代表性论文: 1. Ye X, Yu, WuY, Han J, Li S, Wu Q, Li D, Qi J*,An efficient large-scale refolding technique for recovering biologicallyactive recombinant human FGF-21 from inclusion bodies. International Journal ofBiological Macromolecules. 2019, 135:362-372. 2. Qi J, Ye X, Li L, Bai H, Xu C*.Improving the specific antitumor efficacy ofONC by fusion with N-terminal domain of transferring. Bioscience,Biotechnology, and Biochemistry. 2018, 82(7):1153-1158. 3. Ye X, Qi J, Wu Y, Yu D, Xu P, Li S, Zhu S, WuQ, Ren G, Li D*. Comparison of PEGylated FGF-21 with insulin glargine for long-lasting hypoglycaemiceffect in db/db mice. Diabetes Metab, 2015, 41(1):82-90. 4. Ye X, Qi J, Yu D, Wu Y, Zhu S, Li S, Wu Q,Ren G, Li D*. Pharmacological efficacy of FGF21 analogue, liraglutide andinsulin glargine in treatment of type 2 diabetes. J Diabetes Complications.2017, 31(4): 726-34. 5. Ye X, Qi J, Yu D, Li S, Wu Q, Wu Y, Ren G,Han J, Li D*. Pilot-scale production and characterization of PEGylated humanFGF-21 analog. J Biotechnol. 2016, 228: 8-17. 6. Ye X, Qi J, Wu Q, Yu D, Li S, Wu Y, Li D*.Long-lasting hypoglycemic effect of modified FGF-21 analog with polyethyleneglycol in type 1 diabetic mice and its systematic toxicity. Eur J Pharmacol. 2016,781: 198-208. 7. Ye X, Qi J, Ren G, Xu P, Wu Y, Zhu S, Yu D,Li S, Wu Q, Muhi RL, Li D*. Long-lasting anti-diabetic efficacy of PEGylatedFGF-21 and liraglutide in treatment of type 2 diabetic mice. Endocrine, 2015, 49(3):683-92.专利成果: 1. 一种治疗代谢疾病的重组人成纤维细胞生长因子21融合蛋白及其制备方法和应用.授权,第二发明人。 2. 一种治疗代谢疾病的重组人成纤维细胞生长因子21融合蛋白及其制备方法和应用。授权,第二发明人。 3. 一种靶向治疗肿瘤的重组融合蛋白及其制备方法和应用。受理,第一发明人。 4. 豹蛙抗瘤酶融合蛋白作为治疗肿瘤药物的应用。受理,第一发明人。
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