叶丙雨

2010年09月～2016年05月：在军事医学研究院生物工程研究所完成硕博课题；

2016年06月：获首都师范大学遗传学博士学位；

2016年12月～2018年11月：betway官方app 生物学流动站在站博士后；

2018年12月～至今：betway官方app 生命科学学院讲师、硕士生导师。

主持河南省重点研发与推广专项（科技攻关）、河南省高等学校重点科研项目计划、河南省博士后启动基金及betway官方app 博士科研启动基金等；参与国家自然科学基金和“973”等国家级项目。主讲本科生《分子生物学》、《食品化学》等专业必修课程。指导本科生参加全国大学生生命科学竞赛暨河南省大学生生命科学竞赛，获国家二/三等奖、河南省一/二等奖，并获“优秀指导教师”称号。目前指导2名在读硕士研究生。在FASEB J，BMC GENOMICS，iScience，Front. Genet.，Biochem. Biophys. Res. Commun.，PeerJ，Mol. Biol.等SCI期刊和中文核心期刊发表科研论文30余篇。

表观遗传学，研究方向为三维基因组的结构与功能。

研究内容：（1）细胞周期表观遗传信息传递；（2）利用再生模型和肝病模型，通过多组学的整合分析解析肝再生及肝纤维化等表观调控机制，寻找肝病的生物标志物及靶点药物。研究技术/方法包括但不限于Chromatin Conformation Capture（Hi-C）、(sc)ATAC-seq、ChIP-seq、(sc)CUT&Tag(Run)、HiCuT、Hi-TrAC、(sc)RNA-seq等。

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1. 河南省重点研发与推广专项（科技攻关），222102310589，2022-01至2023-12，在研，主持

2. 河南省高等学校重点科研项目计划，21A180009，2021-01至2022-12，已结题，主持

3. betway官方app 博士科研启动基金，2020-01至2022-12，已结题，主持

4. 河南省博士后科研项目启动经费，001803040，2018-01至2018-12，已结题，主持

5. 国家自然科学基金委员会，面上项目，31370762，2014-01至2017-12，已结题，参加

6. 国家自然科学基金委员会，面上项目，81372218，2014-01至2017-12，已结题，参加

7. 国家重点基础研究发展规划，973项目，2013CB966802，2013-01至2017-08，已结题，参加

#: co-first author, *: co-corresponding author

2023

1. Bingyu Ye#, Wenlong Shen#, YanchangLi#, Dong Wang, Yan Zhang, Ping Li, Man Yin, Yahao Wang, Dejian Xie,Shu Shi, Tao Yao, Juncai Chen, Ping Xu*, Zhihu Zhao*. FAIRE-MS reveals mitotic retention of transcriptional regulators on a proteome-wide scale. The FASEB Journal, 2023, 37(2): e22724.

1. Bingyu Ye#, Wenlong Shen#, Chunyan Zhang#, Mengli Yu, Xinru Ding, Man Yin, Yahao Wang, Xinjie Guo, Ge Bai,Kailin Lin, Shu Shi, Ping Li, Yan Zhang, Guoying Yu*, Zhihu Zhao*. The role of ZNF143 overexpression in rat liver cell proliferation. BMC Genomics, 2022, 23: 483.

2. Wenlong Shen#, Yan Zhang#*, Minglei Shi#,Bingyu Ye, Man Yin, Ping Li, Yifei Jin, Zhang Zhang, Shu Shi, Michael Zhang, Yang Chen*, Zhihu Zhao*. Profiling and characterization of constitutive chromatin enriched RNAs. iScience, 2022,25: 105349.

3. Chunyan Zhang, Caifang Sun, Yabin Zhao, Qiwen Wang, Jianlin Quo, Bingyu Ye*, GuoYing Yu*. Overview of microRNAs as diagnostic and prognostic biomarkers for high-incidence cancers in 2021. International Journal of Molecular Sciences, 2022, 23(19): 11389.

4. Chunyan Zhang, Yabin Zhao, Mengli Yu, Jianru Qin, Bingyu Ye*,Qiwen Wang*. Mitochondrial dysfunction and chronic liver disease. Current Issues in Molecular Biology, 2022,44: 3156-3165.

5. Yahao Wang#, Wenlong Shen#*, Man Yin, Wenhua Huang, Bingyu Ye, Ping Li, Shu Shi, Ge Bai, Xinjie Guo, Yifei Jin,Kailin Lin, Yan Zhang, Yongqiang Jiang*, Junfeng Wang*, Yanping Han*, Zhihu Zhao*. Changes in higher-Order chromosomal structure of Klebsiella pneumoniae under simulated microgravity. Frontiers in Microbiology, 2022, 13: 879321.

