主讲本科生《普通遗传学》、《基因工程》和研究生《生物反应器工程》、《基因工程技术》、《模式鱼类遗传学》等课程。主要从事动物性别调控、水产动物免疫和环境毒理等研究。先后在SCI及核心以上期刊发表论文四十余篇，主持国家自然科学基金、科技厅项目、横向合作项目和校级项目等。

1.动物性别决定和分化；

2.水生环境毒理学；

3.动物免疫机制研究。

中国遗传学会会员

中国动物学会会员

1、两种泥鳅DMRT1基因不同选择性剪接体的结构、功能及调控机制（31200923），国家自然科学基金项目，2013-2015，主持

2、鱼类特有TLRs识别病原体的分子机制及在生殖细胞中的功能研究，河南省自然科学基金面上培育项目，2022.01-2023.12，主持

3、TLRs识别病原体的分子机制及在生殖细胞中的功能研究，betway官方app 面上培育项目2021.01-2023.12，主持

4、黄河鲤Toll样受体22病原配体的鉴定及在免疫佐剂中的应用，河南省重点科技攻关项目，2021.01-2022.12，主持

5.大鳞副泥鳅DMRT1基因不同选择性剪接体的表达模式分析（12B180011），河南省教育厅项目，2012-2014，主持

6.两种泥鳅DMRT1基因不同选择性剪接体的克隆和表达模式分析，天津市细胞遗传与分子调控重点实验室开放基金项目，2012-2014，主持

7.泥鳅DMRT1基因不同剪接体的克隆和时空表达模式分析，betway官方app 博士科研启动费支持课题，2012-2014，主持

8.大鳞副泥鳅DMRT1基因5′侧翼区的克隆及核心启动子活性分析，betway官方app 青年科学基金项目，2012-2015，主持

代表性论文：

1.Xiaohua Xia, Wanwan Guo, Xiaoyu Ma, Ning Liang, Xiangyu Duan, PeihanZhang, Ying Zhang, Zhongjie Chang, Xiaowen Zhang *. Reproductive toxicity and cross-generational effect of polyethylene microplastics inParamisgurnus dabryanus[J].Chemosphere,2023, 313:137440.

2.Xiaohua Xia, Xiaoyu Ma, Ning Liang, Xiangyu Duan, Songyun Wang, Wanwan Guo, Zhongjie Chang*. QNZ exposure induces development toxicity and mechanisms of hatching inhibition in large-scale loach (Paramisgurnus dabryanus)embryos[J]. Ecotoxicology and Environmental Safety, 2023, 253:114663.

3.Xiaohua Xia, Gaopeng Liu, Xiaoling Wu, Shuangshuang Cui, CongHui Yang, Qi-yan Du,Xiao-wen Zhang. Effects of Macleaya cordata extract on TLR20 and the proinflammatory cytokines in acute spleen injury of loach (Misgurnus anguillicaudatus) against Aeromonas hydrophila infection[J]. Aquaculture,2021, 544(299):737105.

4. Qingyu Sun, Wanwan Guo, Peijin Wang. Zhongjie Chang,Xiaohua Xia(通讯作者), Qiyan Du. Toxicity of 2-methyl-4-chlorophenoxy acetic acid alone and in combination with cyhalofop-butyl to cyprinus carpio embryos[J]. Environmental Toxicology and Pharmacology, 2021, 87:103697.

5.Xiaohua Xia,Menghan Sun, Miao Zhou, Zhongjie Chang, Li Li. Polyvinyl chloride microplastics induce growth inhibition and oxidative stress in Cyprinus carpio var.larvae. Science of the Total Environment, 2020, 716:136479.

6. XiaoWen Zhang, CongHui Yang, HongQuan Zhang, XinTong Pan, ZeYu Jin, HongWei Zhang,XiaoHua Xia(通讯作者).A C-type lectin with antibacterial activity in weather loach,Misgurnus anguillicaudatus. Journal of Fish Diseases, 2020, 43(12):1531–1539.

7. Peijin Wang, Ruyan Wan, Weiran Huo, Hui Dong, Zhongjie Chang,Xiaohua Xia(通讯作者).Cytotoxicity, genotoxicity, oxidative stress, and apoptosis in HepG2 cells induced by the imidazole ionic liquid 1-dodecyl-3-methylimidazolium chloride.Environmental Toxicology, 2020, 35(6):665-672.

8. Peijin Wang, Qingyu Sun, Ruyan Wan, Qiyan Du,Xiaohua Xia(通讯作者).Progesterone affects the transcription of genes in the circadian rhythm signaling and hypothalamic-pituitary-gonadal axes and changes the sex ratio incrucian carp (Carassius auratus). Environmental Toxicology and Pharmacology, 2020, 77:103378.

