysis.Angew. Chem. Int. Ed.2022,61, e202114918. (IF = 15.336, Highlight bySynfacts2022, 18, 0398)
(2).Bai, Da-Chang.*;Yu, Yan-Jiang.; Guo, Hai-Ming.; Chang, Jun-Biao.; Li, Xing-Wei.* Nickel(0)-Catalyzed Enantioselective [3+2] Annulation of Cyclopropenones anda,b-Unsaturated Ketones/Imines.Angew. Chem. Int. Ed.2020,59, 2740-2744. (IF = 12.257, Highlight bySynfacts2020.16.641)
(3).Bai, Da-Chang.; Wang, Xue-Li.; Zheng, Guang-Fan.; Li, Xing-Wei.* Redox-Divergent Synthesis of Fluoroalkylated Pyridines and 2-Pyridones through Cu-Catalyzed N-O Cleavage of Oxime Acetates.Angew. Chem. Int. Ed.2018,57, 6633-6637.(IF =12.257)
(4).Bai, Da-Chang.(#); Xia, Jin-Tao.(#); Song, Fang-Fang .; Li, Xue-Yan .; Liu, Bing-Xian.; Liu, Li-Hong.; Zheng, Guang-Fan.; Yang, Xi-Fa.; Sun, Jia-Qiong, * Li, Xing-Wei.* Rhodium(III)-catalyzed diverse [4 + 1] annulation of arenes with 1,3-enynes via sp3/sp2C–H activation and 1,4-rhodium migration.Chem. Sci.2019,10. 3987-3993. (#: co-first authors, IF = 9.556)
(5).Bai,Da-Chang.*;Xu, Teng.;Ma, Chao-Rui.;Zheng, Xin.;Liu, Bing-Xian.;Xie, Fang.;Li, Xing-Wei.* Rh(III)-Catalyzed Mild Coupling of Nitrones and Azomethine Imines with Alkylidenecyclopropanes via C−H Activation: Facile Access to Bridged Cycles.ACS Catal.2018,8, 4194-4200.(IF = 11.384)
(6).Bai, Da-Chang.; Yu, Fei-Le.; Wang, Wan-Ying.; Chen, Di.; Li, Hao.; Liu, Qing-Rong.; Ding, Chang-Hua.; Chen, Bo.*; Hou, Xue-Long.* Palladium/N-heterocyclic carbene catalysed region and diastereoselective reaction of ketones with allyl reagents via inner-sphere mechanism.Nature Communications2016,7,11806-11817. (IF = 12.353)
(7). Yu, Fei-Le.(#);Bai, Da-Chang.(#); Liu, Xiu-Yan.(#); Jiang, Yang-Jie.; Ding, Chang-Hua.*; Hou, Xue-Long.* Pd-Catalyzed Allylic Alkylation of gem-Alkyl, Aryl-Disubstituted Allyl Reagents with Ketones: Diastereoselective Construction of Vicinal Tertiary and Quaternary Carbon Centers.ACS Catal.2018, 8, 3317–3321.(#: co-first authors, IF = 11.384)
(8). Wu, Fen.; Li, Xin.; Chang, Junbiao.;Bai, Dachang *Palladium-catalyzed multi components oxy-aminofluorination and aminofluorination ofgem-difluoroalkenes.Chin Chem Lett.2023.doi:10.1016/j.cclet.2023.109155
(9).Bai, Da-Chang.*;Guo, Yuanyuan.; Ma, Dandan.; Guo, Xiuli.; Wu, Hao. Copper-Catalyzed Hydroamination ofgem-Difluoroalkenes Access to Diversified α Difluoromethyl Amines.Org. Lett.2023,25, 533-537.
(10).Chen, Junyan.;Bai, Da-Chang.;*Guo,Xiuli.; Wang, Yiyao.;Li, Xingwei.*Diastereodivergent[4+2] Annulation of Biphenylenes with EnonesviaNickel(0)-catalyzed C-C bond Activation.Chin Chem Lett.2022.33, 5056-5060.
(11).Bai, Da-Chang.;*Liu, Song.; Chen, Jun-Yan.; Yu, Yan-Jiang.; Wang, Man-Man.; Chang, Jun-Biao.; Lan., Yu.;* Li, Xing-Wei.* Mechanistic studies on nickel-catalyzed enantioselective [3 + 2] annulation for γ-butenolide synthesis via C–C activation of diarylcyclopropenones.Org. Chem. Front.,2021,8, 3023-3031.
(12).Bai, Da-Chang.;* Chen, Jun-Yan.; Zheng, Bing-Bing.; Li, Xue-Yan.; Chang, Jun-Biao*.Catalytic [3+3] Annulation of β-Ketoethers and Cyclopropenones via C(sp3)-O/C-C Bond Cleavage under Transition-Metal Free Conditions.Chin. J. Chem.2021,39, 2769-2773.
(13). Cui, Yixin.;Bai, Da-Chang.;* Liu,Bingxian.;Chang, Junbiao.;*Li, Xingwei.* Rh(III)-Catalyzed Acylation of Heteroarenes with Cyclobutenones via C–H/C–C Bond Activation.Chem. Commun.,2020,56, 15631-15634.
(14). Xu, Gui-Qing.; Chen, Qi.; Wu, Fen.;Bai, Da-Chang.;*Chang, Jun-Biao.;* Li, Xing-Wei.* Rh(III)-Catalyzed Chemodivergent Coupling of N Phenoxyacetamides and Alkylidenecyclopropanes via C−H Activation.Org. Lett.2021,23, 2927−2932.15.
(15). Cui, Yixin.;Bai, Da-Chang.;* Liu,Bingxian.;Chang, Junbiao.;*Li, Xingwei.* Rh(III)-Catalyzed Acylation of Heteroarenes with Cyclobutenones via C–H/C–C Bond Activation.Chem. Commun.,2020,56, 15631-15634.
(16). Li, Xue-Yan.; Yu, Yan-Jiang.; Qi, Ruo-Bing.;Bai, Da-Chang*.Facile access to fluoroalkylated 2-aminopyridines by Cu-catalyzed [3 + 3] couplings of oxime esters with β-CF3 acrylonitrile.Tetrahedron Lett.2020.61, 151858-151861.
(17).Cheng, Ruo-Shi.;Bai, Da-Chang.*Enantiodivergent Relay Coupling for Nickel-Catalyzed Stereoselective Functionalization of Cyclopropylzinc Reagents.Chin. J. Org. Chem.2021,41, 1746-1748.
(18). Dai, Hong-Xue.; Wu, Fen.;Bai, Da-Chang*. Recent Advances in Ni-Catalyzed C-C bond Activation Reactions.Chin. J. Org. Chem.2020.40. 1423-1436.