夏晓华

    主讲本科生《遗传学》、《基因工程》和研究生《生物反应器工程》、《基因工程技术》、《模式鱼类遗传学》等课程，并指导多项大学生创新训练项目及大学生生命科学竞赛。主要从事水生动物免疫、动物性别分化及调控和水生生物生理生态等方面的研究。先后在SCI及核心以上期刊发表论文四十余篇，主持国家自然科学基金、科技厅项目、横向合作项目等。

主要研究方向：

1. 水生生物免疫机制研究；

2. 水生生物性别决定和分化；

3.水生生物生态毒理学。

中国遗传学会会员

中国动物学会会员

1. 两种泥鳅DMRT1基因不同选择性剪接体的结构、功能及调控机制（31200923），国家自然科学基金项目，2013-2015，主持；

2. NF-κB信号通路影响黄河鲤性腺分化机制的研究（31972773），国家自然科学基金面上项目，2020-2023，参与；

3. 云南大学横向合作项目，2024-2025，主持；

4. 鱼类特有TLRs识别病原体的分子机制及在生殖细胞中的功能研究，河南省自然科学基金面上培育项目，2022.01-2023.12，主持；

5. 黄河鲤Toll样受体22病原配体的鉴定及在免疫佐剂中的应用，河南省重点科技攻关项目，2021.01-2022.12，主持；

6. 大鳞副泥鳅DMRT1基因不同选择性剪接体的表达模式分析，河南省教育厅项目，2012-2014，主持；

7. TLRs识别病原体的分子机制及在生殖细胞中的功能研究，betway官方app 面上培育项目2021.01-2023.12，主持；

8. 两种泥鳅DMRT1基因不同选择性剪接体的克隆和表达模式分析，天津市细胞遗传与分子调控重点实验室开放基金项目，2012-2014，主持。

代表性论文：

1. Xiaohua Xia*, Ning Liang, Xiaoyu Ma, Lu Qin, Zhongjie Chang, Xiaowen Zhang*. Effect of dietary supplementation with Leuconostoc mesenteroides DH onthe antimicrobial capacity and overall health of juvenile loach (Misgurnus anguillicaudatus)[J].Aquaculture, 2024, 579: 740208.

2. Xiaohua Xia, Xiaoyu Ma, Ning Liang, Lu Qin, Weiran Huo, Yi Li*. Damageof polyethylene microplastics on the intestine multilayer barrier, blood cellimmune function and the repair effect of Leuconostoc mesenteroides DH in thelarge-scale loach (Paramisgurnus dabryanus)[J]. Fish and Shellffsh Immunology. 2024, 147: 109460.

3. Weiran Huo, Lu Qin, Wanwan Guo, Xiaowen Zhang, Qiyan Du, Xiaohua Xia*(通讯作者).PvMR1, a novel C-type lectin plays a crucial role in the antibacterial immune response of Paciffc white shrimp, Penaeus vannamei[J]. Fish and Shellffsh Immunology,2024, 145: 109346.

4. Liuen Wang, Meimei Zheng, Jisheng Liu, Zeyu Jin, Cui Wang, Miaomiao Gao, HongweiZhang, Xiaowen Zhang, Xiaohua Xia*(通讯作者). LDL acontaining C-type lectin mediates phagocytosis of V.anguillarum andregulates immune effector genes in shrimp[J].Fish and Shellffsh Immunology, 2024, 145: 109361.

5. Yi Li, Mengyuan Qin, Shuo Han, Yuqi Wang, Chao Gao, Wenfang Niu, Xiaohua Xia*(通讯作者).Elimination of Microcystis aeruginosa through Leuconostoc mesenteroides DH andits underlying mechanism[J].2024, Science of the Total Environment, 908: 168290.

6. Yi Li, Shuo Han, Yuqi Wang, Mengyuan Qin, Chengjin Lu, Yingke Ma, Wenqing Yang, Jiajia Liu, Xiaohua Xia*(通讯作者), Hailei Wang*.Autoinducer-2 promotes adherence of Aeromonas veronii through facilitating the expression of MSHA type IV pili genes mediated by c-di-GMP[J]. Appl Environ Microbiol. 2023,89(11): e0081923.

7. Xiaowen Zhang, Manli Shen, Cui Wang, Miaomiao Gao, Liuen Wang, Zeyu Jin, Xiaohua Xia*(通讯作者). Impact of aluminum exposure onoxidative stress, intestinal changes and immune responses in red swamp crayfish(Procambarus clarkii)[J].2023, Science of the Total Environment, 855: 158902.

8. Xiaohua Xia, Wanwan Guo, Xiaoyu Ma, Ning Liang, Xiangyu Duan, Peihan Zhang, Ying Zhang, Zhongjie Chang, Xiaowen Zhang*. Reproductive toxicity andcross-generational effect of polyethylene microplastics in Paramisgurnus dabryanus[J].Chemosphere,2023, 313: 137440.

9. Xiaohua Xia,Xiaoyu Ma, Ning Liang, Xiangyu Duan, Songyun Wang, Wanwan Guo, Zhongjie Chang*.QNZ exposure induces development toxicity and mechanisms of hatching inhibition in large-scale loach (Paramisgurnus dabryanus) embryos[J]. Ecotoxicology and Environmental Safety, 2023, 253: 114663.

10. Xiaowen Zhang, Zeyu Jin, Manli Shen,Zhongjie Chang, Guoying Yu, Lan Wang, XiaohuaXia*(通讯作者). Accumulation of polyethylene microplastics induces oxidative stress, microbiome dysbiosis and immunoregulation in crayfish[J].Fish and Shellfish Immunology, 2022, 125: 276-284.

