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陈广文

发布时间：2022-03-07






姓名：陈广文

职称：二级教授 博士生导师

办公电话：0373-3325999

电子邮箱：Chengw0183@sina.com








个人简介：

   兰州大学博士，博士生导师，二级教授，国务院政府特殊津贴专家，教育部生物科学类专业教学指导委员会委员，教育部“国培计划”首席专家，教育部本科教学审核评估专家、教育部师范专业认证专家、教育部学位与研究生教育发展中心（教育部学位中心）同行评议专家，全国科学技术名词审定委员会委员，国家自然科学基金同行评议专家。全国模范教师，首届全国教育硕士优秀教师，首届河南省教学名师，中国动物学会第二届青年科技奖获得者，河南省学术与技术带头人，河南省优秀青年科技专家，河南省高等教育教学工作先进个人。中国大百科全书、中国物种红色名录特邀编委等。

   主持淡水涡虫国家自然科学基金面上项目5项，国家科技部重点项目专题、教育部高等学校博士点基金、教育部教师教育改革项目、河南省重大公益项目、河南省杰出青年基金、河南省高校创新人才基金等20余项；在SCI源期刊等发表学术论文80余篇；主持获得国家教学成果二等奖2项，国家精品课程、国家教学团队、国家教师教育实验教学示范中心、国家虚拟仿真实验教学项目等国家质量工程项目4项。获教育部自然科学二等奖、河南省科技进步三等奖、河南省教学成果特等奖等9项；获国家发明专利1项；在科学出版社、高等教育出版社、中国大百科全书出版社等出版著作教材6部。主讲《普通动物学》、《中国淡水涡虫》、《高级动物学》等本科生、硕士生和博士生课程。

研究领域：

    1986年开始从事无脊椎动物学的教学和科学研究工作，1997年开始从事中国淡水涡虫研究。主要研究方向：“中国淡水涡虫资源保护利用以及涡虫再生分子机理”。

主要学术及社会兼职：

  中国动物学会副理事长，中国进出口生物安全学会副会长，国际生物科学联合会中国全国委员会（China National Committee for International Union of Biological Sciences，CCIUBS）委员，中国生态学会动物生态专业委员会委员，全国高等学校教学研究会理事，河南省动物学省级重点学科开放实验室主任，省、部共建细胞分化调控国家重点实验室副主任。

主持或参加科研项目情况：

1.主持国家自然科学基金面上项目《秦岭山脉淡水三肠目涡虫分类和区系研究》；

2.主持国家自然科学基金面上项目《云贵高原淡水涡虫生态学及进化生物学研究》；

3.主持国家自然科学基金面上项目《横断山区淡水涡虫生态学及进化生物学研究》；

4.主持国家自然科学基金面上项目《横断山区淡水三肠目涡虫资源及分类学研究》；

5.主持国家自然科学基金面上项目《我国青藏高原淡水三肠目涡虫分类区系研究》；

6.主持河南省重大公益项目《黄河中下游生物多样性保育和生态廊道建设技术集成与示范》；

7.参与国家自然科学基金面上项目《海南岛淡水三肠目涡虫生态学及进化生物学研究》；

8.参与国家自然科学基金面上项目《组织再生关键基因的筛选及功能研究》；

9.参与国家自然科学基金面上项目《广东、广西淡水涡虫分类区系及系统进化研究》；

10.主持教育部教学改革项目《教师队伍建设体制机制研究》；

11.主持河南省重点教学改革项目《地方综合性本科师范院校创新型“人才培养模式与课程体系”的构建》，并获国家教学成果二等奖；

12.主持河南省重点教学改革项目《教师教育师资队伍建设机制改革》，获河南省教学成果一等奖；

13.参与河南省重点教学改革项目《人体寄生虫学教学内容、教学方法和教学手段改革与实践》获河南省教学成果一等奖。

学术成果：

代表性论文

  1. Wang L,Wang Y, Dong Z*, Chen G*, Sluy R, and Liu D. Integrative taxonomy a new speciesof Dugesia (Platyhelminthes, Tricladida, Dugesiidae) from unveils the southern portion of the Taihang Mountains in northern China, with the description of itscomplete mitogenome and an exploratory analysis of mitochondrial gene order asa taxonomic character. Integrative Zoology, 2021,0:1-22.