9.Xiaohua Xia,Peijin Wang, Ruyan Wan, Zhongjie Chang, Qiyan Du. Progesterone affects sex differentiation and alters transcriptional of genes along circadian rhythm signaling and hypothalamic-pituitary-gonadal axes in juvenile Yellow River Carp(Cyprinus carpiovar.). Environmental Toxicology, 2019, 34:1255–1262.

10. Weiran Huo, Ruyan Wan, Peijin Wang, Linxia Zhang，Xiaohua Xia(通讯作者), Molecular cloning, characterization of dax1 gene and its response to progesterone inMisgurnus anguillicaudatus,Drug and Chemical Toxicology, 2019, 42:6, 624-633.

11.Xiaohua Xia, Ruyan Wan,Peijin Wang, Weiran Huo, Hui Dong, Qiyan Du. Toxicity of imidazoles ionicliquid [C16mim]Cl to Hela cells. Ecotoxicology and Environmental Safety, 2018,162:408–414.

12. Ruyan Wan,Xiaohua Xia*(通讯作者), Peijin Wang, Weiran Huo, Hui Dong, Zhongjie Chang. Toxicity of imidazoles ionic liquid[C16mim]Cl to HepG2 cells. Toxicology in Vitro, 2018,52: 1–7.

13.Xiaohua Xia, Peijin Wang,Ruyan Wan, Weiran Huo, Zhongjie Chang. Toxic effects of cyhalofop-butyl onembryos of the YellowRiver Carp (Cyprinus carpio var.): Alters embryoshatching, development failure, mortality of embryos and apoptosis.Environmental science and pollution research. 2018, 25:24305–24315.

14.Xiaohua Xia, Weiran Huo, Ruyan Wan, Peijin Wang, Linxia Zhang, Zhongjie Chang. Molecular cloning, characterization, and expression profiles of the Sox3 gene in Chinese loachParamisgurnus dabryanus.Evolution & Development, 2018, 20:108-118.

15.Xiaohua Xia, Weiran Huo, Ruyan Wan, Peijin Wang, Zhongjie Chang. Cloning, characterization and function analysis of DAX1 in Chinese loach(Paramisgurnus dabryanus). Genetica, 2018, 146:487–496

16.Xiaohua Xia,Ruyan Wan, Weiran Huo, Linxia Zhang, Xiaopei Xia, Zhongjie Chang. Molecular cloning and mRNA expression pattern of Sox4 inMisgurnus anguillicaudatus. Journal of genetics, 2018,97（4）:869–877.

17.Xiaohua Xia, Weiran Huo,Ruyan Wan, Linxia Zhang, Xiaopei xia, Zhongjie Chang. Molecular cloning and expression analysis of Sox3 during gonad and embryonic development inMisgurnus anguillicaudatus.International Journal of Developmental Biology, 2017, 61:565-570.

18. Xiaohua Xia,Ruyan Wan, Weiran Huo, LinxiaZhang, Xiaopei Xia, Zhongjie Chang. Molecular cloning and mRNA expression pattern of Sox4 inParamisgurnus dabryanus. Gene Expression Patterns,2017, 25-26:109–117.

19.Xiaohua Xia,Weiran Huo, Ruyan Wan, Xiaopeixia, Qiyan Du, Zhongjie Chang*. Identification of housekeeping genes as references for quantitative real-time RT-PCR analysisinMisgurnus anguillicaudatus. Journal of Genetics, 2017, 96(6):895-904.

20.Xiaohua Xia, Xiaopei Xia, Weiran Huo, HuiDong, Linxia Zhang,Zhongjie Chang. Toxic effects of imidacloprid on adult loach (Misgurnus anguillicaudatus).Environmental Toxicology and Pharmacology, 2016, 45:132–139.

21.Xiaohua Xia, Jianjun Chen, Linxia Zhang,Qiyan Du, Jinsheng Sun, Zhongjie Chang. Molecular cloning and mRNA expression pattern of Sox10 inParamisgurnus dabryanus. Molecular Biology Reports,2013, 40(4):3123-3134.

22.Xiaohua Xia, Ping Nan, Linxia Zhang,Jinsheng Sun, Zhongjie Chang. Homologue of Sox10 inMisgurnus anguillicaudatus: Sequence, expression pattern duringearly embryogenesis.Fish Physiology and Biochemistry, 2013, 39:1341–1351.

23.Xiaohua Xia, Jie Zhao, Qiyan Du, Zhongjie Chang. Isolation and expression of two distinct Sox8 genes in mudloach (Misgurnus anguillicaudatus). Biochemical Genetics, 2011, 49(3-4):161-176.

著作

1、《遗传学实验》，第二版，科学出版社，国家级精品课程配套教材，副主编

2、《基因工程》，第二版，科学出版社，参编

专利

1、一种细菌发酵用多功能水浴锅支撑推车，受理，2023年