11. Xiaohua Xia, Gaopeng Liu, Xiaoling Wu, Shuangshuang Cui, CongHui Yang, Qi-yan Du, Xiao-wen Zhang. Effects of Macleaya cordata extract on TLR20 and the proinflammatory cytokines in acute spleen injury of loach (Misgurnus anguillicaudatus) against Aeromonas hydrophila infection[J]. Aquaculture,2021, 544(299):737105.

12. Qingyu Sun, Wanwan Guo, Peijin Wang. Zhongjie Chang, Xiaohua Xia*(通讯作者), Qiyan Du. Toxicity of 2-methyl-4-chlorophenoxy aceticacid alone and in combination with cyhalofop-butyl to cyprinus carpio embryos[J]. Environmental Toxicology and Pharmacology, 2021, 87: 103697.

13. Xiaohua Xia,Menghan Sun, Miao Zhou, Zhongjie Chang, Li Li. Polyvinyl chloride microplastics induce growth inhibition and oxidative stress in Cyprinus carpio var.larvae[J]. Scienceof the Total Environment, 2020, 716: 136479.

14. XiaoWen Zhang, CongHui Yang, HongQuan Zhang, XinTong Pan, ZeYu Jin, HongWei Zhang, XiaoHua Xia*(通讯作者). A C-typelectin with antibacterial activity in weather loach, Misgurnus anguillicaudatus[J].Journal of Fish Diseases, 2020, 43(12): 1531–1539.

15. Peijin Wang, Ruyan Wan, Weiran Huo, Hui Dong, Zhongjie Chang, Xiaohua Xia*(通讯作者). Cytotoxicity, genotoxicity,oxidative stress, and apoptosis in HepG2 cells induced by the imidazole ionic liquid 1-dodecyl-3-methylimidazolium chloride[J]. Environmental Toxicology, 2020, 35(6): 665-672.

16. Peijin Wang, Qingyu Sun, Ruyan Wan, Qiyan Du, Xiaohua Xia*(通讯作者).Progesterone affects the transcription of genes in the circadian rhythm signaling and hypothalamic-pituitary-gonadal axes and changes the sex ratio incrucian carp (Carassius auratus)[J].Environmental Toxicology and Pharmacology, 2020, 77: 103378.

17. Xiaohua Xia,Peijin Wang, Ruyan Wan, Zhongjie Chang, Qiyan Du. Progesterone affects sexdifferentiation and alters transcriptional of genes along circadian rhythm signaling and hypothalamic-pituitary-gonadal axes in juvenile Yellow River Carp(Cyprinus carpio var.)[J].Environmental Toxicology, 2019, 34: 1255–1262.

18. Weiran Huo, Ruyan Wan, Peijin Wang, Linxia Zhang，Xiaohua Xia*(通讯作者),Molecular cloning, characterization of dax1 gene and its response toprogesterone in Misgurnus anguillicaudatus, Drug and Chemical Toxicology, 2019, 42: 6, 624-633.

19. Xiaohua Xia, Ruyan Wan,Peijin Wang, Weiran Huo, Hui Dong, Qiyan Du.Toxicity of imidazoles ionicliquid [C16mim]Cl to Hela cells[J]. Ecotoxicology and Environmental Safety, 2018, 162: 408–414.

20. Ruyan Wan, Xiaohua Xia*(通讯作者), Peijin Wang, Weiran Huo, HuiDong, Zhongjie Chang. Toxicity ofimidazoles ionic liquid [C16mim]Cl to HepG2 cells[J]. Toxicology in Vitro, 2018, 52: 1–7.

21. Xiaohua Xia, Peijin Wang,Ruyan Wan, Weiran Huo, Zhongjie Chang. Toxic effects of cyhalofop-butyl onembryos of the Yellow River Carp (Cyprinus carpio var.): Alters embryoshatching, development failure, mortality of embryos and apoptosis[J].Environmental science and pollution research. 2018, 25: 24305–24315.

22. Xiaohua Xia, Weiran Huo, Ruyan Wan, Peijin Wang, Linxia Zhang, Zhongjie Chang. Molecular cloning, characterization, and expression profiles of the Sox3 gene in Chinese loach Paramisgurnus dabryanus[J]. Evolution & Development, 2018, 20: 108-118.

23. Xiaohua Xia, Weiran Huo, Ruyan Wan, Peijin Wang, Zhongjie Chang. Cloning,characterization and function analysis of DAX1 in Chinese loach(Paramisgurnus dabryanus)[J]. Genetica, 2018,146: 487–496.

24. Xiaohua Xia,Ruyan Wan, Weiran Huo, Linxia Zhang, Xiaopei Xia, Zhongjie Chang. Molecular cloning and mRNA expression pattern of Sox4 in Misgurnus anguillicaudatus[J].Journalof genetics, 2018, 97(4): 869–877.

著作:

1.《遗传学实验》，第二版，科学出版社，国家级精品课程配套教材，副主编；

2.《基因工程》，第二版，科学出版社，参编；

3. 河南省《基因工程在线精品课程》，主讲。

专利:

1. 李祎；王海磊；夏晓华，一种利用黑曲霉去除水体中微塑料的方法，中国，CN202110426976.5。

奖励：

1. 河南省自然科学优秀学术论文一等奖；

2. betway官方app 青年骨干教师；

3. betway官方app 研究生优秀指导教师；

4. 全国大学生生命科学竞赛一等奖指导教师；

5. 河南省大学生生命科学竞赛一等奖优秀指导教师。