  2. Zimei Dong, Jinrui Huo, Ang Liang, Jinzi Chen, Guangwen Chen⁎, Dezeng Liu. Gamma-Secretase Inhibitor (DAPT), a potentialtherapeutic target drug,caused neurotoxicity in planarian regeneration by inhibiting Notch signaling pathway. Scienceof the Total Environment, 2021,781,146735.

  3. Lei Wang, Zi-mei Dong, Guang-wen Chen ⁎, Ronald Sluys, De-zeng Liu.Integrative descriptions of two new species of Dugesiafrom Hainan Island, China (Platyhelminthes, Tricladida, Dugesiidae). ZooKeys, 2021,1028:1–28.

  4. WangL, Chen J, Dong Z*, Chen G*, Sluy R, and Liu D. Two new species of Dugesia(Platyhelminthes, Tricladida, Dugesiidae) from the tropical monsoon forest insouthern China. ZooKeys , 2021,1059: 89-116.

  5. YiboYang, Peizheng Wang, Baijie Jin, Zimei Dong, Guangwen Chen ⁎,Dezeng Liu. Screening of Potential Key Transcripts Involved in PlanarianRegeneration and Analysis of Its Regeneration Patterns by PacBio Long-Read Sequencing.Front Genet, 2020,11: 580.

  6. Xueqiang Guo,Lingling Xi, Lifei Li, Jianlin Guo, Wei Jin, Cuifang Chang, Jingbo Zhang,Cunshuan Xu, Guangwen Chen*，circRNA-14723 promotes hepatocytes proliferation in rat liver regeneration by sponging rno-miR-16-5p.Journal Celluar Physiology,2020,29473.

  7. Zimei Dong, Fangfang Cheng, Yibo Yang, Fenxi Zhang, Guangwen Chen⁎, Dezeng Liu. Expression and functional analysis of flotillins in Dugesia japonica. Experimental Cell Research, 2019, 374:76-84.

  8. Fenxi Zhang, Zimei Dong,Shuai Gao, Guangwen Chen⁎, and Dezeng Liu. AT1R-Mediated Apoptosis of Bone Marrow Mesenchymal Stem Cells Is Associated with mtROS Production and mtDNA Reduction. Oxidative Medicine and Cellular Longevity, 2019, 4608165:1-9.

  9. Jing Kang, Zimei Dong, QinHao, Jing Wang, Guangwen Chena⁎, Dezeng Liu.The regulation of rapamycin in planarian Dugesia japonica Ichikawa & Kawakatsu, 1964 regeneration according to TOR signaling pathway. Ecotoxicology and Environmental Safety, 2019, 185:1-8

  10. Zhang HC, Ma KX, Yang YJ, Shi CY, Chen GW⁎, Liu DZ. CuZnSOD and MnSOD from freshwater planarian Dugesia japonica: cDNA cloning, mRNA expression and enzyme activity in response to environmental pollutants. Aquat Toxicol, 2019, 208:12-19.

  11. Ke-Xue Ma, Ge-ge Song, MengWu, He-Cai Zhang, Guang-Wen Chen⁎, De-Zeng Liu.Identificationof a potential tissue-specific biomarker cathepsin L-like gene from the planarian Dugesia japonica: Molecular cloning, characterization, and expressionin response to heavy metal exposure. Ecotoxicology and Environmental Safety,2019,180: 73-79.

  12. Kexue Ma, Yumei Zhang, Gege Song, Meng Wu and Guangwen Chen⁎.Identification of Autophagy-Related Gene 7 and Autophagic Cell Death in the Planarian Dugesia japonica.FRONTIERS IN PHYSIOLOGY,2018,9:1-10.

  13. Zhang HC, Ma KX, Yang YJ,Shi CY, Chen GW⁎, Liu DZ. Molecular cloning, characterization, expression and enzyme activityof Catalase from planrian Dugesia japonica in response to environmental pollutants. Ecotoxicology and Environmental Safety, 2018,165: 88-95.

