个人简介：马春华，男，博士，讲师，中国化学会会员。E-mail:2016007@htu.edu.cn
教育经历：
2004.09-2008.06山东大学药学院，药学专业，理学学士；
2008.09-2013.12山东大学药学院，药物化学专业，理学博士；
工作经历：
2013.12-2015.12，复旦大学药学院，药物化学专业，博士后；
2016.03-至今，betway官方app 化学化工学院讲师。
研究领域与兴趣：
1、小分子抗肿瘤药物的设计合成
2、基于靶点的先导化合物的设计和结构优化
1、国家自然科学基金青年基金：基于腺嘌呤替代物的双底物SAHH抑制剂的设计、合成及活性研究，项目批准号：82003585, 2021.01-2023. 12,24.00万元
2、河南省自然科学基金：小分子神经生长因子模拟物的设计、合成及作用机制研究，项目编号：162300410182, 2017.1-2018.12, 10万元
3、河南省高等学校重点科研项目基础研究计划：小分子NGF模拟物的设计、合成及应用研究，项目编号：17A350008, 2017.1-2018.12，3万元
4、高端外国专家项目：I类新药布鲁顿酪氨酸激酶抑制剂（BTK inhibitor HB040）的研究与开发，项目编号：GDW20186300346, 30万元
5、企业横向：新型BTK抑制剂的研究与开发，合同编号：XH2019059，50万元
代表性论文：
12)Chunhua Ma*,Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu,* Yuqin Jiang,* and Qingjie Ding*.Discovery of1-Amino-1H-imidazole-5-carboxamideDerivatives as Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitors.Journal of Medicinal Chemistry,2021,https://doi.org/10.1021/acs.jmedchem.1c01559.
11）Chunhua Ma, Yu Ji, Jie Zhao, Xing He, Shuting Zhang,*Yuqin Jiang,*and Bing Yu*. Transition-metal-free three-component acetalation-pyridylation of alkenes via photoredox catalysis.Chinese Journal of Catalysis,2021,DOI: 10.1016/S1872-2067(21)63917-7
10）Dandan Zhang#, Guiqing Xu#, Jie Zhao#, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang,Chunhua Ma*, Yuqin Jiang*, Qingjie Ding*. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase.European Journal of Medicinal Chemistry,2021,225, 113724.
9）Chunhua Ma,Zhiwen Feng, Jing Li,Dandan Zhang, Wei Li,Yuqin Jiang*and Bing Yu*. Photocatalytic Transition-Metal-Free Direct3-Alkylationof 2-Aryl-2H-Indazoles in Dimethyl Carbonate,Organic Chemistry Frontiers,2021, 8, 3286-3291.
8）Yuqin Jiang,Jing Li, Zhiwen Feng, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li,Chunhua Ma*and Bing Yu*. Ethylene glycol: a green solvent for visible light-promoted aerobic transition metal-free cascade sulfonation/cyclization reaction,Advanced Synthesis & Catalysis,2020, 362(13), 2609-2614.
7）Zhiwen Feng, Jing Li, Yuqin Jiang, Yu Tian, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li,Chunhua Ma*and Bing Yu*, Transition-metal-free sulfonylations of methylthiolated alkynones to synthesize 3-sulfonylated thioflavones,New Journal of Chemistry, 2020, 44, 14786-14790.
6)Jiaxuan Shen,*Nannan Li, Yanjiang Yu, andChunhua Ma*.Visible-Light-Induced Oxidation/[3 + 2] Cycloaddition/Oxidative Aromatization to Construct Benzo[a]carbazoles from 1,2,3,4-Tetrahydronaphthalene and Arylhydrazine Hydrochlorides,Organic Letter2019, 21(17), 7179-7183.
5)Ma, C.; Miao, Y.; Zhao, M.; Wu, P.; Zhou, J.; Li, Z.; Xie, X.; Zhang, W.*, Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydrantoin (DBH).Tetrahedron2018, 74 (27), 3602-3607.
4)Ma, C.; Fan, G.; Wu, P.; Li, Z.; Zhou, Y.; Ding, Q.; Zhang, W.*, 1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water.Organic & Biomolecular Chemistry2017, 15 (46), 9889-9894.
3)Ma, C.; Cao, J.; Liang, X.; Huang Y.; Wu, P; Li, Y.; Xu, W.; Zhang, Y.*; Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, Synthesis and activity evaluation.European Journal of Medicinal Chemistry2016, 108, 21-27.
2)Ma, C.; Li, X.; liang, X.; Jin, K.; Cao, J.; Xu, W.*, Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN).Bioorganic & Medicinal Chemistry Letters2013, 23 (17), 4948-4952.
1)Ma, C.; Jin, K.; Cao, J.; Zhang, L.; Li, X.; Xu, W.*, Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN).Bioorganic & Medicinal Chemistry2013, 21 (7), 1621-1627.