6.Chunyan Zhang,Yabin Zhao, Qiwen Wang, Jianru Qin, Bingyu Ye, Cunshuan Xu*,GuoYing Yu*. Overexpression of miR-125a-5p inhibits hepatocyte proliferation through the STAT3 regulation in vivo and in vitro. International Journal of Molecular Sciences, 2022, 23:8661.

2020

1. Man Yin#, Bingyu Ye#, Yifei Jin,Lin Liu, Yan Zhang, Ping Li, Yahao Wang, Ye Li, Yanping Han, Wenlong Shen*,Zhihu Zhao*. Changes in growth of Vibrio natriegens under simulated microgravity. Frontiers in Microbiology, 2020, 11: 2040.

2. Bingyu Ye#, Wenlong Shen#, ZhihuZhao*. ZNF143 is dynamically bound to a subset of its interphase sites duringmitosis. Biochemical and Biophysical Research Communications, 2020, 523(2): 293-298.

3. Bingyu Ye#, Ganggang Yang#, YuanmengLi, Chunyan Zhang*, Qiwen Wang*, Guoying Yu*. ZNF143 in chromatin looping and generegulation. Frontiers in Genetics, 2020,11: 338.

2019

1. Bingyu Ye#, Li Yin#, Qiwen Wang,Cunshuan Xu*. ACC1 is overexpressed in liver cancers and contributes to the proliferation of human hepatoma Hep G2 cells and the rat liver cell line BRL 3A. Molecular Medicine Reports, 2019, 19(5):3431-3440.

2. Qiwen Wang#, Bingyu Ye#, Ping Wang,Fenjie Yao, Chunyan Zhang*, Guoying Yu*. Overview of microRNA-199a regulationin cancer. Cancer Management and Research, 2019, 11:10327-12335.

3. Chunyan Zhang#, Bingyu Ye#, Jiaojiao Wei, Qiwen Wang*, Cunshuan Xu*, Guoying Yu*. MiR-199a-5p regulates rat liver regeneration and hepatocyte proliferation by targeting TNF-α TNFR1/TRADD/CASPASE8/CASPASE3 signalling pathway. Artificial Cells Nanomedicine and Biotechnology,2019, 47(1):4110-4118.

2018

1. Bingyu Ye, Wenlong Shen, Minglei Shi, Yan Zhang,Cunshuan Xu*, Zhihu Zhao*. Intein-mediated backbone cyclization of entolimod confers enhanced radioprotective activity in mouse models. PeerJ, 2018, 6: e5043.

2017

1. Qi Xie, Fengxu Fan, Wei Wei, Yang Liu, Zhongwei Xu, Linhui Zhai, Yingzi Qi, Bingyu Ye, Yao Zhang, Sumit Basu, Zhihu Zhao, Junzhu Wu*, Ping Xu*. Multi-omics analyses reveal metabolic alterations regulated by hepatitis B virus core protein in hepatocellular carcinoma cells. Scientific Reports,2017, 7: 41089.

2016

1. Bingyu Ye, Wenlong Shen, Dong Wang, Ping Li, Zhang Zhang,Minglei Shi, Yan Zhang, Feixiong Zhang*, Zhihu Zhao*. ZNF143 is involved in CTCF-mediated chromatin interactions by cooperation with cohesin and other partners. MolecularBiology, 2016, 50(3): 431-437.

2. Zhang Zhang, Yan Zhang, Minglei Shi, Bingyu Ye, Wenlong Shen, Ping Li, Lingyue Xing, Xiaopeng Zhang, Lihua Hou, Junjie Xu, Zhihu Zhao*,Wei Chen*. Anthrax susceptibility: human genetic polymorphisms modulating ANTXR2 expression. Toxins, 2016,8(1): 1.

2015

1. Wenlong Shen, Dong Wang, Bingyu Ye, Yan Zhang*, Zhihu Zhao*.GC3-biased gene domains in mammalian genomes. Bioinformatics, 2015, 31(19): 3081-3084.

2. Wenlong Shen, Dong Wang,Bingyu Ye, Yan Zhang*, Zhihu Zhao*. A possible role of Drosophila CTCF in mitotic bookmarking and maintaining chromatin domains during the cell cycle.Biological Research, 2015,48(1): 27.