  14. BaijieJin, Jing Ren, Jinzi Chen, Zimei Dong*, Guangwen Chen*, Dezeng Liu.Autophagy‑related DjAtg1‑1 plays critical role in planarian regeneration by regulating proliferation and cell death. Cell and Tissue Research, 2022, doi.org/10.1007/s00441-022-03591-3.

  15. Qinghua Wang, Lijuan Xie, Yixuan Wang, Baijie Jin, Jing Ren, Zimei Dong *,Guangwen Chen *, Dezeng Liu. Djhsp70s, especially Djhsp70c, play a key role in planarian regeneration and tissue homeostasis by regulating cell proliferation and apoptosis. Gene, 2022, 820 : 146215.

  16. Yingyu Liu, Jinzi Chen, Zimei Dong ⁎, Guangwen Chen ⁎, Dezeng Liu. Antioxidant responses and lipidperoxidation can be used as sensitive indicators for the heavy metals risk assessment of the Wei River: a case study of planarian Dugesia Japonica.Biomarkers, 2021:26: 55-64.

  17. Qinghua Wang, Yingyu Liu, Baijie Jin, Zimei Dong*, Guangwen Chen*, Dezeng Liu. Djmek is involved inplanarian regeneration by regulation of cell proliferation and apoptosis.Biochemical and Biophysical Research Communications,2020, 532:355-361.

  18. He-Cai Zhang, Yu-Juan Yang, Ke-Xue Ma, Chang-Ying Shi, Guang-Wen Chen ⁎, De-Zeng Liu.A novel sigma classglutathione S-transferase gene in freshwater planarian Dugesia japonica:cloning, characterization and protective effects in herbicide glyphosate stress.Ecotoxicology, 2020, 29:295–304.

  19. He‑Cai Zhang, Chang‑Ying Shi, Yu‑Juan Yang, Guang‑Wen Chen⁎, De‑ZengLiu. Biomarkers of Planarian Dugesia japonica in Response to Herbicide Glyphosate Exposure. Bulletin of Environmental Contamination and Toxicology,2020, 104:804–808.

  20. Zimei Dong, Gengbo Chu, Yingxu Sima, Guangwen Chen*. Djhsp90s are crucial regulators during planarianre generation and tissue homeostasis.Biochemical and Biophysical Research Communications, 2018, 498:723-728.

  21. Zimei Dong, Yibo Yang, Guangwen Chen⁎, Dezeng Liu. Identification of runt family genes involved in planarian regeneration and tissue homeostasis. Gene Expression Patterns,2018,29:24-31.

  22. Zimei Dong, Changying Shi, Gengbo Chu, Yanping Dong, Guangwen Chen⁎, Dezeng Liu. Morphological changes of gonad and gene expression patterns during desexualization in Dugesia japonica (Platyhelminthes:Dugesiidae). Zoologia (Curitiba),2018, 35:1-7.

  23. HeCai Zhang, ChangYing Shi, HuiHui Yang, GuangWen Chen⁎ , DeZeng Liu. Genotoxicity evaluation of ionic liquid 1-octyl-3-methylimidazolium bromide in freshwater planarian Dugesia japonica using RAPD assay. Ecotoxicology and Environmental Safety, 2016,134:17-22.

  24. Zimei Dong, Yanqing Yuwen, Qinghua Wang,Guangwen Chen⁎, Dezeng Liu. The characteristics of sox gene in Dugesia japonica. Mol Biol Rep,2011,38:3977-82.

  25. Zimei Dong, Yanqing Yuwen, Qinghua Wang, Guangwen Chen⁎, Dezeng Liu. Eight genes expression patterns during visual systemre generation in Dugesia japonica. Gene Expression Patterns, 2012,12:1-6.

  26. Zimei Dong, Changying Shi, Haixia Zhang, HeDou, Fangfang Cheng, Guangwen Chen⁎, Dezeng Liu. The characteristics of sox gene in Dugesia japonica. Gene, 2014,544:177-183.

  27. Fangfang Cheng, Zimei Dong, Yanping Dong, Yingxu Sima, Jing Chen, Xiaoyan Li, Guangwen Chen⁎, Dezeng Liu.Identification and expression analysis of a heat shock protein 70 gene in Polycelis sp. Cell Stress and Chaperones, 2015, 20:907-915.