获得荣誉与奖励：
betway官方app 优秀教师
Individual profile：Chunhua Ma，Male，Ph D，lecturer，Membership of China Chemical Society.E-mail:2016007@htu.edu.cn
Education experience：
2004.09-2008.06 School of pharmaceutical sciences Shandong University, Pharmacology, Bachelor of Science;
2008.09-2013.12 School of pharmaceutical sciences Shandong University,Medicinal chemistry, Doctor of Medicine.
Work experience：
2013.12-2015.12, School of Pharmacy Fudan University, Medicinal chemistry, Post doctor;
2016.03-until now, School of Chemistry and Chemical Engineering, Henan Normal University, Lecturer.
Research Interest：
1、The design and synthesis of small molecular compounds with antitumor activity
2、Target-based design and structure optimization of lead compounds
近年来主持的主要科研项目:
1、Henan Natural Science Foundation：The design, synthesis and mechanism of small molecular never growth factor mimics, Project number：162300410182, 2017.1-2018.12, 0.1Million
2、Basic Research Plan of Key Scientific Research Projects in Henan Higher Education Institutions：The design, synthesis and application of small molecular never growth factor mimics, Project number：17A350008, 2017.1-2018.12，0.03 Million
3、High-end Foreign Expert Project：Research and Development of Bruton Tyrosine Kinase Inhibitor (BTK inhibitor HB040), Project number：GDW20186300346，3 Million
代表性论文：
12)Chunhua Ma*,Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu,* Yuqin Jiang,* and Qingjie Ding*.Discovery of1-Amino-1H-imidazole-5-carboxamideDerivatives as Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitors.Journal of Medicinal Chemistry,2021,https://doi.org/10.1021/acs.jmedchem.1c01559.
11）Chunhua Ma, Yu Ji, Jie Zhao, Xing He, Shuting Zhang,*Yuqin Jiang,*and Bing Yu*. Transition-metal-free three-component acetalation-pyridylation of alkenes via photoredox catalysis.Chinese Journal of Catalysis,2021,DOI: 10.1016/S1872-2067(21)63917-7
10）Dandan Zhang#, Guiqing Xu#, Jie Zhao#, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang,Chunhua Ma*, Yuqin Jiang*, Qingjie Ding*. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase.European Journal of Medicinal Chemistry,2021,225, 113724.
9）Chunhua Ma,Zhiwen Feng, Jing Li,Dandan Zhang, Wei Li,Yuqin Jiang*and Bing Yu*. Photocatalytic Transition-Metal-Free Direct3-Alkylationof 2-Aryl-2H-Indazoles in Dimethyl Carbonate,Organic Chemistry Frontiers,2021, DOI: 10.1039/D1QO00064K.
8）Yuqin Jiang,Jing Li, Zhiwen Feng, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li,Chunhua Ma*and Bing Yu*. Ethylene glycol: a green solvent for visible light-promoted aerobic transition metal-free cascade sulfonation/cyclization reaction,Advanced Synthesis & Catalysis,2020, 362(13), 2609-2614.
7）Zhiwen Feng, Jing Li, Yuqin Jiang, Yu Tian, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li,Chunhua Ma*and Bing Yu*, Transition-metal-free sulfonylations of methylthiolated alkynones to synthesize 3-sulfonylated thioflavones,New Journal of Chemistry, 2020, 44, 14786-14790.
6)Jiaxuan Shen,*Nannan Li, Yanjiang Yu, andChunhua Ma*.Visible-Light-Induced Oxidation/[3 + 2] Cycloaddition/Oxidative Aromatization to Construct Benzo[a]carbazoles from 1,2,3,4-Tetrahydronaphthalene and Arylhydrazine Hydrochlorides,Organic Letter2019, 21(17), 7179-7183.
5)Ma, C.; Miao, Y.; Zhao, M.; Wu, P.; Zhou, J.; Li, Z.; Xie, X.; Zhang, W.*, Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydrantoin (DBH).Tetrahedron2018, 74 (27), 3602-3607.
4)Ma, C.; Fan, G.; Wu, P.; Li, Z.; Zhou, Y.; Ding, Q.; Zhang, W.*, 1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water.Organic & Biomolecular Chemistry2017, 15 (46), 9889-9894.
3)Ma, C.; Cao, J.; Liang, X.; Huang Y.; Wu, P; Li, Y.; Xu, W.; Zhang, Y.*; Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, Synthesis and activity evaluation.European Journal of Medicinal Chemistry2016, 108, 21-27.
2)Ma, C.; Li, X.; liang, X.; Jin, K.; Cao, J.; Xu, W.*, Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN).Bioorganic & Medicinal Chemistry Letters2013, 23 (17), 4948-4952.
1)Ma, C.; Jin, K.; Cao, J.; Zhang, L.; Li, X.; Xu, W.*, Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN).Bioorganic & Medicinal Chemistry2013, 21 (7), 1621-1627.
获得荣誉与奖励：
Excellent Teachers of Henan Normal University