  28. Zimei Dong, Fangfang Cheng, Yanqing Yuwen, Jing Chen, Xiaoyan Li, He Dou, Haixia Zhang, Guangwen Chen⁎, Dezeng Liu. Identification and expression analysis of a Spsb gene in planarian Dugesia japonica. Gene,2015,564:168-175.

  29. ZimeiDong, Tong Yang, Yibo Yang, He Dou, Guangwen Chen⁎. DjhnRNPA2/B1-like gene isrequired for planarian regeneration and tissue homeostasis. Gene,2017,633:9-16.

  30. Zimei Dong, Yanqing Yuwen, Yingxu Sima, Yanping Dong, Huina Zhan, Guangwen Chen⁎, Dezeng Liu. Photokinesis and Djopsin gene expression analysis during the regeneration of planarian eyes. Integrative Zoology, 2017,12:57-164.

  31. ZiMei Dong, GuangWen Chen⁎, HeCai Zhang, DeZeng Liu. A new species of Polycelis(Platyhelminthes, Tricladida,Planariidae) from China. Acta Zoologica Academiae Scientiarum Hungaricae, 2017,63:263-276.

  32. Yanqing Yuwen, Zimei Dong, Qinghua Wang, Xiaojuan Sun, Changying Shi, Guangwen Chen⁎. Evaluation of endogenous reference genes for analysis of gene expression with real-time RT-PCR duringplanarian regeneration. Mol Biol Rep,2011,38:4423–4428.

  33. Yanqing Yuwen, Zimei Dong, Xiaohui Si, Guangwen Chen⁎. A pumilio homolog in Polycelis sp.  Dev Genes Evol, 2014,224:53–56.

  34. HeCai Zhang, ChangYing Shi, LiQun Sun, FanWang, GuangWen Chen⁎.Toxic effects of ionic liquid1-octyl-3-methylimidazolium bromide on the antioxidant defense system offreshwater planarian, Dugesia japonica.Toxicology and Industrial Health, 2016, 32:1675–1683.

  35. HeCai Zhang, ChangYing Shi, Fan Wang,GuangWen Chen⁎, DeZeng Liu. Imidazolium-based ionic liquids: Effects of different alkyl-chain lengths on planarian Dugesia Japonica based on ingestion, regeneration and antioxidant response. Fresenius Environmental Bulletin,2016,25:3205-3212.

  36. HeCai Zhang, TongYi Liu, ChangYing Shi, GuangWen Chen⁎, DeZeng Liu. Genotoxicity evaluation of an urban river on freshwater planarian by RAPD assay. Bull Environ Contam Toxicol, 2017,98:484–488.

  37. Changying Shi, Zimei Dong, Hecai Zhang, Fangfang Cheng, Guangwen Chen⁎, Dezeng Liu. Cloning and characterization of DjPRPS gene in freshwater planarian Dugesia japonica. Turkish Journal of Biochemistry, 2015,40:58–65.

  38. ChangYing Shi, HeCai Zhang, GuangWen Chen⁎, LiQun Sun, DeZeng Liu. Toxicity of ionic liquid 1-octyl-3-methylimidazolium bromide on freshwater planarian, Dugesia Japonica. Fresenius Environmental Bulletin, 2013, 22:1609 -1615.

  39. Hecai Zhang, Guangwen Chen⁎, Xiaojuan Sun, CunshuanXu. Study on phylogenetic relationship of freshwater planarians (Turbellaria:Tricladida: Paludicola) in nine Chinese localities using RAPD method. Life Science Journal,2009,16:71-75.

  40. KeXue Ma, GuangWen Chen⁎, DeZeng Liu. cDNA cloningof heat shock protein 90 gene and protein expression pattern in response toheavy metal exposure and thermal stress in planarian Dugesia japonica. Mol Biol Rep, 2012,39:7203–7210.

  41. GuangWen Chen⁎, KeXue Ma DeZeng Liu.Changes of alkaline phosphatase activity in response to different stressors inplanarian Dugesia japonica. Biologia,2013,68:264-268.

  42. KeXue Ma, GuangWen Chen⁎, Hao Lou, LiNa Fei.Cloning and expression analysis of hsp70 gene from freshwater planarian Dugesia japonica. Biologia,2009,64:1018-1024.

  43. KeXue Ma, GuangWen Chen⁎, ChangYing Shi, FangFang Cheng, He Dou, ChengCheng Feng, DeZeng Liu. Molecular characterization of theglucose-regulated protein 78 (GRP78)gene in planarian Dugesia japonica. Comparative Biochemistry and Physiology, Part B,2014,171:12-17.

  44. Kexue Ma, Hecai Zhang, Yumei Zhang, Gege Song, Meng Wu, Guangwen Chen⁎ Identification of a HSP40 gene involved inplanarian regeneration. Biologia,2017,72（11）: 1-8.

  45. Xiaofang Geng, Gaiping Wang, Yanli Qin,Xiayan Zang, Pengfei Li, Zhi Geng, Deming Xue, Zimei Dong, Kexue Ma, GuangwenChen⁎,Cunshuan Xu⁎. iTRAQ-based quantitative proteomic analysis of the initiation of head regeneration in planarians. PLOS ONE, 2015. 10: e0132045.

  46. Guangwen Chen⁎, Yingli Wang, Huike Wang,Ruimin Fu, Jianfeng Zhang, Dezeng Liu. Chromosome and karyotype analysis of Polycelis wutaishanica (Turbellaria, Tricladida) from Shanxi Province, China.Acta Zootaxonomica Sinica, 2008, 33(3): 449-452.

  47. Guangwen Chen⁎, Ming-Zhen Zhang, Li-Feng Zhao, Cun-Shuan Xu. Expression patterns and action analysis of the genesass ociated with physiological responses during rat liver regeneration: Innateimmune response.World Journal of Gastroenterology, 2006,12(48): 7852-7858.


专利成果：

宁黔冀，杨洪，程鸿轩，陈广文. 保幼激素拮抗物溶液及用其提高水产养殖甲壳动物成活率方法.2008年获国家发明专利（专利号ZL200510017350.X）.


专著教材：

  1. 汪松，解焱，刘瑞玉，宋大祥，赵尔宓，李振宇，伍汉霖，武云飞，何芬奇，丁长青，周江，陈又生，刘月英，吴岷，袁德成，武春生，杨亲二，耿玉英，费梁，刘惠宁，杨思凉，Ohler Annemarie, William Bleisch, 陈辈乐，陈广文（负责淡水涡虫部分）等112位专家,《中国物种红色名录--第一卷：红色名录》,北京,高等教育出版社，2004年8月.

  2. 汪松，解焱，刘瑞玉，宋大祥，刘月英，吴岷，袁德成，武春生，杨思凉，陈广文（负责淡水涡虫部分）等30位专家,《中国物种红色名录--第三卷：无脊椎动物》,北京,高等教育出版社，2005年7月.

  3. 陈广文（负责淡水涡虫部分）等. 《中国大百科全书》（第二版），2：365, 北京,中国大百科全书出版社，2009年3月.

  4. 陈广文（负责淡水涡虫部分）等, 《中国大百科全书》（第二版），18：474. 北京,中国大百科全书出版社，2009年3月.

  5. 陈广文（负责淡水涡虫部分）等, 《中国大百科全书》（第二版），29： 286, 北京,中国大百科全书出版社，2009年3月.

  6. 陈广文，李仲辉主编,《动物学实验技术》,北京,科学出版社，2008年2月.


奖励：

  1. 陈广文（1/7），地方综合性本科师范院校创新型“人才培养模式与课程体系”的构建与实践.国家教学成果二等奖，2014。

  2. 陈广文（1/6），基础教育生物学拔尖人才培养模式研究与实践。国家教学成果二等奖，2018。

  3. 陈广文（7/9），大鼠肝再生的功能基因组学研究，国家教育部.高等学校科学研究优秀成果奖（自然科学奖）二等奖，2010。

  4. 陈广文（4/5），微量蛋白电泳及超敏感染色技术，河南省科技进步三等奖，1995。







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